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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| PATZ1 | 23598 | POZ (BTB) and AT hook containing zinc finger 1 | 22 | MAZR, dJ400N23, ZBTB19, ZSG, RIAZ, PATZ |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 0 | 0 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | - | Unknown | - | Telomerase activity and hPOT1 gene expression may serve as a promising tumor marker for colorectal cancer |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | -, "Zinc fingers, C2H2-type", "BTB/POZ domain containing" |
| Description | The protein encoded by this gene contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t(1;22)(p36.1;q12). The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are described for this gene. [provided by RefSeq, Jul 2008] | Chromosome | 22 |
| Location | 22q12.2 |
| Start | 31721790 |
| End | 31742249 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 20460 |
| OMIM ID | 605165 |
| HGNC ID | HGNC:13071 |
| Unigene ID | Hs.731398 |
| Ensembl ID | ENSG00000100105 |
| PharmGKB ID | PA162398806 |
Protein Information
| Protein ID | NP_055138.2 |
|---|---|
| Protein Name | POZ (BTB) and AT hook containing zinc finger 1 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 687 |
| Uniprot ID | Q9NXR8 |
| Ensembl Protein ID | ENSP00000320566 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 243 |
| S | Phosphorylation | 249 |
| S | Phosphorylation | 243 |
| S | Phosphorylation | 249 |
| S | Phosphorylation | 243 |
| S | Phosphorylation | 249 |
| S | Phosphorylation | 243 |
| S | Phosphorylation | 249 |
| S | Phosphorylation | 282 |
| S | Phosphorylation | 282 |
| S | Phosphorylation | 282 |
| S | Phosphorylation | 282 |
| S | Phosphorylation | 378 |
| S | Phosphorylation | 378 |
| S | Phosphorylation | 378 |
| S | Phosphorylation | 378 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 4286 | MITF | 1138 | NP_937802.1 | in vitro;in vivo;yeast 2-hybrid | 11751862 |
| 6047 | RNF4 | 4167 | NP_002929.1 | in vitro;in vivo;yeast 2-hybrid | 1 071 310 511 719 510 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00651 | 30-159 | BTB |
| cl02518 | 30-159 | BTB superfamily |
| smart00225 | 42-159 | BTB |
| pfam13465 | 369-394 | zf-H2C2_2 |
| cl22375 | 369-394 | zf-H2C2_2 superfamily |
| COG4049 | 600-635 | COG4049 |
| cl20182 | 600-635 | COG4049 superfamily |
| COG5048 | 381-518 | COG5048 |
| COG5048 | 357-408 | COG5048 |
| COG5189 | 379-436 | SFP1 |
| COG5189 | 329-406 | SFP1 |
Ontology Information
| HPRD ID | 9397 |
|---|---|
| Molecular Class | Transcription regulatory protein |
| Molecular Function | Transferase activity (GO:0016740) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091) |
Drug Information
No matching records could be found.