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General Information
- Evidence
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- Protein
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- Enzyme
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25907934 | 2015 | Cell line : - Source : King Khalid University Hospital, Riyadh, Saudi Arabia. Sample Type : CRC Blood No. of Sample : 50 Stage : - | MTT assay,Hoechst 33342 staining,Flow cytometry,RT-qPCR,Western blotting | Down-regulation | - | Down-regulated mRNA expressions of CCND1, CDK4, c-MYC, BCL2, CASPASE3, PARP1 and EIF4A, increased PDCD4 protein expression and reduced p-AKT protein expression. |
| 24870775 | 2014 | Cell line : - Source : University of So Francisco. Sample Type : CRC tumor No. of Sample : 98 Stage : TNM Stage I-IV | PCR,Sequencing | Polymorhpism | - | PARP-1 Lys933Asn and Lys945Asn alterations could be associated with increased risk of CRC in the Saudi population. |
| 25268610 | 2014 | Cell line : SW480 Source : - Sample Type : - No. of Sample : - Stage : - | Genotyping and Expression,Real-Time PCR,Single-nucleotide polymorphisms (SNPs),PCR-RFLP. | Polymorphism/Down-regulation | - | Colorectal cancer present expression changes in several BER genes, suggesting a role for APE1, XRCC1, PARP1 and OGG1 and APE1 polymorphism in colorectal carcinogenesis. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Poly (ADP-ribose) polymerases |
| Description | This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008] | Chromosome | 1 |
| Location | 1q41-q42 |
| Start | 226548392 |
| End | 226595801 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 47410 |
| OMIM ID | 173870 |
| HGNC ID | HGNC:270 |
| Unigene ID | Hs.177766 |
| Ensembl ID | ENSG00000143799 |
| PharmGKB ID | PA32 |
mRNA Information
| mRNA ID | NM_001618.3 |
|---|---|
| Exon | join(1..291,5722..5887,15787..15902,17477..17691, 19346..19445,21659..21775,22421..22597,24918..25065, 26893..27033,27937..28179,28460..28528,28827..28959, 30798..30993,33747..33875,37584..37667,39780..39902, 40493..40621,42049..42147,42947..43099,44031..44158, 44941..45002,46018..46132,46560..47410) | mRNA Sequence | Download Select all |
| Length | 4001 |
Protein Information
| Protein ID | NP_001609.2 |
|---|---|
| Protein Name | poly (ADP-ribose) polymerase 1 |
| Molecular Wt. (Da) | 112953 |
| Protein Sequence | Download Select all |
| Length | 1014 |
| Uniprot ID | P43355 |
| Ensembl Protein ID | ENSP00000349085 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| L | Proteolytic Cleavage | 525 |
| D | Proteolytic Cleavage | 536 |
| D | Proteolytic Cleavage | 214 |
| S | Phosphorylation | 179;- |
| S | Phosphorylation | 41 |
| T | Phosphorylation | 368 |
| S | Phosphorylation | 372 |
| S | Phosphorylation | 782 |
| K | Acetylation | 97 |
| K | Acetylation | 600 |
| K | Acetylation | 621 |
| K | Acetylation | 105 |
| K | Acetylation | 131 |
| K | Acetylation | 548 |
| S | Phosphorylation | 177 |
| S | Phosphorylation | 274 |
| S | Phosphorylation | 465 |
| S | Phosphorylation | 864 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 596 | BCL2 | 1045 | NP_000624.2 | in vitro;in vivo | 11790116 |
| 1026 | CDKN1A | 298 | NP_510867.1 | in vitro;in vivo | 12930846 |
| 1058 | CENPA | 313 | NP_001800.1 | in vivo | 12011073 |
| 1059 | CENPB | 314 | NP_001801.1 | in vivo | 12011073 |
| 1869 | E2F1 | 1806 | NP_005216.1 | in vitro;in vivo | 14627987 |
| 2547 | XRCC6 | 1071 | NP_001460.1 | in vivo | 17283121 |
| 3980 | LIG3 | 2966 | NP_039269.2 | in vitro;in vivo;yeast 2-hybrid | 12897160 |
| 4691 | NCL | 1245 | NP_005372.2 | in vitro | 9642267 |
| 4790 | NFKB1 | 1238 | NP_003989.2 | in vitro;in vivo | 11590148 |
| 4869 | NPM1 | 1246 | NP_002511.1 | in vitro | 9642267 |
| 5451 | POU2F1 | 1250 | NP_002688.2 | in vitro;yeast 2-hybrid | 9537509 |
| 5914 | RARA | 6769 | NP_000955.1 | in vivo | 15808511 |
| 5970 | RELA | 1241 | NP_068810.3 | in vitro;in vivo | 11590148 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Base excision repair | hsa03410 |
| NF-kappa B signaling pathway | hsa04064 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd01437 | 662-1006 | parp_like |
| cl00283 | 662-1006 | ADP_ribosyl superfamily |
| cd08001 | 543-645 | WGR_PARP1_like |
| cl01581 | 543-645 | WGR superfamily |
| cd00027 | 392-461 | BRCT |
| cl00038 | 392-461 | BRCT superfamily |
| pfam02877 | 665-795 | PARP_reg |
| cl03756 | 665-795 | PARP_reg superfamily |
| pfam00645 | Dec-90 | zf-PARP |
| cl02913 | Dec-90 | zf-PARP superfamily |
| cd07997 | 544-645 | WGR_PARP |
| cd07994 | 554-627 | WGR |
| pfam00645 | 116-200 | zf-PARP |
| cl02913 | 116-200 | zf-PARP superfamily |
| pfam08063 | 279-332 | PADR1 |
| cl06892 | 279-332 | PADR1 superfamily |
| smart00773 | 548-633 | WGR |
| cd01341 | 860-1001 | ADP_ribosyl |
| pfam05406 | 549-633 | WGR |
| cd08003 | 544-645 | WGR_PARP2_like |
| cd08002 | 552-645 | WGR_PARP3_like |
| pfam00533 | 388-461 | BRCT |
| cd01438 | 800-1003 | tankyrase_like |
| smart00292 | 388-461 | BRCT |
| cd01439 | 859-948 | TCCD_inducible_PARP_like |
| cd07996 | 576-622 | WGR_MMR_like |
| COG3831 | 576-621 | WGR |
| PLN03123 | 6-1010 | PLN03123 |
| PLN03124 | 436-1011 | PLN03124 |
| PLN03122 | 250-1010 | PLN03122 |
| pfam00644 | 797-1007 | PARP |
| COG0272 | 387-459 | Lig |
| TIGR00575 | 373-457 | dnlj |
Ontology Information
| HPRD ID | 2166 |
|---|---|
| Molecular Class | Enzyme: Ribosyltransferase |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Biological_process unknown (GO:0000004) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P09874 | DB02701 | Nicotinamide | SmallMoleculeDrug |
| P09874 | DB09074 | Olaparib | SmallMoleculeDrug |