Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| PIK3CA | 5290 | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha | 3 | PI3K |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24624362 | 2014 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | - | Mutation | - | PIK3CA mutations appear to be a promising predictive biomarker. Mutations in PIK3CA may be the long sought biomarker for successful adjuvant therapy with aspirin in patients with CRC. |
| 22039088 | 2012 | Cell line : - Source : - Sample Type : - No. of Sample : 576 mCRC patients Stage : TNM Stage IV | Meta-analysis | Mutation | - | PIK3CA exon 20 mutations may be a potential?biomarker?for resistance to anti-EGFR MoAbs in KRAS wild-type mCRC. |
| 22740953 | 2012 | Cell line : - Source : Tokyo Medical and Dental University Hospital Sample Type : - No. of Sample : 165 CRC patients. Stage : - | Direct sequencing method and real time RT- PCR | Mutation and methylation | - | Combination of genetic and epigenetic alterations is a potent biomarker for predicting the prognosis of CRC. Multivariate analysis revealed that the PIK3CA mutation and/or a high level of methylation predicts a poor DSS independently of clinicopathological characteristics. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | |
| Description | Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers. | Chromosome | 3 |
| Location | 3q26.3 |
| Start | 179148114 |
| End | 179240084 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 91971 |
| OMIM ID | 171834 |
| HGNC ID | HGNC:8975 |
| Unigene ID | Hs.553498 |
| Ensembl ID | ENSG00000121879 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | XM_006713658.2 |
|---|---|
| Exon | join(1..106,50637..51064,51577..51786,53177..53427, 55431..55676,56390..56475,61482..61587,62073..62225, 62318..62452,70097..70221,71083..71164,71458..71622, 71836..71939,72873..73044,75968..76074,76587..76708, 77849..77927,81159..81329,81891..82008,82112..82263, 85981..91971) | mRNA Sequence | Download Select all |
| Length | 3724 |
CDS Information
| Location | join(50713..51064,51577..51786,53177..53427,55431..55676, 56390..56475,61482..61587,62073..62225,62318..62452, 70097..70221,71083..71164,71458..71622,71836..71939, 72873..73044,75968..76074,76587..76708,77849..77927, 81159..81329,81891..82008,82112..82263,85981..86251) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS43171.1 |
Protein Information
| Protein ID | NP_006209.2 |
|---|---|
| Protein Name | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha |
| Molecular Wt. (Da) | 124154 |
| Protein Sequence | Download Select all |
| Length | 1068 |
| Uniprot ID | P20719 |
| Ensembl Protein ID | ENSP00000222726 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
| EC | 2.7.1.153 |
|---|---|
| Name | phosphatidylinositol-4,5-bisphosphate 3-kinase type I phosphoinositide 3-kinase |
| Class | Transferases; Transferring phosphorus-containing groups; Phosphotransferases with an alcohol group as acceptor |
| Sysname | ATP:1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 3-phosphotransferase |
| Substrate | ATP [CPD:C00002]; 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate |
| Product | ADP [CPD:C00008]; 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate |
| Reaction (IUBMB) |  |
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2904 | GRIN2B | 697 | NP_000825.2 | in vitro;in vivo | 10620012 |
| 3932 | LCK | 1080 | NP_005347.3 | in vitro | 8020561 |
| 4893 | NRAS | 1273 | NP_002515.1 | in vitro;in vivo | 78 205 498 665 852 |
| 6198 | RPS6KB1 | 10202 | NP_003152.1 | in vitro;in vivo | 11279232 |
| 8660 | IRS2 | 2878 | NP_003740.2 | in vitro;in vivo | 9113989 |
| 148022 | TICAM1 | 6350 | NP_891549.1 | in vivo | 15940673 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Acute myeloid leukemia | hsa05221 |
| Adrenergic signaling in cardiomyocytes | hsa04261 |
| AGE-RAGE signaling pathway in diabetic complications | hsa04933 |
| Aldosterone-regulated sodium reabsorption | hsa04960 |
| Amoebiasis | hsa05146 |
| AMPK signaling pathway | hsa04152 |
| Apoptosis | hsa04210 |
| B cell receptor signaling pathway | hsa04662 |
| Bacterial invasion of epithelial cells | hsa05100 |
| cAMP signaling pathway | hsa04024 |
| Carbohydrate digestion and absorption | hsa04973 |
| Central carbon metabolism in cancer | hsa05230 |
| cGMP-PKG signaling pathway | hsa04022 |
| Chagas disease (American trypanosomiasis) | hsa05142 |
| Chemokine signaling pathway | hsa04062 |
| Choline metabolism in cancer | hsa05231 |
| Cholinergic synapse | hsa04725 |
| Chronic myeloid leukemia | hsa05220 |
| Colorectal cancer | hsa05210 |
| Endometrial cancer | hsa05213 |
