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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
PIK3R2 5296 phosphoinositide-3-kinase, regulatory subunit 2 (beta)  19P85B, p85 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
22733740   2012Cell line : -

Source : Tissue Bank Network Molecular Pathology Program of the Spanish National Cancer Center.

Sample Type : CRC tumor

No. of Sample : -

Stage : -

real time RT-PCR and Western BlottingUp-regulation-PIK3R2 encodes a ubiquitous regulatory subunit (p85?) of PI3K and p85? expression is elevated in breast and colon carcinomas and that its increased expression correlates with PI3K pathway activation and tumor progression.


Gene Details



NC_000019.9 (18263988..18281343)

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Gene Type protein coding
Gene Family SH2 domain containing
Description Phosphatidylinositol 3-kinase (PI3K) is a lipid kinase that phosphorylates phosphatidylinositol and similar compounds, creating second messengers important in growth signaling pathways. PI3K functions as a heterodimer of a regulatory and a catalytic subunit. The protein encoded by this gene is a regulatory component of PI3K. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2012]  
Chromosome 19
Location 19p13.11
Start 18263988  
End 18281343  
Strand +  
Gene Sequence

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Length 17356  
OMIM ID 603157   
HGNC ID HGNC:8980   
Unigene ID Hs.371344   
Ensembl ID ENSG00000105647   
PharmGKB ID PA33313   

mRNA Information


mRNA ID ?NM_005027.3
Exon join(1..117,2280..3024,7294..7386,7742..7792,7877..8008, 8102..8318,8789..8874,9025..9133,9231..9329,9790..9970, 10086..10211,12983..13125,13953..14129,15298..15369, 15549..15719,15910..17356)  
mRNA Sequence

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Length 3981  



CDS Information


   
Location 541..2727
CDS Sequence

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CCDS ID CCDS12371.1



Protein Information


      
Protein IDNP_005018.1
Protein Namephosphoinositide-3-kinase, regulatory subunit 2 (beta)
Molecular Wt. (Da)18112
Protein Sequence

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Length 728  
Uniprot IDQ9NPG1
Ensembl Protein ID ENSP00000240093  



Post-translational Modification Information (Source : HPRD)


Residue Type site
YPhosphorylation464;-
YPhosphorylation365;-
YPhosphorylation464;-
YPhosphorylation686;-
YPhosphorylation467;-
SPhosphorylation262
SPhosphorylation263
YPhosphorylation460
YPhosphorylation605
YPhosphorylation464
YPhosphorylation605
TPhosphorylation468
TPhosphorylation487

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                                                                              
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
558AXL171NP_068713.2in vitro;in vivo9178760   
867CBL1320NP_005179.2in vivo7629144   
1399CRKL3596NP_005198.1in vitro9092574   
1436CSF1R1269NP_005202.2in vivo1334406   
1950EGF578NP_001954.2in vivo1334406   
2064ERBB21281NP_004439.2in vivo1334406   
2534FYN655NP_002028.1in vivo1334406   
2885GRB2150NP_002077.1in vivo8662998   
3055HCK796NP_002101.2in vitro12029088   
3667IRS1943NP_005535.1in vivo;yeast 2-hybrid11   120   660   755   947   800   000   000   
3815KIT1287NP_000213.1in vitro;in vivo7537096   
47352-Sep3297NP_004395.1in vitro17024187   
5293PIK3CD4161AAB53966.1in vivo9113989   
6464SHC12780NP_001123512.1in vivo8662998   
6850SYK2514NP_003168.2yeast 2-hybrid15536084   
7046TGFBR11822NP_004603.1in vivo9435577   
8651SOCS14669NP_003736.1in vitro10022833   
30837SOCS712299NP_055413.1in vitro12052866   


