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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
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- Drug
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 18097579 | 2008 | Cell line : SW480, SW620 Source : - Sample Type : CRC Tumor and normal tissue No. of Sample : - Stage : - | Bioinformatics tools | Up-regulation | - | Glycolytic pathway and glycolysis-related genes may play an important role in the tumorigenesis of CRC. |
| 18603805 | 2008 | Cell line : HT29 Source : Korean Cell Line Bank (Seoul, Korea). Sample Type : - No. of Sample : - Stage : - | 2-DE,In-gel protein digestion,MALDI-TOF MS,Western blotting | Up-regulation | - | PGK1 might be a potential protein biomarker of intracellular oxidative status. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene is a glycolytic enzyme that catalyzes the conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. The encoded protein may also act as a cofactor for polymerase alpha. Additionally, this protein is secreted by tumor cells where it participates in angiogenesis by functioning to reduce disulfide bonds in the serine protease, plasmin, which consequently leads to the release of the tumor blood vessel inhibitor angiostatin. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Deficiency of the enzyme is associated with a wide range of clinical phenotypes hemolytic anemia and neurological impairment. Pseudogenes of this gene have been defined on chromosomes 19, 21 and the X chromosome. [provided by RefSeq, Jan 2014] | Chromosome | X |
| Location | Xq13.3 |
| Start | 77359666 |
| End | 77382324 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 22659 |
| OMIM ID | 311800 |
| HGNC ID | HGNC:8896 |
| Unigene ID | Hs.78771 |
| Ensembl ID | ENSG00000102144 |
| PharmGKB ID | PA33234 |
mRNA Information
| mRNA ID | NM_000291.3 |
|---|---|
| Exon | join(1..237,5699..5749,9576..9731,9848..9992,13144..13247, 13883..14002,18667..18781,19027..19206,20706..20883, 21159..21257,21622..22659) | mRNA Sequence | Download Select all |
| Length | 2439 |
Protein Information
| Protein ID | NP_000282.1 |
|---|---|
| Protein Name | phosphoglycerate kinase 1 |
| Molecular Wt. (Da) | 141348 |
| Protein Sequence | Download Select all |
| Length | 417 |
| Uniprot ID | Q15942 |
| Ensembl Protein ID | ENSP00000324422 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 196;- |
| S | Phosphorylation | 203;- |
| S | Phosphorylation | 136 |
| K | Acetylation | 156 |
| K | Acetylation | 291 |
| K | Acetylation | 86 |
| K | Acetylation | 91 |
| K | Acetylation | 199 |
| K | Acetylation | 11 |
| K | Acetylation | 146 |
| K | Acetylation | 267 |
| K | Acetylation | 406 |
| K | Acetylation | 323 |
| K | Acetylation | 30 |
| K | Acetylation | 75 |
| K | Acetylation | 131 |
| K | Acetylation | 97 |
| K | Acetylation | 48 |
| C | S-Nitrosylation | 108 |
| S | Phosphorylation | 57 |
| S | Phosphorylation | 62 |
| S | Phosphorylation | 77 |
| S | Phosphorylation | 415 |
| S | Phosphorylation | 390 |
| S | Phosphorylation | 393 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2597 | GAPDH | 713 | NP_002037.2 | in vitro;in vivo | 8075252 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Biosynthesis of amino acids | hsa01230 |
| Carbon metabolism | hsa01200 |
| Glycolysis / Gluconeogenesis | hsa00010 |
| HIF-1 signaling pathway | hsa04066 |
| Metabolic pathways | hsa01100 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00318 | 9-416 | Phosphoglycerate_kinase |
| cl00198 | 9-416 | Phosphoglycerate_kinase superfamily |
| PTZ00005 | 3-417 | PTZ00005 |
| pfam00162 | 8-406 | PGK |
| PRK00073 | 6-416 | pgk |
| COG0126 | 3-416 | Pgk |
| PLN02282 | 8-416 | PLN02282 |
| PLN03034 | 9-414 | PLN03034 |
| PRK13962 | 5-416 | PRK13962 |
Ontology Information
| HPRD ID | 995 |
|---|---|
| Molecular Class | Enzyme: Phosphotransferase |
| Molecular Function | Receptor activity (GO:0004872) |
| Biological Process | Cell communication (GO:0007154); Regulation of signal transduction (GO:0009966) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P00558 | DB00709 | Lamivudine | SmallMoleculeDrug |