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General Information
- Evidence
- Gene
- mRNA
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- Protein
- PTM
- Enzyme
- PPi
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- Structural
- Domain
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22402885 | 2012 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 35 CRC and 84 healthy controls Stage : - | ELISA, Multivariable logistic regression | Up-regulation | - | Multivariable logistic regression analysis indicated that PDGF, PF4 and VEGF were independent predictors of colorectal carcinoma . |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet aggregation. This protein is chemotactic for numerous other cell type and also functions as an inhibitor of hematopoiesis, angiogenesis and T-cell function. The protein also exhibits antimicrobial activity against Plasmodium falciparum. [provided by RefSeq, Oct 2014] | Chromosome | 4 |
| Location | 4q12-q21 |
| Start | 74846542 |
| End | 74847841 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 1300 |
| OMIM ID | 173460 |
| HGNC ID | HGNC:8861 |
| Unigene ID | Hs.81564 |
| Ensembl ID | ENSG00000163737 |
| PharmGKB ID | PA33203 |
mRNA Information
| mRNA ID | NM_002619.3 |
|---|---|
| Exon | join(1..262,582..708,834..1300) | mRNA Sequence | Download Select all |
| Length | 878 |
Protein Information
| Protein ID | NP_002610.1 |
|---|---|
| Protein Name | platelet factor 4 |
| Molecular Wt. (Da) | 54346 |
| Protein Sequence | Download Select all |
| Length | 101 |
| Uniprot ID | Q15072 |
| Ensembl Protein ID | ENSP00000392095 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| C | Disulfide Bridge | 41;67 |
| C | Disulfide Bridge | 43;83 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2247 | FGF2 | 622 | NP_001997.5 | in vitro;in vivo | 9558385 |
| 6352 | CCL5 | 1751 | NP_002976.2 | in vitro | 15459010 |
| 6383 | SDC2 | 803 | NP_002989.2 | in vitro | 7524669 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Chemokine signaling pathway | hsa04062 |
| Cytokine-cytokine receptor interaction | hsa04060 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00273 | 38-100 | Chemokine_CXC |
| cl00134 | 38-100 | Chemokine superfamily |
| pfam00048 | 43-98 | IL8 |
| cd00169 | 43-99 | Chemokine |
| smart00199 | 38-98 | SCY |
Ontology Information
| HPRD ID | 4272 |
|---|---|
| Molecular Class | Chemokine |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P02776 | DB00055 | Drotrecogin alfa | BiotechDrug |