Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| PFKFB4 | 5210 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 3 | - |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 15925437 | 2005 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : - Stage : - | - | Up-regulation | - | Overexpression of PFKFB-4 mRNA and protein in the breast and colon malignant tumors. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene is one of four bifunctional kinase/phosphatases that regulate the concentration of the glycolytic byproduct fructose-2,6-bisphosphate (F2,6BP). The encoded protein is highly expressed in cancer cells and is induced by hypoxia. This protein is essential to the survival of cancer cells under conditions of hypoxia, because it increases the amount of F2,6BP and ATP at a time when the cell cannot produce much of them. This finding suggests that this protein may be a good target for disruption in cancer cells, hopefully imperiling their survival. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015] | Chromosome | 3 |
| Location | 3p22-p21 |
| Start | 48555117 |
| End | 48598607 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 43491 |
| OMIM ID | 605320 |
| HGNC ID | HGNC:8875 |
| Unigene ID | Hs.476217 |
| Ensembl ID | ENSG00000114268 |
| PharmGKB ID | PA33214 |
mRNA Information
| mRNA ID | XM_011533829.1 |
|---|---|
| Exon | join(3..1188,12541..12657,12815..12911,19129..19195, 23004..23078,23465..23521,24156..24277,26312..26519, 27117..27263,37106..37210,38945..39074,39176..39238, 40725..40789,42969..45091) | mRNA Sequence | Download Select all |
| Length | 4562 |
Protein Information
| Protein ID | XP_011532131.1 |
|---|---|
| Protein Name | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 |
| Molecular Wt. (Da) | 53009 |
| Protein Sequence | Download Select all |
| Length | 471 |
| Uniprot ID | Q9UQR1 |
| Ensembl Protein ID | ENSP00000353863 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| AMPK signaling pathway | hsa04152 |
| Fructose and mannose metabolism | hsa00051 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd07067 | 252-437 | HP_PGM_like |
| cl11399 | 252-437 | HP superfamily |
| pfam01591 | 30-249 | 6PF2K |
| cl21455 | 30-249 | P-loop_NTPase superfamily |
| COG0406 | 249-423 | PhoE |
| pfam00300 | 252-398 | His_Phos_1 |
| smart00855 | 252-398 | PGAM |
| TIGR03162 | 252-430 | ribazole_cobC |
| cd07040 | 252-424 | HP |
| PRK13463 | 251-402 | PRK13463 |
| COG0588 | 254-409 | GpmA |
| PRK15004 | 252-410 | PRK15004 |
| PRK03482 | 252-456 | PRK03482 |
| PTZ00123 | 262-409 | PTZ00123 |
| PRK14120 | 248-398 | gpmA |
| COG2062 | 252-339 | SixA |
| TIGR01258 | 250-402 | pgm_1 |
| PRK01295 | 249-399 | PRK01295 |
| PRK13462 | 254-404 | PRK13462 |
| PRK14119 | 249-410 | gpmA |
| PRK01112 | 254-416 | PRK01112 |
| PRK14116 | 254-401 | gpmA |
| TIGR03848 | 254-403 | MSMEG_4193 |
| PRK14115 | 254-328 | gpmA |
| PRK14117 | 256-326 | gpmA |
| pfam13207 | 41-139 | AAA_17 |
| pfam13671 | 41-196 | AAA_33 |
| PTZ00322 | 2-448 | PTZ00322 |
| PRK07238 | 248-391 | PRK07238 |
| PTZ00122 | 250-411 | PTZ00122 |
Ontology Information
| HPRD ID | 3592 |
|---|---|
| Molecular Class | Enzyme: Phosphatase |
| Molecular Function | Cell adhesion molecule activity (GO:0005194) |
| Biological Process | Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.