| Epstein-Barr virus infection | hsa05169 |
| ErbB signaling pathway | hsa04012 |
| Estrogen signaling pathway | hsa04915 |
| Fc epsilon RI signaling pathway | hsa04664 |
| Fc gamma R-mediated phagocytosis | hsa04666 |
| Focal adhesion | hsa04510 |
| FoxO signaling pathway | hsa04068 |
| Glioma | hsa05214 |
| Hepatitis B | hsa05161 |
| Hepatitis C | hsa05160 |
| HIF-1 signaling pathway | hsa04066 |
| HTLV-I infection | hsa05166 |
| Inflammatory mediator regulation of TRP channels | hsa04750 |
| Influenza A | hsa05164 |
| Inositol phosphate metabolism | hsa00562 |
| Insulin resistance | hsa04931 |
| Insulin signaling pathway | hsa04910 |
| Jak-STAT signaling pathway | hsa04630 |
| Leukocyte transendothelial migration | hsa04670 |
| Longevity regulating pathway - mammal | hsa04211 |
| Longevity regulating pathway - multiple species | hsa04213 |
| Measles | hsa05162 |
| Melanoma | hsa05218 |
| MicroRNAs in cancer | hsa05206 |
| mTOR signaling pathway | hsa04150 |
| Natural killer cell mediated cytotoxicity | hsa04650 |
| Neurotrophin signaling pathway | hsa04722 |
| Non-alcoholic fatty liver disease (NAFLD) | hsa04932 |
| Non-small cell lung cancer | hsa05223 |
| Osteoclast differentiation | hsa04380 |
| Oxytocin signaling pathway | hsa04921 |
| Pancreatic cancer | hsa05212 |
| Pathways in cancer | hsa05200 |
| Phosphatidylinositol signaling system | hsa04070 |
| Phospholipase D signaling pathway | hsa04072 |
| PI3K-Akt signaling pathway | hsa04151 |
| Platelet activation | hsa04611 |
| Progesterone-mediated oocyte maturation | hsa04914 |
| Prolactin signaling pathway | hsa04917 |
| Prostate cancer | hsa05215 |
| Proteoglycans in cancer | hsa05205 |
| Rap1 signaling pathway | hsa04015 |
| Ras signaling pathway | hsa04014 |
| Regulation of actin cytoskeleton | hsa04810 |
| Regulation of lipolysis in adipocytes | hsa04923 |
| Renal cell carcinoma | hsa05211 |
| Signaling pathways regulating pluripotency of stem cells | hsa04550 |
| Small cell lung cancer | hsa05222 |
| Sphingolipid signaling pathway | hsa04071 |
| T cell receptor signaling pathway | hsa04660 |
| Thyroid hormone signaling pathway | hsa04919 |
| TNF signaling pathway | hsa04668 |
| Toll-like receptor signaling pathway | hsa04620 |
| Toxoplasmosis | hsa05145 |
| Type II diabetes mellitus | hsa04930 |
| VEGF signaling pathway | hsa04370 |
| Viral carcinogenesis | hsa05203 |
Structure Information
| PDB ID | 2ENQ |
|---|---|
| Resolution | |
| Method | SOLUTION NMR |
| Chains | A |
| Molecule | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd05175 | 695-1064 | PI3Kc_IA_alpha |
| cl21453 | 695-1064 | PKc_like superfamily |
| cd08398 | 325-484 | C2_PI3K_class_I_alpha |
| cl14603 | 325-484 | C2 superfamily |
| cd00872 | 525-696 | PI3Ka_I |
| cl00271 | 525-696 | PI3Ka superfamily |
| cd05165 | 699-1064 | PI3Kc_I |
| cd00891 | 702-1046 | PI3Kc |
| cd05174 | 698-1064 | PI3Kc_IA_delta |
| cd05173 | 699-1064 | PI3Kc_IA_beta |
| cd05166 | 702-1064 | PI3Kc_II |
| cd00894 | 699-1062 | PI3Kc_IB_gamma |
| pfam00613 | 519-704 | PI3Ka |
| smart00145 | 521-704 | PI3Ka |
| cd05177 | 703-1064 | PI3Kc_C2_gamma |
| cd05176 | 705-1064 | PI3Kc_C2_alpha |
| smart00146 | 799-1017 | PI3Kc |
| cd00895 | 754-1064 | PI3Kc_C2_beta |
| cd00896 | 700-1046 | PI3Kc_III |
| pfam00454 | 799-1015 | PI3_PI4_kinase |
| cd00864 | 527-677 | PI3Ka |
| cd05167 | 800-1058 | PI4Kc_III_alpha |
| cd08380 | 325-484 | C2_PI3K_like |
| cd00893 | 796-1054 | PI4Kc_III |
| cd05168 | 799-1055 | PI4Kc_III_beta |
| cd00142 | 769-1007 | PI3Kc_like |
| cd08693 | 325-478 | C2_PI3K_class_I_beta_delta |
| pfam00792 | 350-484 | PI3K_C2 |
| cd00869 | 525-688 | PI3Ka_II |
| smart00143 | 31-108 | PI3K_p85B |
| cl02483 | 31-108 | PI3K_p85B superfamily |
| pfam02192 | 31-108 | PI3K_p85B |
| cd00870 | 520-676 | PI3Ka_III |
| smart00142 | 322-418 | PI3K_C2 |
| pfam00794 | 173-292 | PI3K_rbd |
| cl02484 | 173-292 | PI3K_rbd superfamily |
| smart00144 | 173-292 | PI3K_rbd |
| cd05172 | 800-961 | PIKKc_DNA-PK |
| cd05164 | 767-1006 | PIKKc |
| cd04012 | 352-487 | C2A_PI3K_class_II |
| cd08399 | 324-470 | C2_PI3K_class_I_gamma |
| cd00892 | 767-958 | PIKKc_ATR |
| cd05171 | 800-961 | PIKKc_ATM |
| cd05169 | 771-957 | PIKKc_TOR |
| cd00871 | 537-675 | PI4Ka |
| cd08397 | 354-447 | C2_PI3K_class_III |
| cd13968 | 789-935 | PKc_like |
| cd05170 | 897-960 | PIKKc_SMG1 |
| COG5032 | 799-1039 | TEL1 |
| PTZ00303 | 898-969 | PTZ00303 |
Ontology Information
| HPRD ID | 1813 |
|---|---|
| Molecular Class | Lipid Kinase |
| Molecular Function | GTPase activity (GO:0003924) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P42336 | DB00201 | Caffeine | SmallMoleculeDrug |