Pathway Information


                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
Pathway Name Pathway ID
Acute myeloid leukemia hsa05221
Adrenergic signaling in cardiomyocytes hsa04261
AGE-RAGE signaling pathway in diabetic complications hsa04933
Aldosterone-regulated sodium reabsorption hsa04960
Amoebiasis hsa05146
AMPK signaling pathway hsa04152
Apoptosis hsa04210
B cell receptor signaling pathway hsa04662
Bacterial invasion of epithelial cells hsa05100
cAMP signaling pathway hsa04024
Carbohydrate digestion and absorption hsa04973
Central carbon metabolism in cancer hsa05230
cGMP-PKG signaling pathway hsa04022
Chagas disease (American trypanosomiasis) hsa05142
Chemokine signaling pathway hsa04062
Choline metabolism in cancer hsa05231
Cholinergic synapse hsa04725
Chronic myeloid leukemia hsa05220
Colorectal cancer hsa05210
Endometrial cancer hsa05213
Epstein-Barr virus infection hsa05169
ErbB signaling pathway hsa04012
Estrogen signaling pathway hsa04915
Fc epsilon RI signaling pathway hsa04664
Fc gamma R-mediated phagocytosis hsa04666
Focal adhesion hsa04510
FoxO signaling pathway hsa04068
Glioma hsa05214
Hepatitis B hsa05161
Hepatitis C hsa05160
HIF-1 signaling pathway hsa04066
HTLV-I infection hsa05166
Inflammatory mediator regulation of TRP channels hsa04750
Influenza A hsa05164
Insulin resistance hsa04931
Insulin signaling pathway hsa04910
Jak-STAT signaling pathway hsa04630
Leukocyte transendothelial migration hsa04670
Longevity regulating pathway - mammal hsa04211
Longevity regulating pathway - multiple species hsa04213
Measles hsa05162
Melanoma hsa05218
MicroRNAs in cancer hsa05206
mTOR signaling pathway hsa04150
Natural killer cell mediated cytotoxicity hsa04650
Neurotrophin signaling pathway hsa04722
Non-alcoholic fatty liver disease (NAFLD) hsa04932
Non-small cell lung cancer hsa05223
Osteoclast differentiation hsa04380
Oxytocin signaling pathway hsa04921
Pancreatic cancer hsa05212
Pathways in cancer hsa05200
Phosphatidylinositol signaling system hsa04070
Phospholipase D signaling pathway hsa04072
PI3K-Akt signaling pathway hsa04151
Platelet activation hsa04611
Progesterone-mediated oocyte maturation hsa04914
Prolactin signaling pathway hsa04917
Prostate cancer hsa05215
Proteoglycans in cancer hsa05205
Rap1 signaling pathway hsa04015
Ras signaling pathway hsa04014
Regulation of actin cytoskeleton hsa04810
Regulation of lipolysis in adipocytes hsa04923
Renal cell carcinoma hsa05211
Signaling pathways regulating pluripotency of stem cells hsa04550
Small cell lung cancer hsa05222
Sphingolipid signaling pathway hsa04071
T cell receptor signaling pathway hsa04660
Thyroid hormone signaling pathway hsa04919
TNF signaling pathway hsa04668
Toll-like receptor signaling pathway hsa04620
Toxoplasmosis hsa05145
Type II diabetes mellitus hsa04930
VEGF signaling pathway hsa04370
Viral carcinogenesis hsa05203


