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General Information
- Evidence
- Gene
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- Enzyme
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24185687 | 2014 | Cell line : Caco 2, SW480 Source : - Sample Type : - No. of Sample : - Stage : - | Tissue microarray immunohistochemistry and Western blotting,Real-time RT-PCR , Luciferase reporter assay | Up-regulation | - | Novel target of miR-7, PAX6 may serve as a promising therapeutic target for colorectal cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Paired boxes, "Homeoboxes / PRD class" |
| Description | This gene encodes a homeobox and paired domain-containing protein that binds DNA and functions as a regulator of transcription. Activity of this protein is key in the development of neural tissues, particularly the eye. This gene is regulated by multiple enhancers located up to hundreds of kilobases distant from this locus. Mutations in this gene or in the enhancer regions can cause ocular disorders such as aniridia and Peter's anomaly. Use of alternate promoters and alternative splicing result in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2015] | Chromosome | 11 |
| Location | 11p13 |
| Start | 31806340 |
| End | 31839509 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 33170 |
| OMIM ID | 607108 |
| HGNC ID | HGNC:8620 |
| Unigene ID | Hs.270303 |
| Ensembl ID | ENSG00000007372 |
| PharmGKB ID | PA32960 |
mRNA Information
| mRNA ID | XM_005252865.2 |
|---|---|
| Exon | complement(<32710..>33170) | mRNA Sequence | Download Select all |
| Length | 3034 |
Protein Information
| Protein ID | XP_005252922.1 |
|---|---|
| Protein Name | paired box 6 |
| Molecular Wt. (Da) | 47059 |
| Protein Sequence | Download Select all |
| Length | 425 |
| Uniprot ID | Q01831 |
| Ensembl Protein ID | ENSP00000285021 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 295 |
| T | Phosphorylation | 317 |
| T | Phosphorylation | 387 |
| T | Phosphorylation | 281 |
| T | Phosphorylation | 304 |
| T | Phosphorylation | 373 |
| S | Phosphorylation | 230 |
| S | Phosphorylation | 216 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1045 | CDX2 | 2622 | NP_001256.2 | in vitro;in vivo | 10506141 |
| 1739 | DLG1 | 3007 | NP_004078.2 | in vitro | 16637659 |
| 3211 | HOXB1 | 855 | NP_002135.2 | in vitro | 11069920 |
| 4097 | MAFG | 3605 | NP_002350.1 | in vitro;in vivo | 11036080 |
| 4286 | MITF | 1138 | NP_937802.1 | in vivo | 11350962 |
| 5998 | RGS3 | 3720 | NP_652759.3 | in vitro | 16637659 |
| 6496 | SIX3 | 4756 | NP_005404.1 | in vivo | 11069920 |
| 6658 | SOX3 | 2432 | NP_005625.2 | in vitro | 12710953 |
| 6908 | TBP | 2511 | NP_003185.1 | in vitro;in vivo | 10359315 |
| 8655 | DYNLL1 | 3334 | NP_003737.1 | yeast 2-hybrid | 16098226 |
| 9454 | HOMER3 | 7270 | NP_004829.3 | yeast 2-hybrid | 16098226 |
| 10207 | INADL | 4434 | NP_733750.2 | in vitro | 16637659 |
| 30062 | RAX | 3530 | NP_038463.2 | in vitro;in vivo | 11069920 |
| 81559 | TRIM11 | 7429 | NP_660215.1 | yeast 2-hybrid | 16098226 |
| 85358 | SHANK3 | 18979 | NP_001073889.1 | in vitro | 16637659 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Maturity onset diabetes of the young | hsa04950 |
| Signaling pathways regulating pluripotency of stem cells | hsa04550 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00131 | 5-131 | PAX |
| cl21459 | 5-131 | HTH superfamily |
| cd00086 | 212-269 | homeodomain |
| cl00084 | 212-269 | homeodomain superfamily |
| smart00351 | 4-128 | PAX |
| pfam00292 | 4-128 | PAX |
| pfam00046 | 212-267 | Homeobox |
| smart00389 | 211-266 | HOX |
| cd00090 | 18-75 | HTH_ARSR |
| pfam13384 | 26-64 | HTH_23 |
| pfam13551 | 26-128 | HTH_29 |
| COG5576 | 185-288 | COG5576 |
| pfam03999 | 199-417 | MAP65_ASE1 |
Ontology Information
| HPRD ID | 2656 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | DNA binding (GO:0003677) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.