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General Information
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21380491 | 2011 | Cell line : - Source : - Sample Type : CRC tumor and adjacent normal tissue No. of Sample : 202 Stage : - | real time RT-PCR | Up-regulation | - | High expression of the Per2 gene was associated with significantly better outcomes than low expression of the Per2 gene. |
| 22149272 | 2012 | Cell line : CaCo2, SW480 Source : - Sample Type : CRC tumor and adjacent normal tissue No. of Sample : 19 Stage : - | real time RT-PCR, Western blotting | Up-regulation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers. Alternative splicing has been observed in this gene; however, these variants have not been fully described. [provided by RefSeq, Jan 2014] | Chromosome | 17 |
| Location | 17p13.1 |
| Start | 8043788 |
| End | 8059723 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 15936 |
| OMIM ID | 602260 |
| HGNC ID | HGNC:8845 |
| Unigene ID | Hs.445534 |
| Ensembl ID | - |
| PharmGKB ID | PA33184 |
mRNA Information
| mRNA ID | XM_005256689.1 |
|---|---|
| Exon | join(1..99,5561..5974,6089..6187,6281..6435,6530..6651, 6743..6944,7096..7147,7620..7762,8147..8225,8303..8409, 8579..8732,8828..8936,9025..9156,9404..9509,9641..9812, 9904..10034,10269..10448,11413..11655,12530..13140, 13571..13757,13948..14137,14451..14601,15066..15936) | mRNA Sequence | Download Select all |
| Length | 4709 |
Protein Information
| Protein ID | XP_005256746.1 |
|---|---|
| Protein Name | period circadian clock 1 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 1290 |
| Uniprot ID | Q15915 |
| Ensembl Protein ID | ENSP00000282928 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 1262;- |
| S | Phosphorylation | 1263;- |
| S | Phosphorylation | 979;- |
| S | Phosphorylation | 980;- |
| S | Phosphorylation | 1104;- |
| S | Phosphorylation | 1100;- |
| S | Phosphorylation | 1103;- |
| S | Phosphorylation | 704 |
| S | Phosphorylation | 815 |
| S | Phosphorylation | 1186 |
| S | Phosphorylation | 1279 |
| T | Phosphorylation | 161 |
| T | Phosphorylation | 164 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1453 | CSNK1D | 2920 | NP_001884.2 | in vitro;in vivo | 11165242 |
| 1454 | CSNK1E | 2919 | NP_001885.1 | in vitro;in vivo | 1 084 861 411 865 040 |
| 9737 | GPRASP1 | 2333 | NP_055525.3 | in vitro;in vivo;yeast 2-hybrid | 11597585 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Circadian entrainment | hsa04713 |
| Circadian rhythm | hsa04710 |
| Herpes simplex infection | hsa05168 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00130 | 360-461 | PAS |
| cl21578 | 360-461 | PAS superfamily |
| pfam12114 | 1083-1231 | Period_C |
| cl13540 | 1083-1231 | Period_C superfamily |
| smart00091 | 360-414 | PAS |
| pfam14598 | 360-461 | PAS_11 |
| pfam08447 | 373-457 | PAS_3 |
| pfam00989 | 373-458 | PAS |
| PHA03247 | 765-1025 | PHA03247 |
| PHA03247 | 891-965 | PHA03247 |
| PRK12323 | 893-1022 | PRK12323 |
| PRK12323 | 818-1026 | PRK12323 |
| TIGR00229 | 370-457 | sensory_box |
Ontology Information
| HPRD ID | 3540 |
|---|---|
| Molecular Class | Transcription regulatory protein |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.