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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
PCCA 5095 propionyl CoA carboxylase, alpha polypeptide  13- 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
9311592   1997Cell line : -

Source : -

Sample Type : CRC tumor and normal tissue

No. of Sample : 10

Stage : -

 in situ hybridization ,Confocal microscopy and quantitative analysisDown-regulation-In all cases, the levels of mRNA were lower in colorectal cancers than in normal mucosae.


Gene Details



NC_000013.10 (100741269..101182691)

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Gene Type protein coding
Gene Family -
Description The protein encoded by this gene is the alpha subunit of the heterodimeric mitochondrial enzyme Propionyl-CoA carboxylase. PCCA encodes the biotin-binding region of this enzyme. Mutations in either PCCA or PCCB (encoding the beta subunit) lead to an enzyme deficiency resulting in propionic acidemia. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]  
Chromosome 13
Location 13q32
Start 100741269  
End 101182691  
Strand +  
Gene Sequence

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Length 441423  
OMIM ID 232000   
HGNC ID HGNC:8653   
Unigene ID Hs.80741   
Ensembl ID ENSG00000175198   
PharmGKB ID PA32992   

mRNA Information


mRNA ID NM_000282.3
Exon join(1..211,13869..13946,22827..22874,22979..23047, 65965..66078,68273..68326,120318..120449,146828..146864, 168581..168659,173715..173817,179675..179769, 184182..184332,212446..212589,213910..213984, 218178..218246,220819..220894,241547..241657, 251143..251245,279458..279560,336619..336717, 360238..360291,426413..426553,438661..438738, 441084..441423)  
mRNA Sequence

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Length 2577  



CDS Information


   
Location 107..2293
CDS Sequence

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CCDS ID CCDS45065.1



Protein Information


      
Protein IDNP_000273.2
Protein Namepropionyl CoA carboxylase, alpha polypeptide
Molecular Wt. (Da)60391
Protein Sequence

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Length 728  
Uniprot IDO43543
Ensembl Protein ID ENSP00000352271  



Post-translational Modification Information (Source : HPRD)


Residue Type site
TPhosphorylation632
YPhosphorylation634

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


                              
Pathway Name Pathway ID
Carbon metabolism hsa01200
Glyoxylate and dicarboxylate metabolism hsa00630
Metabolic pathways hsa01100
Propanoate metabolism hsa00640
Valine, leucine and isoleucine degradation hsa00280


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd06850661-727  biotinyl_domain
cl11404661-727  Biotinyl_lipoyl_domains superfamily
pfam02786176-385  CPSase_L_D2
cl17255176-385  ATP-grasp_4 superfamily
pfam0028963-170  CPSase_L_chain
cl0283763-170  CPSase_L_chain superfamily
smart00878397-504  Biotin_carb_C
cl08365397-504  Biotin_carb_C superfamily
pfam02785397-504  Biotin_carb_C
pfam00364661-727  Biotin_lipoyl
PRK08225660-728  PRK08225
PRK06549661-725  PRK06549
cd06849668-727  lipoyl_domain
cd06663668-727  Biotinyl_lipoyl_domains
pfam13535173-354  ATP-grasp_4
PRK07051662-728  PRK07051
PRK05889662-724  PRK05889
pfam07478183-352  Dala_Dala_lig_C
pfam13549179-220  ATP-grasp_5
pfam08443175-375  RimK
pfam13533659-697  Biotin_lipoyl_2
pfam02258576-629  SLT_beta
cl20230576-629  SLT_beta superfamily
COG477063-728  PccA
PRK0859162-504  PRK08591
PRK0611163-522  PRK06111
PRK0865463-506  PRK08654
COG043963-507  AccC
TIGR0051463-504  accC
PRK0558663-506  PRK05586
PRK1299960-506  PRK12999
TIGR0271263-509  urea_carbox
PRK1283361-504  PRK12833
COG103861-506  PycA
PRK0717863-504  PRK07178
PRK0846265-505  PRK08462
TIGR0123565-513  pyruv_carbox
PRK0846363-504  PRK08463
PRK12999664-728  PRK12999
COG0511661-728  AccB
PRK09282581-728  PRK09282
COG1038665-728  PycA
COG045872-397  CarB
PRK05641661-727  PRK05641
TIGR0136978-383  CPSaseII_lrg
TIGR01235664-728  pyruv_carbox
PRK14040664-727  PRK14040
PRK01372173-352  ddl
TIGR02712654-728  urea_carbox
TIGR01108664-724  oadA
PRK06302661-718  PRK06302
PRK14042666-728  PRK14042
TIGR01205163-352  D_ala_D_alaTIGR
PRK05294153-274  carB
PRK12815164-379  carB
TIGR00531662-728  BCCP
TIGR0136958-354  CPSaseII_lrg
PLN02983663-707  PLN02983
TIGR01348668-728  PDHac_trf_long
PRK01966163-352  ddl
pfam1563294-353  ATPgrasp_Ter
TIGR01348668-728  PDHac_trf_long
PRK11855670-728  PRK11855
COG1181120-353  DdlA
COG0508668-728  AceF
PLN02735166-281  PLN02735
PRK12815156-382  carB
PRK12767105-353  PRK12767
PRK11855670-728  PRK11855
TIGR02144153-278  LysX_arch
PRK0529475-282  carB
COG002683-341  PurK
PRK0601983-265  PRK06019
TIGR03909213-386  pyrrolys_PylC
PTZ00144668-727  PTZ00144
PRK11856668-728  PRK11856
PLN02735129-389  PLN02735
PRK14875668-724  PRK14875
PRK14016197-264  PRK14016
PRK11854668-728  aceF
PRK11854668-728  aceF
TIGR01108573-685  oadA
COG0511662-692  AccB
TIGR01161156-339  purK
PRK11854668-728  aceF


Ontology Information


   
HPRD ID15951
Molecular ClassEnzyme: Carboxylase
Molecular FunctionDNA repair protein (GO:0003685)
Biological ProcessDNA repair (GO:0006281)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
P05165DB00121BiotinSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
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