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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
PGM1 5236 Phosphoglucomutase 1  1CDG1T; GSD14 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
21531130   2011Cell line : -

Source : Japanees patients

Sample Type : CRC tumor and normal tissue

No. of Sample : 113 patients primary CRC

Stage : -

Peptide Nucleic Acid (PNA)-clamp real-timeRT-PCR TaqMan assay, Gene expression profiles Up-regulation--


Gene Details



Chromosome: 1; NC_000001.10 (64058947..64125916)

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Gene Type protein coding
Gene Family -
Description The protein encoded by this gene is an isozyme of phosphoglucomutase (PGM) and belongs to the phosphohexose mutase family. There are several PGM isozymes, which are encoded by different genes and catalyze the transfer of phosphate between the 1 and 6 positions of glucose. In most cell types, this PGM isozyme is predominant, representing about 90% of total PGM activity. In red cells, PGM2 is a major isozyme. This gene is highly polymorphic. Mutations in this gene cause glycogen storage disease type 14. Alternativley spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Mar 2010]  
Chromosome 1
Location 1p31
Start 63593276  
End 63660245  
Strand +  
Gene Sequence

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Length 66970  
OMIM ID 171900   
HGNC ID HGNC:8905   
Unigene ID Hs.1869    
Ensembl ID ENSG00000079739   
PharmGKB ID -   

mRNA Information


mRNA ID NM_002633.2
Exon join(1..459,36150..36312,36667..36813,38382..38507, 41554..41744,42959..43113,45410..45525,55242..55377, 58394..58577,61057..61191,66311..66970)  
mRNA Sequence

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Length 2487  



CDS Information


   
Location join(214..459,36150..36312,36667..36813,38382..38507, 41554..41744,42959..43113,45410..45525,55242..55377, 58394..58577,61057..61191,66311..66400)
CDS Sequence

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CCDS ID CCDS625.1



Protein Information


      
Protein IDNP_001166289.1
Protein NamePhosphoglucomutase 1
Molecular Wt. (Da)63660
Protein Sequence

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Length 580  
Uniprot IDP08123
Ensembl Protein ID ENSP00000297268  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation117;-
TPhosphorylation115
KAcetylation419
KAcetylation16
KAcetylation234
SPhosphorylation505
TPhosphorylation19
TPhosphorylation507
YPhosphorylation353
SPhosphorylation369

Enzyme Information


   
EC5.4.2.2
Namephosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)
glucose phosphomutase
phosphoglucose mutase
ClassIsomerases; Intramolecular transferases; Phosphotransferases (phosphomutases)
Sysnamealpha-D-glucose 1,6-phosphomutase  
Substratealpha-D-glucose 1-phosphate  
ProductD-glucose 6-phosphate  
Reaction (IUBMB)



PPi Information


No STRING Network could be found.

No matching records from HPRD source could be found.

Pathway Information


                                          
Pathway Name Pathway ID
Amino sugar and nucleotide sugar metabolism hsa00520
Galactose metabolism hsa00052
Glycolysis / Gluconeogenesis hsa00010
Metabolic pathways hsa01100
Pentose phosphate pathway hsa00030
Purine metabolism hsa00230
Starch and sucrose metabolism hsa00500


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd030855-562  PGM1
cl037575-562  phosphohexomutase superfamily
cd0580018-507  PGM_like2
cd03084110-422  phosphohexomutase
pfam0287814-158  PGM_PMM_I
cl0837514-158  PGM_PMM_I superfamily
cd0579918-507  PGM2
pfam02880306-420  PGM_PMM_III
cl17209306-420  PGM_PMM_III superfamily
cd0308950-317  PMM_PGM
cd0580179-430  PGM_like3
cd0580253-420  GlmM
cd0580320-358  PGM_like4
cd0308752-527  PGM_like1
pfam02879193-301  PGM_PMM_II
cd0308818-506  ManB
pfam00408487-537  PGM_PMM_IV
cl02861487-537  PGM_PMM_IV superfamily
PLN023071-562  PLN02307
COG00334-545  Pgm
PRK075644-542  PRK07564
COG110918-527  ManB
TIGR0399018-527  Arch_GlmM
PTZ0015018-430  PTZ00150
TIGR0113218-429  pgm
PRK1432318-418  glmM
TIGR0145518-414  glmM
PRK1432457-414  glmM
PRK1431418-305  glmM
PRK1431692-293  glmM
PRK1088750-315  glmM
PRK1431792-295  glmM
PRK1432254-415  glmM
PLN0237178-315  PLN02371
PRK0954254-315  manB
PRK1431558-414  glmM
PRK1431992-301  glmM
PRK1431858-403  glmM
PRK1432018-409  glmM


Ontology Information


   
HPRD ID2363
Molecular ClassEnzyme: Mutase
Molecular FunctionExtracellular matrix structural constituent (GO:0005201)
Biological ProcessCell growth and/or maintenance (GO:0008151)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO