Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| PDK1 | 5163 | pyruvate dehydrogenase kinase, isozyme 1 | 2 | - |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 26055151 | 2015 | Cell line : DLD1,HCT8,HCT116,SW480,SW620, LOVO Source : ATCC Sample Type : - No. of Sample : - Stage : - | Immunohistochemistry,real time RT-PCR,MTT assay, Colony formation assay,si RNA interference and Transfection, Western Blotting | Up-regulation | - | PDK1 in colorectal cellular functions trigged by the Akt/cyclin D1 pathway, thus providing a novel insight of PDK1 in colorectal carcinogenesis. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2013] | Chromosome | 2 |
| Location | 2q31.1 |
| Start | 173420101 |
| End | 173490351 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 70251 |
| OMIM ID | 602524 |
| HGNC ID | HGNC:8809 |
| Unigene ID | Hs.470633 |
| Ensembl ID | ENSG00000152256 |
| PharmGKB ID | PA33154 |
mRNA Information
| mRNA ID | XM_011511343.1 |
|---|---|
| Exon | join(6..347,3336..3477,6848..6919,7369..7428,9131..9315, 9606..9701,11484..11561,13369..13445,15354..15452, 30906..31016,37563..37676,40457..43458) | mRNA Sequence | Download Select all |
| Length | 4378 |
Protein Information
| Protein ID | XP_011509645.1 |
|---|---|
| Protein Name | pyruvate dehydrogenase kinase, isozyme 1 |
| Molecular Wt. (Da) | 47912 |
| Protein Sequence | Download Select all |
| Length | 380 |
| Uniprot ID | P62258 |
| Ensembl Protein ID | ENSP00000264335 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 25 |
| S | Phosphorylation | 393 |
| S | Phosphorylation | 396 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 5160 | PDHA1 | 2420 | NP_000275.1 | in vitro | 126 766 471 148 600 000 000 000 |
| 6198 | RPS6KB1 | 10202 | NP_003152.1 | in vitro;in vivo | 11279232 |
| 10971 | YWHAQ | 886 | NP_006817.1 | in vivo | 19010391 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Central carbon metabolism in cancer | hsa05230 |
| HIF-1 signaling pathway | hsa04066 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00075 | 273-389 | HATPase_c |
| cl00075 | 273-389 | HATPase_c superfamily |
| pfam10436 | 55-221 | BCDHK_Adom3 |
| cl11087 | 55-221 | BCDHK_Adom3 superfamily |
| smart00387 | 270-390 | HATPase_c |
| pfam02518 | 269-390 | HATPase_c |
| COG0642 | 224-398 | BaeS |
| COG5002 | 258-383 | VicK |
| COG1389 | 273-371 | COG1389 |
| PRK11091 | 263-391 | PRK11091 |
| TIGR01052 | 273-389 | top6b |
| PRK11360 | 280-396 | PRK11360 |
| COG2205 | 262-389 | KdpD |
| PRK11100 | 301-387 | PRK11100 |
| PRK15347 | 301-383 | PRK15347 |
| TIGR02956 | 270-383 | TMAO_torS |
| TIGR01058 | 252-358 | parE_Gpos |
| COG3290 | 270-389 | CitA |
Ontology Information
| HPRD ID | 2445 |
|---|---|
| Molecular Class | Enzyme: Phosphotransferase |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.