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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21984339 | 2012 | Cell line : HT29 , Lovo Source : microRNA chip database Sample Type : - No. of Sample : - Stage : - | luciferase reporters Assay,cell migration and invasion assay | Up-regulation | - | let-7c, apart from its tumour growth suppression role, also functions as a tumour metastasis suppressor in colorectal cancer by directly destabilizing the mRNAs of MMP11 and PBX3 at least. |
| 25561793 | 2014 | Cell line : HT 29, RKO, LOVO, SW480, HCT8 Source : ATCC, Beijing Cancer Hospital Sample Type : - No. of Sample : 111 Stage : TNM Stage I-IV | Wound healing and Boyden chamber assays,Western blotting ,real time RT-PCR | Up-regulation | - | PBX3 induces invasion and metastasis of CRC cells partially through activation of the MAPK/ERK signaling pathway. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Homeoboxes / TALE class |
| Description | - | Chromosome | 9 |
| Location | 9q33.3 |
| Start | 128509617 |
| End | 128729656 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 220040 |
| OMIM ID | 176312 |
| HGNC ID | HGNC:8634 |
| Unigene ID | Hs.428027 |
| Ensembl ID | ENSG00000167081 |
| PharmGKB ID | PA32972 |
mRNA Information
| mRNA ID | NM_006195.5 |
|---|---|
| Exon | join(1..316,1213..1286,168349..168590,182318..182508, 188135..188270,213347..213512,214765..214877, 215675..215764,218494..220040) | mRNA Sequence | Download Select all |
| Length | 2911 |
Protein Information
| Protein ID | NP_006186.1 |
|---|---|
| Protein Name | pre-B-cell leukemia homeobox 3 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 434 |
| Uniprot ID | P18887 |
| Ensembl Protein ID | ENSP00000262887 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 3218 | HOXB8 | 851 | NP_076921.1 | in vivo | 11571641 |
| 4211 | MEIS1 | 3442 | NP_002389.1 | in vitro | 15466398 |
| 57085 | AGTRAP | 16379 | NP_065083.3 | yeast 2-hybrid | 16189514 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Transcriptional misregulation in cancer | hsa05202 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00086 | 236-296 | homeodomain |
| cl00084 | 236-296 | homeodomain superfamily |
| pfam03792 | 42-234 | PBC |
| cl04264 | 42-234 | PBC superfamily |
| pfam00046 | 236-295 | Homeobox |
| smart00389 | 236-294 | HOX |
| pfam05920 | 254-292 | Homeobox_KN |
| COG5576 | 234-303 | COG5576 |
Ontology Information
| HPRD ID | 7201 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | DNA binding (GO:0003677) |
| Biological Process | DNA repair (GO:0006281) |
Drug Information
No matching records could be found.