Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| PDK3 | 5165 | pyruvate dehydrogenase kinase, isozyme 3 | X | - |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21763680 | 2011 | Cell line : - Source : National Cheng Kung University Hospital Sample Type : CRC tumor No. of Sample : 349 Stage : - | Western Blotting,Immunohistochemistry, real time RT-PCR,Transfection, and Promoter Activity Assay,Site-Directed Mutagenesis,TUNEL Assay | Up-regulation | - | PDK3 plays an important role in the metabolic switch and drug resistance of colon cancer and is potentially a novel target for cancer therapy. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle, and thus is one of the major enzymes responsible for the regulation of glucose metabolism. The enzymatic activity of PDH is regulated by a phosphorylation/dephosphorylation cycle, and phosphorylation results in inactivation of PDH. The protein encoded by this gene is one of the three pyruvate dehydrogenase kinases that inhibits the PDH complex by phosphorylation of the E1 alpha subunit. This gene is predominantly expressed in the heart and skeletal muscles. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010] | Chromosome | X |
| Location | Xp22.12 |
| Start | 24483344 |
| End | 24568583 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 85240 |
| OMIM ID | 300906 |
| HGNC ID | HGNC:8811 |
| Unigene ID | Hs.296031 |
| Ensembl ID | ENSG00000067992 |
| PharmGKB ID | PA33156 |
mRNA Information
| mRNA ID | NM_001142386.2 |
|---|---|
| Exon | join(1..335,29516..29657,33603..33674,38101..38285, 39983..40072,53707..53784,60972..61048,62348..62449, 62850..62960,66431..66544,68703..68842,73908..85240) | mRNA Sequence | Download Select all |
| Length | 12795 |
Protein Information
| Protein ID | NP_001135858.1 |
|---|---|
| Protein Name | pyruvate dehydrogenase kinase, isozyme 3 |
| Molecular Wt. (Da) | 99994 |
| Protein Sequence | Download Select all |
| Length | 415 |
| Uniprot ID | P43403 |
| Ensembl Protein ID | ENSP00000264972 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 5160 | PDHA1 | 2420 | NP_000275.1 | in vitro | 126 766 471 148 600 000 000 000 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00075 | 241-358 | HATPase_c |
| cl00075 | 241-358 | HATPase_c superfamily |
| pfam10436 | 25-189 | BCDHK_Adom3 |
| cl11087 | 25-189 | BCDHK_Adom3 superfamily |
| pfam02518 | 237-359 | HATPase_c |
| smart00387 | 238-359 | HATPase_c |
| COG0642 | 220-365 | BaeS |
| PRK11360 | 277-365 | PRK11360 |
| COG5002 | 85-352 | VicK |
| PRK13837 | 222-358 | PRK13837 |
| PRK11091 | 278-352 | PRK11091 |
Ontology Information
| HPRD ID | 2718 |
|---|---|
| Molecular Class | Enzyme: Phosphotransferase |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.