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd12926437-597  iSH2_PIK3R2
cl17108437-597  iSH2_PI3K_IA_R superfamily
cd09942322-432  SH2_nSH2_p85_like
cl15255322-432  SH2 superfamily
cd09930615-717  SH2_cSH2_p85_like
cl15255615-717  SH2 superfamily
cd11909Jul-80  SH3_PI3K_p85beta
cl17036Jul-80  SH3 superfamily
cd12925437-597  iSH2_PIK3R3
cd12924437-597  iSH2_PIK3R1
cd04388110-296  RhoGAP_p85
cl02570110-296  RhoGAP superfamily
cd12923437-596  iSH2_PI3K_IA_R
cd11776Jul-78  SH3_PI3K_p85
cd11910Jun-79  SH3_PI3K_p85alpha
smart00252329-410  SH2
smart00324122-251  RhoGAP
smart00252622-702  SH2
pfam00017622-696  SH2
pfam00017330-405  SH2
cd00173622-696  SH2
cd09940329-425  SH2_Vav_family
cd09930323-425  SH2_cSH2_p85_like
cd09942618-717  SH2_nSH2_p85_like
cd00173329-405  SH2
cd09940613-716  SH2_Vav_family
cd09923329-405  SH2_SOCS_family
cd10387330-404  SH2_SOCS6
pfam00620125-236  RhoGAP
cd09934324-426  SH2_Tec_family
cd09937330-427  SH2_csk_like
cd10407330-424  SH2_Vav3
cd09934622-716  SH2_Tec_family
cd09929324-425  SH2_BLNK_SLP-76
cd09935618-715  SH2_ABL
cd10383324-405  SH2_SOCS2
cd10399618-716  SH2_Tec_Bmx
cd09932617-716  SH2_C-SH2_PLC_gamma_like
cd10369618-715  SH2_Src_Frk
cd09933622-715  SH2_Src_family
cd10370618-715  SH2_Src_Src42
cd10388324-402  SH2_SOCS7
cd10361323-405  SH2_Fps_family
cd09933329-409  SH2_Src_family
cd09923622-696  SH2_SOCS_family
cd10407622-717  SH2_Vav3
cd10347622-696  SH2_Nterm_shark_like
cd10406330-426  SH2_Vav2
cd09943329-406  SH2_Nck_family
cd10397324-426  SH2_Tec_Btk
cd10718325-405  SH2_CIS
cd10398618-717  SH2_Tec_Txk
cd10397612-716  SH2_Tec_Btk
cd09941615-700  SH2_Grb2_like
cd10363618-715  SH2_Src_HCK
cd11780Sep-76  SH3_Sorbs_3
cd10352623-671  SH2_a2chimerin_b2chimerin
cd10344622-696  SH2_SLAP
cd10352323-402  SH2_a2chimerin_b2chimerin
cd10405330-424  SH2_Vav1
cd10365622-708  SH2_Src_Src
cd09935330-424  SH2_ABL
cd09929608-702  SH2_BLNK_SLP-76
cd10341329-410  SH2_N-SH2_PLC_gamma_like
cd09926330-370  SH2_CRK_like
cd10406622-717  SH2_Vav2
cd10384325-405  SH2_SOCS3
cd10355622-696  SH2_DAPP1_BAM32_like
cd10356619-693  SH2_ShkA_ShkC
cd09938622-715  SH2_N-SH2_Zap70_Syk_like
cd09941330-409  SH2_Grb2_like
cd09931622-716  SH2_C-SH2_SHP_like
cd10370330-409  SH2_Src_Src42
cd09937622-697  SH2_csk_like
cd10367622-715  SH2_Src_Fgr
cd09931330-406  SH2_C-SH2_SHP_like
cd11916Jul-78  SH3_Sorbs1_3
cd10405613-717  SH2_Vav1
cd10409329-406  SH2_Nck2
cd10365326-409  SH2_Src_Src
cd10396325-426  SH2_Tec_Itk
cd10399324-426  SH2_Tec_Bmx
cd11783Sep-75  SH3_SH3RF_3
cd09938330-409  SH2_N-SH2_Zap70_Syk_like
cd10382325-405  SH2_SOCS1
cd10360622-696  SH2_Srm
cd10344330-405  SH2_SLAP
cd10396622-716  SH2_Tec_Itk
cd10367326-405  SH2_Src_Fgr
cd09926621-670  SH2_CRK_like
cd09943622-699  SH2_Nck_family
cd10351328-408  SH2_SH2D4B
cd10362618-715  SH2_Src_Lck
cd10398324-425  SH2_Tec_Txk
cd10402617-676  SH2_C-SH2_Zap70
cd10418622-696  SH2_Src_Fyn_isoform_a_like
cd10354329-405  SH2_Cterm_RasGAP
cd11791Sep-77  SH3_UBASH3
cd10361617-697  SH2_Fps_family
cd10364329-409  SH2_Src_Lyn
cd10368622-696  SH2_Src_Fyn
cd00159125-236  RhoGAP
cd10418326-424  SH2_Src_Fyn_isoform_a_like
cd09946316-417  SH2_HSH2_like
cd10408329-406  SH2_Nck1
cd09946622-710  SH2_HSH2_like
cd10343622-716  SH2_SHIP
cd10357330-393  SH2_ShkD_ShkE
cd09932329-427  SH2_C-SH2_PLC_gamma_like
