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General Information

• Evidence
• Gene
• mRNA
• CDS
• Protein
• PTM
• Enzyme
• PPi
• Pathway
• Structural
• Domain
• Ontology
• SNP
• Drug
• External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
23850494	2013	Cell line : - Source : - Sample Type : CRCand GC tumor and normal tissue No. of Sample : 91 gastric cancers and 100 colorectal cancers with high microsatellite instability or stable/low microsatellite instability. Stage : -	Immunohistochemistry,SSCP, DNA sequencing	Mutation/ Downregulation	-	Frameshift mutations of SGOL1 and PDS5B and the loss of their expression may be a feature of gastric and colorectal cancers with high microsatellite instability.

Gene Details

NC_000013.10 (33160564..33352158)
View Larger Image   

Gene Type	protein coding
Gene Family	-
Description	This gene encodes a protein that interacts with the conserved protein complex termed cohesin. The cohesin complex holds together sister chromatids and facilitates accurate chromosome segregation during mitosis and meiosis. This protein is also a negative regulator of cell proliferation and may be a tumor-suppressor gene. [provided by RefSeq, Jul 2015]
Chromosome	13
Location	13q12.3
Start	33160564
End	33352158
Strand	+
Gene Sequence	Download   Select all
Length	191595
OMIM ID	605333
HGNC ID	HGNC:20418
Unigene ID	Hs.744901
Ensembl ID	ENSG00000083642
PharmGKB ID	PA162399098

mRNA Information

mRNA ID	?NM_015032.3
Exon
mRNA Sequence	Download   Select all
Length

CDS Information

   

Location
CDS Sequence	Download   Select all
CCDS ID	CCDS41878.1

Protein Information

      

Protein ID	NP_055847.1
Protein Name	PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
Molecular Wt. (Da)	0
Protein Sequence	Download   Select all
Length	1447
Uniprot ID	Q8IY34
Ensembl Protein ID	ENSP00000227880

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
S	Phosphorylation	1166
S	Phosphorylation	1358
S	Phosphorylation	1383
T	Phosphorylation	1367;-
S	Phosphorylation	1257;-
S	Phosphorylation	1257;-
S	Phosphorylation	1259;-
S	Phosphorylation	1259;-
S	Phosphorylation	1383;-
Y	Phosphorylation	1187;-
T	Phosphorylation	1188;-
Y	Phosphorylation	1187;-
T	Phosphorylation	1188;-
S	Phosphorylation	1182;-
S	Phosphorylation	1182;-
S	Phosphorylation	1177;-
S	Phosphorylation	1177;-
T	Phosphorylation	1255;-
T	Phosphorylation	1255;-
S	Phosphorylation	1283
S	Phosphorylation	1283
S	Phosphorylation	1319
S	Phosphorylation	1319
S	Phosphorylation	1334
S	Phosphorylation	1334
S	Phosphorylation	1361
T	Phosphorylation	1370
S	Phosphorylation	1162
S	Phosphorylation	1165
K	Acetylation	1136
K	Acetylation	1136
K	Acetylation	417
K	Acetylation	417
S	Phosphorylation	1369
S	Phosphorylation	1161
T	Phosphorylation	1050
T	Phosphorylation	1050
T	Phosphorylation	1235
S	Phosphorylation	1406
T	Phosphorylation	1301
T	Phosphorylation	1301
S	Phosphorylation	1139
S	Phosphorylation	1139
S	Phosphorylation	1417
S	Phosphorylation	1160
S	Phosphorylation	1407
S	Phosphorylation	1176
S	Phosphorylation	1191
S	Phosphorylation	1176
S	Phosphorylation	1190
S	Phosphorylation	1362
T	Phosphorylation	1121
T	Phosphorylation	1121
S	Phosphorylation	1140
S	Phosphorylation	1140
S	Phosphorylation	1366

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information

No matching records could be found.

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
pfam05029	1173-1303	TIMELESS_C
cl22304	1173-1303	TIMELESS_C superfamily
pfam05793	1175-1403	TFIIF_alpha
PTZ00449	1042-1295	PTZ00449
pfam05110	1175-1419	AF-4
pfam10243	1242-1418	MIP-T3
PRK05667	250-461	dnaG
PTZ00449	1215-1410	PTZ00449
pfam10243	1194-1411	MIP-T3

Ontology Information

   

HPRD ID	2296
Molecular Class	Transcription factor
Molecular Function	Receptor activity (GO:0004872)
Biological Process	Innate immune response (GO:0045087)

SNP Information

View SNP Geneview Report   

Drug Information

No matching records could be found.

External Links

                                 

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO