Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| PHACTR3 | 116154 | phosphatase and actin regulator 3 | 20 | PPP1R123 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22135045 | 2012 | Cell line : - Source : - Sample Type : - No. of Sample : Cancer and matched normal tissue samples from 9 CRC, 34 normal colon mucosa tissue samples, 71 advanced adenomas, and 64 carcinomas. Stage : TNM Stage I-IV | Methylation specific PCR and real time RT-PCR | Hypermethylation | - | PHACTR3 is a new hypermethylated gene in CRC with a good performance in stool DNA testing and has complementary value to FIT. Phosphatase and Actin Regulator 3 (PHACTR3) was identified as a novel hypermethylated gene showing more than 70-fold increased DNA methylation levels in advanced neoplasia compared with normal colon mucosa. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Phosphatase and actin regulators |
| Description | This gene encodes a member of the phosphatase and actin regulator protein family. The encoded protein is associated with the nuclear scaffold in proliferating cells, and binds to actin and the catalytic subunit of protein phosphatase-1, suggesting that it functions as a regulatory subunit of protein phosphatase-1. Alternative splicing results in multiple transcript variants. | Chromosome | 20 |
| Location | 20q13.32-q |
| Start | 59577509 |
| End | 59847711 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 270203 |
| OMIM ID | 608725 |
| HGNC ID | HGNC:15833 |
| Unigene ID | Hs.473218 |
| Ensembl ID | ENSG00000087495 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_001199505.1 |
|---|---|
| Exon | join(1..109,165599..165760,170250..170327,177674..177856, 189678..189887,195771..195945,196735..196982, 228533..228686,258997..259052,262861..262922, 263887..264027,267681..267757,269607..270203) | mRNA Sequence | Download Select all |
| Length | 2275 |
CDS Information
| Location | join(1..109,165599..165760,170250..170327,177674..177856, 189678..189887,195771..195945,196735..196982, 228533..228686,258997..259052,262861..262922, 263887..264027,267681..267757,269607..269622) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS56202.1 |
Protein Information
| Protein ID | NP_001186434.1 |
|---|---|
| Protein Name | phosphatase and actin regulator 3 |
| Molecular Wt. (Da) | 62242 |
| Protein Sequence | Download Select all |
| Length | 556 |
| Uniprot ID | Q9Y4K0 |
| Ensembl Protein ID | ENSP00000373783 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 70 |
| T | Phosphorylation | 29 |
| T | Phosphorylation | 29 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam02755 | 440-464 | RPEL |
| cl23528 | 440-464 | RPEL superfamily |
| smart00707 | 440-464 | RPEL |
| cl23061 | 440-464 | RPEL superfamily |
| PTZ00121 | 292-551 | PTZ00121 |
Ontology Information
| HPRD ID | 1999 |
|---|---|
| Molecular Class | Regulatory/other subunit |
| Molecular Function | Lipase activity (GO:0016298) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091) |
Drug Information
No matching records could be found.