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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
PCBP2 5094 Poly(rC) binding protein 2  12HNRPE2; hnRNP-E2 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
20089989   2010Cell line : -

Source : VU University Medical Center, Amsterdam, The Netherlands.

Sample Type : CRC tumor and normal tissue

No. of Sample : -

Stage : -

Biochemical isolation to nano-LC-MS/MS analysisDown-regulation--


Gene Details



Chromosome: 12; NC_000012.11 (53845886..53874946)

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Gene Type protein coding
Gene Family -
Description The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. Thsi gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]  
Chromosome 12
Location 12q13.12-q
Start 53452102  
End 53481162  
Strand +  
Gene Sequence

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Length 29061  
OMIM ID 601210   
HGNC ID HGNC:8648   
Unigene ID Hs.546271    
Ensembl ID ENSG00000197111   
PharmGKB ID -   

mRNA Information


mRNA ID NM_005016.5
Exon join(1..275,2625..2768,3246..3269,3360..3392,3784..3900, 7171..7302,8914..9042,10380..10466,12659..12751, 13831..13872,15120..15192,15704..15742,16676..16731, 19537..19706,27305..29061)  
mRNA Sequence

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Length 3187  



CDS Information


   
Locationjoin(2700..2768,3246..3269,3360..3392,3784..3900, 7171..7302,8914..9042,10380..10466,12659..12751, 13831..13872,15120..15192,15704..15742,16676..16731, 19537..19706,27305..27341)
CDS Sequence

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CCDS ID CCDS44900.1



Protein Information


      
Protein IDNP_001092090.1
Protein NamePoly(rC) binding protein 2
Molecular Wt. (Da)34786
Protein Sequence

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Length 331  
Uniprot IDQ15417
Ensembl Protein ID ENSP00000359225  



Post-translational Modification Information (Source : HPRD)


Residue Type site
YPhosphorylation236
YPhosphorylation232
YPhosphorylation201
SPhosphorylation173;-
YPhosphorylation182;-
YPhosphorylation178;-
SPhosphorylation189;-
SPhosphorylation185;-
SPhosphorylation188;-
SPhosphorylation184;-
SPhosphorylation187
SPhosphorylation183
SPhosphorylation271
SPhosphorylation267
SPhosphorylation236
SPhosphorylation272
SPhosphorylation268
SPhosphorylation237
SPhosphorylation365
SPhosphorylation361
SPhosphorylation330
TPhosphorylation13
TPhosphorylation15
TPhosphorylation13
TPhosphorylation15
TPhosphorylation13
TPhosphorylation15
SPhosphorylation169
SPhosphorylation169
TPhosphorylation169
SPhosphorylation171
TPhosphorylation175

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                         
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
2316FLNA2060NP_001104026.1yeast 2-hybrid8871564   
3190HNRNPK2834NP_002131.2in vitro;in vivo;yeast 2-hybrid10772858   
4904YBX11095NP_004550.2yeast 2-hybrid8871564   
5725PTBP12823NP_002810.1in vitro;in vivo;yeast 2-hybrid10772858   
6432SFRS78991AAH22328.1in vivo;yeast 2-hybrid8871564   
9444QKI6691NP_006766.1yeast 2-hybrid16713569   
55660PRPF40A10995NP_060362.3yeast 2-hybrid15231748   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0239699-163  PCBP_like_KH
cl0009899-163  KH-I superfamily
cd0239615-76  PCBP_like_KH
cl0009815-76  KH-I superfamily
cd00105289-351  KH-I
cl00098289-351  KH-I superfamily
cd0010599-163  KH-I
cd0010515-75  KH-I
smart0032215-79  KH
smart00322288-351  KH
pfam00013289-351  KH_1
cd02396294-351  PCBP_like_KH
smart0032297-162  KH
pfam13014298-339  KH_3
pfam0001315-75  KH_1
pfam0001399-162  KH_1
pfam13014108-150  KH_3
pfam1301425-63  KH_3
cd0239427-75  vigilin_like_KH
cd02394291-348  vigilin_like_KH
cd0239499-163  vigilin_like_KH
cd0239525-49  SF1_like-KH
cd0239325-75  PNPase_KH
COG019524-133  NusA
PRK1182425-77  PRK11824


Ontology Information


   
HPRD ID363
Molecular ClassRNA binding protein
Molecular FunctionExtracellular matrix structural constituent (GO:0005201)
Biological ProcessCell growth and/or maintenance (GO:0008151)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO