Search results:


General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
PIN1 5300 peptidylprolyl cis/trans isomerase, NIMA-interacting 1  19dod 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
16124054   2005Cell line : -

Source : -

Sample Type : CRC Tumor and normal tissue

No. of Sample : 124

Stage : 13Duke stage A, 47 Duke B, 56 Duke C and 8 Duke D

ImmunohistochemistryUp-regulation-Overexpression of Pin1 and beta-catenin may be closely related with the development and/or progression of colorectal carcinoma and further supports that Pin1 overexpression might contribute to the upregulation of beta-catenin.

16847925   2006Cell line : -

Source : -

Sample Type : CRC Tumor and normal tissue

No. of Sample : 105

Stage : -

ImmunohistochemistryUp-regulation-These results suggest that Pin1 plays an important role in colorectal tumorigenesis, presumably by increasing beta-catenin and cyclin D1 expressions.


Gene Details



NC_000019.9 (9945883..9960365)

View Larger Image
   
Gene Type protein coding
Gene Family -
Description Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. This gene encodes one of the PPIases, which specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. The conformational regulation catalyzed by this PPIase has a profound impact on key proteins involved in the regulation of cell growth, genotoxic and other stress responses, the immune response, induction and maintenance of pluripotency, germ cell development, neuronal differentiation, and survival. This enzyme also plays a key role in the pathogenesis of Alzheimer's disease and many cancers. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011]  
Chromosome 19
Location 19p13
Start 9945883  
End 9960365  
Strand +  
Gene Sequence

   Download   Select all

Length 14483  
OMIM ID 601052   
HGNC ID HGNC:8988   
Unigene ID Hs.465849   
Ensembl ID ENSG00000127445   
PharmGKB ID PA33320   

mRNA Information


mRNA ID ?NM_006221.3
Exon join(1..196,3230..3442,12824..12934,13884..14483)  
mRNA Sequence

   Download   Select all

Length 1138  



CDS Information


   
Location139..630
CDS Sequence

   Download   Select all

CCDS ID CCDS12220.1



Protein Information


      
Protein IDNP_006212.1
Protein Namepeptidylprolyl cis/trans isomerase, NIMA-interacting 1
Molecular Wt. (Da)30205
Protein Sequence

   Download   Select all

Length 163  
Uniprot IDP48307
Ensembl Protein ID ENSP00000222543  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation108
KAcetylation46
SPhosphorylation114
SPhosphorylation43

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
351APP100NP_000475.1in vivo16554819   
596BCL21045NP_000624.2in vivo11988841   
891CCNB1454NP_114172.1in vitro9499405   
898CCNE1455NP_001229.1in vitro16223725   
983CDK1302NP_001777.1in vivo11774038   
995CDC25C1146NP_001781.2in vitro;in vivo9   499   405   100   376   020   000   000   
996CDC27304NP_001107563.1in vitro949   940   510   037   602   
1457CSNK2A1277NP_001886.1in vitro;in vivo11940573   
1459CSNK2A2279NP_001887.1in vitro11940573   
1460CSNK2B278NP_001311.3in vitro;in vivo11940573   
1499CTNNB1286NP_001895.1in vitro;in vivo11533658   
3725JUN1302NP_002219.1in vitro;in vivo11432833   
4137MAPT1142NP_001116538.1in vitro;in vivo10391244   
4188MDFI7280NP_005577.1yeast 2-hybrid16189514   
4773NFATC22730NP_775114.1in vitro;in vivo11356192   
5770PTPN11477NP_002818.1in vitro9499405   
5867RAB4A1541NP_004569.2in vitro10888662   
5894RAF11265NP_002871.1in vitro;in vivo15664191   
5932RBBP84990AAH30590.1yeast 2-hybrid16189514   
6198RPS6KB110202NP_003152.1in vitro;in vivo19168580   
7153TOP2A536NP_001058.2in vitro11940573   
7157TP531859NP_000537.3in vitro;in vivo123   973   621   238   855   000   000   000   
7186TRAF23538NP_066961.2yeast 2-hybrid16189514   
7314UBB6771NP_061828.1in vivo16118204   
8733GPAA14334NP_003792.1yeast 2-hybrid16169070   
9021SOCS35006NP_003946.3yeast 2-hybrid16169070   
9650MTFR112389NP_055452.3yeast 2-hybrid16169070   
10743RAI17406NP_109590.3yeast 2-hybrid16189514   
10783NEK65348NP_001138473.1in vitro;in vivo16476580   
11030RBPMS11870NP_001008712.1yeast 2-hybrid16189514   
23062GGA29347NP_055859.1yeast 2-hybrid16189514   
27252KLHL2013918NP_055273.2yeast 2-hybrid16169070   
53635PTOV117929NP_059128.2yeast 2-hybrid16169070   
54819ZCCHC1015699NP_060135.1yeast 2-hybrid16169070   
56893UBQLN45670NP_064516.2yeast 2-hybrid16713569   
57062DDX245860NP_065147.1yeast 2-hybrid16169070   
79586CHPF10829NP_078812.2yeast 2-hybrid16169070   
81628TSC22D418231NP_112197.1yeast 2-hybrid16189514   
83637ZMIZ213225NP_113637.3yeast 2-hybrid16189514   


Pathway Information


      
Pathway Name Pathway ID
RIG-I-like receptor signaling pathway hsa04622


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd00201Aug-37  WW
cl00157Aug-37  WW superfamily
PTZ0035651-162  PTZ00356
cl0827851-162  Rotamase_2 superfamily
pfam0063959-163  Rotamase
pfam1361652-159  Rotamase_3
pfam00397Jul-37  WW
PRK1544182-159  PRK15441
smart00456Jul-39  WW
pfam1314594-163  Rotamase_2
COG076053-159  SurA
PRK0309554-163  prsA
PRK0299854-163  prsA
PRK0005952-159  prsA
TIGR0293323-160  nifM_nitrog
PRK03002103-163  prsA
PRK1077055-159  PRK10770
PRK0440561-159  prsA


Ontology Information


   
HPRD ID9064
Molecular ClassEnzyme: Isomerase
Molecular FunctionStructural constituent of cytoskeleton (GO:0005200)
Biological ProcessApoptosis (GO:0006915)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO