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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23180019 | 2013 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Methylation-specific PCR | Methylation | - | PCDH10 methylation may constitute a useful biomarker of colorectal cancer patients. PCDH10 is an important tumor suppression gene with key roles of suppressing cell proliferation, clonogenicity, and inhibiting cell invasion in the development of colorectal cancer. 100 % (8 of 8) of colorectal cancer cell lines were silenced for PCDH10, but not normal colorectal epithelial cells. |
| 22926751 | 2013 | Cell line : - Source : - Sample Type : GC and CRC tumor and normal tissue No. of Sample : - Stage : - | - | Methylation | - | PCDH17 methylation is a tumour-specific event that could serve as an epigenetic biomarker for these tumours. PCDH17 acts as a tumour suppressor, exerting its anti-proliferative activity through inducing apoptosis and autophagy, and is frequently silenced in gastric and colorectal cancers. PCDH17 was frequently silenced and methylated in almost all gastric and colorectal tumour cell lines as well as in ?95% of primary tumours, but not in normal gastric and colonic mucosa. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Cadherins / Protocadherins : Non-clustered |
| Description | This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein contains six extracellular cadherin domains, a transmembrane domain, and a cytoplasmic tail differing from those of the classical cadherins. The encoded protein may play a role in the establishment and function of specific cell-cell connections in the brain. | Chromosome | 13 |
| Location | 13q21.1 |
| Start | 57630104 |
| End | 57729311 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 99208 |
| OMIM ID | 611760 |
| HGNC ID | HGNC:14267 |
| Unigene ID | Hs.106511 |
| Ensembl ID | ENSG00000118946 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | XM_005266358.1 |
|---|---|
| Exon | join(1..5008,36365..36423,36561..36730,94509..99208) | mRNA Sequence | Download Select all |
| Length | 8009 |
CDS Information
| Location | join(2444..5008,36365..36423,36558..36730,94509..95191) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | - |
Protein Information
| Protein ID | NP_001035519.1 |
|---|---|
| Protein Name | protocadherin 17 |
| Molecular Wt. (Da) | 124300 |
| Protein Sequence | Download Select all |
| Length | 1159 |
| Uniprot ID | O00410 |
| Ensembl Protein ID | ENSP00000261574 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 56893 | UBQLN4 | 5670 | NP_064516.2 | yeast 2-hybrid | 16713569 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd11304 | 247-347 | Cadherin_repeat |
| cl15786 | 247-347 | CA_like superfamily |
| cd11304 | 477-579 | Cadherin_repeat |
| cl15786 | 477-579 | CA_like superfamily |
| cd11304 | 141-239 | Cadherin_repeat |
| cl15786 | 141-239 | CA_like superfamily |
| cd11304 | 361-468 | Cadherin_repeat |
| cl15786 | 361-468 | CA_like superfamily |
| cd11304 | 594-682 | Cadherin_repeat |
| cl15786 | 594-682 | CA_like superfamily |
| cd11304 | 22-128 | Cadherin_repeat |
| cl15786 | 22-128 | CA_like superfamily |
| smart00112 | 266-349 | CA |
| smart00112 | 496-581 | CA |
| pfam00028 | 248-342 | Cadherin |
| smart00112 | 155-241 | CA |
| smart00112 | 375-470 | CA |
| smart00112 | 611-682 | CA |
| pfam00028 | 137-234 | Cadherin |
| pfam00028 | 596-681 | Cadherin |
| pfam00028 | 477-574 | Cadherin |
| pfam08266 | 21-112 | Cadherin_2 |
| pfam00028 | 357-463 | Cadherin |
| smart00112 | 64-130 | CA |
| cd00031 | 253-347 | CA_like |
| TIGR01965 | 492-589 | VCBS_repeat |
| cl11690 | 492-589 | VCBS_repeat superfamily |
| pfam00028 | 22-94 | Cadherin |
Ontology Information
| HPRD ID | 1817 |
|---|---|
| Molecular Class | Adhesion molecule |
| Molecular Function | GTPase activity (GO:0003924) |
| Biological Process | Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.