smart00326May-76  SH3
cd10347330-405  SH2_Nterm_shark_like
cd10368326-405  SH2_Src_Fyn
cd11918Sep-75  SH3_Vinexin_3
cd10348622-700  SH2_Cterm_shark_like
cd09927619-699  SH2_Tensin_like
cd04398122-251  RhoGAP_fRGD1
cd10401618-698  SH2_C-SH2_Syk_like
cd10408622-701  SH2_Nck1
cd10387622-695  SH2_SOCS6
cd10391620-716  SH2_SHE
cd09927330-370  SH2_Tensin_like
cd10341617-701  SH2_N-SH2_PLC_gamma_like
cd10391330-425  SH2_SHE
cd11823Aug-76  SH3_Nostrin
cd10337325-405  SH2_BCAR3
cd10343326-427  SH2_SHIP
cd11763Aug-76  SH3_SNX9_like
cd10419620-700  SH2_Src_Fyn_isoform_b_like
cd10364618-700  SH2_Src_Lyn
cd10388622-650  SH2_SOCS7
cd04379108-251  RhoGAP_SYD1
cd10392330-425  SH2_SHF
cd10356325-430  SH2_ShkA_ShkC
cd09945622-716  SH2_SHB_SHD_SHE_SHF_like
cd09925622-667  SH2_SHC
cd10417622-709  SH2_SH2D7
cd10369330-409  SH2_Src_Frk
cd10366622-699  SH2_Src_Yes
cd09944617-670  SH2_Grb7_family
cd09945330-425  SH2_SHB_SHD_SHE_SHF_like
cd10357620-650  SH2_ShkD_ShkE
cd10350622-679  SH2_SH2D4A
cd10337622-697  SH2_BCAR3
cd10358330-412  SH2_PTK6_Brk
cd10354622-696  SH2_Cterm_RasGAP
cd04387125-251  RhoGAP_Bcr
cd10348329-405  SH2_Cterm_shark_like
cd10380637-697  SH2_Jak3
cd09919617-672  SH2_STAT_family
cd10409622-708  SH2_Nck2
cd10402330-406  SH2_C-SH2_Zap70
cd10718618-650  SH2_CIS
cd10360330-370  SH2_Srm
cd04403126-251  RhoGAP_ARHGAP27_15_12_9
cd04385122-251  RhoGAP_ARAP
cd11917Jun-78  SH3_Sorbs2_3
cd10351622-677  SH2_SH2D4B
cd10353607-700  SH2_Nterm_RasGAP
cd09944330-382  SH2_Grb7_family
cd09925330-425  SH2_SHC
cd11789Aug-76  SH3_Nebulin_family_C
cd10384618-666  SH2_SOCS3
cd10355325-410  SH2_DAPP1_BAM32_like
cd11897Oct-76  SH3_SNX18
cd10366326-405  SH2_Src_Yes
cd10390622-716  SH2_SHD
cd11987Sep-76  SH3_Intersectin1_1
cd10346322-407  SH2_SH2B_family
cd10350328-424  SH2_SH2D4A
cd11926Sep-75  SH3_SH3RF1_3
cd10340330-425  SH2_N-SH2_SHP_like
cd11925Sep-75  SH3_SH3RF3_3
cd04373119-186  RhoGAP_p190
cd11785Aug-76  SH3_SH3RF_C
cd10412330-406  SH2_SH2B3
cd11836Sep-76  SH3_Intersectin_1
cd10349622-696  SH2_SH2D2A_SH2D7
cd10383622-652  SH2_SOCS2
cd11877Aug-76  SH3_PIX
cd11826Oct-76  SH3_Abi
cd1188123-75  SH3_MYO7A
cd04377125-233  RhoGAP_myosin_IX
cd10386623-651  SH2_SOCS5
cd10377331-373  SH2_STAT6
cd04382119-251  RhoGAP_MgcRacGAP
cd04408108-251  RhoGAP_GMIP
cd00174Aug-74  SH3
cd04393108-251  RhoGAP_FAM13A1a
TIGR02169454-648  SMC_prok_A
COG0419410-619  SbcC
COG1196451-633  Smc
COG1196425-611  Smc
TIGR02168397-605  SMC_prok_B
PRK12279446-610  PRK12279
COG1196427-576  Smc
TIGR02168409-572  SMC_prok_B
pfam09731463-613  Mitofilin
COG4487424-611  COG4487
TIGR04523401-611  Mplasa_alph_rch
COG1196410-578  Smc
pfam05010437-576  TACC
COG1322444-564  RmuC
TIGR00606456-577  rad50
PRK03918458-575  PRK03918
TIGR04523446-605  Mplasa_alph_rch
COG0419408-613  SbcC
pfam07111454-578  HCR
TIGR02168429-577  SMC_prok_B
pfam09311437-550  Rab5-bind
PRK11637429-549  PRK11637
TIGR02168444-572  SMC_prok_B
pfam14633598-651  SH2_2
COG4372428-572  COG4372
PRK01156435-594  PRK01156
pfam04156420-542  IncA


Ontology Information


   
HPRD ID258
Molecular ClassRegulatory/other subunit
Molecular FunctionTransporter activity (GO:0005215)
Biological ProcessTransport (GO:0006810)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
O00459DB01064IsoprenalineSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO