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General Information
- Evidence
- Gene
- mRNA
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- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24704829 | 2015 | Cell line : HEK293T Source : American Type Culture Collection (ATCC). Sample Type : - No. of Sample : - Stage : - | - | Up-regulation | - | Novel role of PDE10 in colon tumorigenesis and that inhibitors may be useful for the treatment or prevention of colorectal cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Phosphodiesterases |
| Description | The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP and cGMP to the corresponding nucleoside 5' monophosphate, but has higher affinity for cAMP, and is more efficient with cAMP as substrate. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Dec 2011 | Chromosome | 6 |
| Location | 6q26 |
| Start | 165740776 |
| End | 166075588 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 334813 |
| OMIM ID | 610652 |
| HGNC ID | HGNC:8772 |
| Unigene ID | Hs.348762 |
| Ensembl ID | ENSG00000112541 |
| PharmGKB ID | PA33120 |
Protein Information
| Protein ID | NP_001124162.1 |
|---|---|
| Protein Name | phosphodiesterase 10A |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 779 |
| Uniprot ID | O60687 |
| Ensembl Protein ID | ENSP00000362095 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 767 |
| S | Phosphorylation | 766 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 836 | CASP3 | 2799 | NP_004337.2 | in vitro | 11602184 |
| 10885 | WDR3 | 16066 | NP_006775.1 | yeast 2-hybrid | 16169070 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Morphine addiction | hsa05032 |
| Purine metabolism | hsa00230 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00077 | 514-687 | HDc |
| cl21469 | 514-687 | HDc superfamily |
| pfam00233 | 514-748 | PDEase_I |
| smart00065 | 267-422 | GAF |
| cl21515 | 267-422 | GAF superfamily |
| pfam01590 | 267-412 | GAF |
| pfam13492 | 267-413 | GAF_3 |
| pfam13185 | 267-413 | GAF_2 |
| smart00471 | 513-672 | HDc |
| COG2203 | 268-425 | FhlA |
| COG2203 | 142-247 | FhlA |
| cl21515 | 142-247 | GAF superfamily |
| smart00065 | 91-236 | GAF |
| COG1956 | 322-398 | GAF |
Ontology Information
| HPRD ID | 7070 |
|---|---|
| Molecular Class | Enzyme: Phosphodiesterase |
| Molecular Function | Metallopeptidase activity (GO:0008237) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| Q9Y233 | DB00201 | Caffeine | SmallMoleculeDrug |
| Q9Y233 | DB00975 | Dipyridamole | SmallMoleculeDrug |
| Q9Y233 | DB01113 | Papaverine | SmallMoleculeDrug |
| Q9Y233 | DB08811 | Tofisopam | SmallMoleculeDrug |
| Q9Y233 | DB08814 | Triflusal | SmallMoleculeDrug |