Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| PARK2 | 5071 | parkin RBR E3 ubiquitin protein ligase | 6 | PDJ, AR-JP, parkin |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20696900 | 2010 | Cell line : HCT116, DLD1 Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 100 Stage : - | Array comparative genomic hybridization (aCGH),Real-Time RT- PCR,Lentiviral Transfections and in Vitro Proliferation Assays,Immunoblotting | Deletion Mutation | - | PARK2 is a tumor suppressor gene whose haploinsufficiency cooperates with mutant APC in colorectal carcinogenesis. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Parkinson disease |
| Description | The precise function of this gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support. [provided by RefSeq, Jul 2008] | Chromosome | 6 |
| Location | 6q25.2-q27 |
| Start | 161768590 |
| End | 163148834 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 1380245 |
| OMIM ID | 602544 |
| HGNC ID | HGNC:8607 |
| Unigene ID | Hs.132954 |
| Ensembl ID | ENSG00000185345 |
| PharmGKB ID | PA32942 |
mRNA Information
| mRNA ID | XM_011535863.1 |
|---|---|
| Exon | join(1..141,284330..284493,465038..465278,526554..526672, 673629..673712,754386..754501,941895..942031, 1158387..1158448,1178800..1178949,1340926..1341009, 1367598..1367715,1377592..1380386) | mRNA Sequence | Download Select all |
| Length | 4211 |
Protein Information
| Protein ID | XP_011534165.1 |
|---|---|
| Protein Name | parkin RBR E3 ubiquitin protein ligase |
| Molecular Wt. (Da) | 45190 |
| Protein Sequence | Download Select all |
| Length | 464 |
| Uniprot ID | P19544 |
| Ensembl Protein ID | ENSP00000368370 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 834 | CASP1 | 977 | NP_150634.1 | in vitro | 12692130 |
| 1739 | DLG1 | 3007 | NP_004078.2 | in vitro | 16637659 |
| 2904 | GRIN2B | 697 | NP_000825.2 | in vitro;in vivo | 11679592 |
| 5688 | PSMA7 | 5967 | NP_002783.1 | in vivo;yeast 2-hybrid | 15987638 |
| 5810 | RAD1 | 4400 | NP_596868.1 | yeast 2-hybrid | 16169070 |
| 5879 | RAC1 | 3627 | NP_061485.1 | yeast 2-hybrid | 16169070 |
| 5903 | RANBP2 | 3111 | NP_006258.3 | in vitro;in vivo | 16332688 |
| 5997 | RGS2 | 2917 | NP_002914.1 | yeast 2-hybrid | 16169070 |
| 5998 | RGS3 | 3720 | NP_652759.3 | in vitro | 16637659 |
| 6622 | SNCA | 1227 | NP_000336.1 | in vivo | 11588587 |
| 7314 | UBB | 6771 | NP_061828.1 | in vitro | 15105460 |
| 7326 | UBE2G1 | 3340 | NP_003333.1 | in vitro | 11439185 |
| 7965 | AIMP2 | 2915 | NP_006294.2 | in vitro;yeast 2-hybrid | 12783850 |
| 8573 | CASK | 2164 | NP_003679.2 | in vitro;in vivo | 11679592 |
| 9319 | TRIP13 | 5145 | NP_004228.1 | yeast 2-hybrid | 16189514 |
| 56901 | NDUFA4L2 | 14249 | NP_064527.1 | yeast 2-hybrid | 16169070 |
| 284004 | HEXDC | 8677 | NP_775891.2 | yeast 2-hybrid | 16169070 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Parkinson's disease | hsa05012 |
| Protein processing in endoplasmic reticulum | hsa04141 |
| Ubiquitin mediated proteolysis | hsa04120 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd01798 | Mar-72 | parkin_N |
| cl00155 | Mar-72 | UBQ superfamily |
| pfam00240 | 13-73 | ubiquitin |
| cd01769 | Apr-72 | UBL |
| cd00196 | Apr-72 | UBQ |
| cd01803 | Jan-72 | Ubiquitin |
| cd01806 | Jan-70 | Nedd8 |
| cd01809 | 15-72 | Scythe_N |
| cd01805 | Jan-73 | RAD23_N |
| smart00647 | 313-375 | IBR |
| cl19760 | 313-375 | IBR superfamily |
| pfam11976 | 15-70 | Rad60-SLD |
| PTZ00044 | 18-70 | PTZ00044 |
| cd01808 | 15-70 | hPLIC_N |
| cd01812 | Mar-71 | BAG1_N |
| cd01793 | Jan-72 | Fubi |
| pfam01485 | 332-375 | IBR |
| cd01807 | 15-73 | GDX_N |
| cd01796 | 13-71 | DDI1_N |
| pfam01485 | 412-453 | IBR |
| cl19760 | 412-453 | IBR superfamily |
| smart00213 | Jan-72 | UBQ |
| TIGR00601 | Feb-73 | rad23 |
Ontology Information
| HPRD ID | 2046 |
|---|---|
| Molecular Class | Ubiquitin proteasome system protein |
| Molecular Function | DNA repair protein (GO:0003685) |
| Biological Process | DNA repair (GO:0006281) |
Drug Information
No matching records could be found.