Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| PGM1 | 5236 | Phosphoglucomutase 1  | 1 | CDG1T; GSD14  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21531130    | 2011 | Cell line : - Source : Japanees patients Sample Type : CRC tumor and normal tissue No. of Sample : 113 patients primary CRC Stage : - | Peptide Nucleic Acid (PNA)-clamp real-timeRT-PCR TaqMan assay, Gene expression profiles | Up-regulation | - | - |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene is an isozyme of phosphoglucomutase (PGM) and belongs to the phosphohexose mutase family. There are several PGM isozymes, which are encoded by different genes and catalyze the transfer of phosphate between the 1 and 6 positions of glucose. In most cell types, this PGM isozyme is predominant, representing about 90% of total PGM activity. In red cells, PGM2 is a major isozyme. This gene is highly polymorphic. Mutations in this gene cause glycogen storage disease type 14. Alternativley spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Mar 2010]   | Chromosome | 1 |
| Location | 1p31 |
| Start | 63593276   |
| End | 63660245   |
| Strand | +   |
| Gene Sequence |    Download   Select all |
| Length | 66970   |
| OMIM ID | 171900    |
| HGNC ID | HGNC:8905    |
| Unigene ID | Hs.1869     |
| Ensembl ID | ENSG00000079739    |
| PharmGKB ID | -    |
mRNA Information
| mRNA ID | NM_002633.2 |
|---|---|
| Exon | join(1..459,36150..36312,36667..36813,38382..38507, 41554..41744,42959..43113,45410..45525,55242..55377, 58394..58577,61057..61191,66311..66970)   | mRNA Sequence |    Download   Select all |
| Length | 2487   |
CDS Information
| Location | join(214..459,36150..36312,36667..36813,38382..38507, 41554..41744,42959..43113,45410..45525,55242..55377, 58394..58577,61057..61191,66311..66400) |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS625.1 |    
Protein Information
| Protein ID | NP_001166289.1 |
|---|---|
| Protein Name | Phosphoglucomutase 1 |
| Molecular Wt. (Da) | 63660 |
| Protein Sequence |    Download   Select all |
| Length | 580   |
| Uniprot ID | P08123 |    
| Ensembl Protein ID | ENSP00000297268   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 117;- |
| T | Phosphorylation | 115 |
| K | Acetylation | 419 |
| K | Acetylation | 16 |
| K | Acetylation | 234 |
| S | Phosphorylation | 505 |
| T | Phosphorylation | 19 |
| T | Phosphorylation | 507 |
| Y | Phosphorylation | 353 |
| S | Phosphorylation | 369 |
Enzyme Information
| EC | 5.4.2.2 |    
|---|---|
| Name | phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) glucose phosphomutase phosphoglucose mutase |
| Class | Isomerases; Intramolecular transferases; Phosphotransferases (phosphomutases) |
| Sysname | alpha-D-glucose 1,6-phosphomutase   |
| Substrate | alpha-D-glucose 1-phosphate   |
| Product | D-glucose 6-phosphate   |
| Reaction (IUBMB) | ![]() |
PPi Information
No STRING Network could be found.
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Amino sugar and nucleotide sugar metabolism |    hsa00520 |    
| Galactose metabolism |    hsa00052 |    
| Glycolysis / Gluconeogenesis |    hsa00010 |    
| Metabolic pathways |    hsa01100 |    
| Pentose phosphate pathway |    hsa00030 |    
| Purine metabolism |    hsa00230 |    
| Starch and sucrose metabolism |    hsa00500 |    
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd03085 | 5-562  | PGM1 |
| cl03757 | 5-562  | phosphohexomutase superfamily |
| cd05800 | 18-507  | PGM_like2 |
| cd03084 | 110-422  | phosphohexomutase |
| pfam02878 | 14-158  | PGM_PMM_I |
| cl08375 | 14-158  | PGM_PMM_I superfamily |
| cd05799 | 18-507  | PGM2 |
| pfam02880 | 306-420  | PGM_PMM_III |
| cl17209 | 306-420  | PGM_PMM_III superfamily |
| cd03089 | 50-317  | PMM_PGM |
| cd05801 | 79-430  | PGM_like3 |
| cd05802 | 53-420  | GlmM |
| cd05803 | 20-358  | PGM_like4 |
| cd03087 | 52-527  | PGM_like1 |
| pfam02879 | 193-301  | PGM_PMM_II |
| cd03088 | 18-506  | ManB |
| pfam00408 | 487-537  | PGM_PMM_IV |
| cl02861 | 487-537  | PGM_PMM_IV superfamily |
| PLN02307 | 1-562  | PLN02307 |
| COG0033 | 4-545  | Pgm |
| PRK07564 | 4-542  | PRK07564 |
| COG1109 | 18-527  | ManB |
| TIGR03990 | 18-527  | Arch_GlmM |
| PTZ00150 | 18-430  | PTZ00150 |
| TIGR01132 | 18-429  | pgm |
| PRK14323 | 18-418  | glmM |
| TIGR01455 | 18-414  | glmM |
| PRK14324 | 57-414  | glmM |
| PRK14314 | 18-305  | glmM |
| PRK14316 | 92-293  | glmM |
| PRK10887 | 50-315  | glmM |
| PRK14317 | 92-295  | glmM |
| PRK14322 | 54-415  | glmM |
| PLN02371 | 78-315  | PLN02371 |
| PRK09542 | 54-315  | manB |
| PRK14315 | 58-414  | glmM |
| PRK14319 | 92-301  | glmM |
| PRK14318 | 58-403  | glmM |
| PRK14320 | 18-409  | glmM |
Ontology Information
| HPRD ID | 2363 |    
|---|---|
| Molecular Class | Enzyme: Mutase |
| Molecular Function | Extracellular matrix structural constituent (GO:0005201) |
| Biological Process | Cell growth and/or maintenance (GO:0008151)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    

