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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24587674 | 2014 | Cell line : - Source : - Sample Type : Transgenic mice. No. of Sample : - Stage : - | - | Down-regulation | - | Decreased expression of negative regulators such as PER2 and PER3 is connected with poorer differentiation, increased aggressiveness and worse prognosis. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been linked to sleep disorders. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2014] | Chromosome | 1 |
| Location | 1p36.23 |
| Start | 7844413 |
| End | 7905241 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 60829 |
| OMIM ID | 603427 |
| HGNC ID | HGNC:8847 |
| Unigene ID | Hs.162200 |
| Ensembl ID | ENSG00000049246 |
| PharmGKB ID | PA33186 |
Protein Information
| Protein ID | NP_001276790.1 |
|---|---|
| Protein Name | period circadian clock 3 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 1201 |
| Uniprot ID | Q9UJ72 |
| Ensembl Protein ID | ENSP00000352248 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 622 |
| S | Phosphorylation | 625 |
| S | Phosphorylation | 628 |
| S | Phosphorylation | 633 |
| S | Phosphorylation | 634 |
| T | Phosphorylation | 635 |
| S | Phosphorylation | 480 |
| T | Phosphorylation | 482 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 406 | ARNTL | 3973 | NP_001169.3 | in vivo | 14701732 |
| 1407 | CRY1 | 9050 | NP_004066.1 | in vivo | 10428031 |
| 1408 | CRY2 | 7226 | NP_066940.2 | in vitro | 14701732 |
| 1453 | CSNK1D | 2920 | NP_001884.2 | in vivo | 11865049 |
| 5187 | PER1 | 3774 | NP_002607.2 | in vitro | 10837028 |
| 6667 | SP1 | 1796 | NP_612482.2 | in vitro;in vivo | 7622044 |
| 8864 | PER2 | 4575 | NP_073728.1 | in vivo | 10837028 |
| 9575 | CLOCK | 3508 | NP_004889.1 | in vivo | 14701732 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Circadian entrainment | hsa04713 |
| Circadian rhythm | hsa04710 |
| Herpes simplex infection | hsa05168 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00130 | 284-376 | PAS |
| cl21578 | 284-376 | PAS superfamily |
| pfam12114 | 988-1186 | Period_C |
| cl13540 | 988-1186 | Period_C superfamily |
| smart00091 | 284-328 | PAS |
| pfam14598 | 274-376 | PAS_11 |
| pfam08447 | 284-372 | PAS_3 |
| pfam03154 | 744-1103 | Atrophin-1 |
| PHA03307 | 745-1057 | PHA03307 |
| pfam00989 | 271-373 | PAS |
| PHA03307 | 741-1055 | PHA03307 |
| PHA03247 | 747-1052 | PHA03247 |
| PHA03247 | 731-1055 | PHA03247 |
| PHA03247 | 747-1054 | PHA03247 |
| PHA03247 | 744-1055 | PHA03247 |
| pfam15402 | 891-1053 | Spc7_N |
| PHA03307 | 931-1078 | PHA03307 |
| PLN02217 | 950-1057 | PLN02217 |
| PHA03379 | 745-1054 | PHA03379 |
| PRK12323 | 751-1007 | PRK12323 |
| pfam03154 | 930-1054 | Atrophin-1 |
| PRK14086 | 784-1012 | dnaA |
| pfam04484 | 958-1056 | DUF566 |
| pfam03154 | 743-1057 | Atrophin-1 |
| pfam05109 | 781-1051 | Herpes_BLLF1 |
| pfam05109 | 950-1085 | Herpes_BLLF1 |
Ontology Information
| HPRD ID | 5853 |
|---|---|
| Molecular Class | Transcription regulatory protein |
| Molecular Function | G-protein coupled receptor activity (GO:0004930) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.