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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
PHLPP1 23239 PH domain and leucine rich repeat protein phosphatase 1  18KIAA0606, SCOP 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
23846336   2013Cell line : -

Source : -

Sample Type : CRC tumor and normal tissues

No. of Sample : 110

Stage : -

Real time PCR , Luciferase reporter assays Down-regulation--


Gene Details



NC_000018.9 (60382672..60647676)

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Gene Type protein coding
Gene Family Serine/threonine phosphatases / Protein phosphatases, Mg2+/Mn2+ dependent, "Pleckstrin homology (PH) domain containing"
Description This gene encodes a member of the serine/threonine phosphatase family. The encoded protein promotes apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling. [provided by RefSeq, Dec 2011]  
Chromosome 18
Location 18q21.32
Start 60382672  
End 60647676  
Strand +  
Gene Sequence

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Length 265005  
OMIM ID 609396   
HGNC ID HGNC:20610   
Unigene ID Hs.465337   
Ensembl ID ENSG00000081913   
PharmGKB ID PA165429055   

mRNA Information


mRNA ID ?NM_194449.3
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS45881.2



Protein Information


      
Protein IDNP_919431.2
Protein NamePH domain and leucine rich repeat protein phosphatase 1
Molecular Wt. (Da)0
Protein Sequence

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Length 1717  
Uniprot IDQ9NRW1
Ensembl Protein ID ENSP00000285208  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


      
Pathway Name Pathway ID
PI3K-Akt signaling pathway hsa04151


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd13322535-631  PH_PHLPP-like
cl17171535-631  PH-like superfamily
cd001431174-1422  PP2Cc
cl001201174-1422  PP2Cc superfamily
smart003321168-1420  PP2Cc
pfam004811174-1415  PP2C
COG06311197-1423  PTC1
cd00116625-929  LRR_RI
cl23707625-929  LRR_RI superfamily
cd00116814-1074  LRR_RI
cl23707814-1074  LRR_RI superfamily
cd00116777-1026  LRR_RI
cd00821539-629  PH
pfam00169556-636  PH
pfam12799737-778  LRR_4
cl19302737-778  LRR_4 superfamily
cd00116955-1139  LRR_RI
pfam127991014-1053  LRR_4
cl193021014-1053  LRR_4 superfamily
pfam127991036-1076  LRR_4
smart00233556-636  PH
pfam12799662-707  LRR_4
pfam12799987-1026  LRR_4
pfam13855962-1024  LRR_8
pfam13855896-952  LRR_8
pfam13855638-703  LRR_8
pfam138551036-1093  LRR_8
pfam13855691-772  LRR_8
PLN00113639-1126  PLN00113
COG4886940-1153  LRR
PRK15370901-1138  PRK15370
COG4886637-945  LRR
COG4886873-1139  LRR
PRK15370718-959  PRK15370
COG4886628-900  LRR
PLN031451282-1420  PLN03145
PTZ002241190-1423  PTZ00224
PRK15387832-1122  PRK15387
COG4886961-1156  LRR
PHA03247273-444  PHA03247
PHA03247272-462  PHA03247
PHA03247272-455  PHA03247
PLN03150685-776  PLN03150
PRK15387662-976  PRK15387
PLN00113873-1138  PLN00113
PHA03307272-456  PHA03307
PHA03307270-459  PHA03307
PTZ00449273-489  PTZ00449
PRK077642-444  PRK07764
PHA03247270-459  PHA03247
PHA03247273-459  PHA03247
PRK15387637-806  PRK15387
PHA03307266-456  PHA03307
PHA03247271-446  PHA03247
PHA03307270-428  PHA03307
PLN03150719-793  PLN03150
PRK12323261-440  PRK12323
PHA03378270-453  PHA03378
PHA0324753-421  PHA03247
PHA03381272-420  PHA03381
PRK07764292-464  PRK07764
PRK07003272-429  PRK07003
PHA03307270-442  PHA03307
pfam13855987-1048  LRR_8
pfam13855917-998  LRR_8
pfam03153273-417  TFIIA
PRK10905276-459  PRK10905
PRK07003287-465  PRK07003
PRK12323288-462  PRK12323
PHA03307272-465  PHA03307
PLN03210636-813  PLN03210
COG3456272-426  COG3456
PRK07764381-459  PRK07764
PRK14951270-397  PRK14951
PHA03378269-426  PHA03378
pfam12526312-416  DUF3729
PHA03307273-420  PHA03307
PHA03309271-452  PHA03309
PRK07764272-459  PRK07764
pfam03154275-426  Atrophin-1
PHA0324748-421  PHA03247


Ontology Information


   
HPRD ID6124
Molecular ClassUnclassified
Molecular FunctionTranscription regulator activity (GO:0030528)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO