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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| PITX1 | 5307 | Paired-like homeodomain 1 | 5 | BFT; CCF; POTX; PTX1; LBNBG |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21531130 | 2011 | Cell line : - Source : Japanees patients Sample Type : CRC tumor and normal tissue No. of Sample : 113 CRC patients Stage : - | Peptide Nucleic Acid (PNA)-clamp real-time-PCR TaqMan assay, Gene expression profiles. | Up-regulation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Homeoboxes / PRD class |
| Description | This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Members of this family are involved in organ development and left-right asymmetry. This protein acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. [provided by RefSeq, Jul 2008] | Chromosome | 5 |
| Location | 5q31.1 |
| Start | 135027734 |
| End | 135034274 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 6541 |
| OMIM ID | 602149 |
| HGNC ID | HGNC:9004 |
| Unigene ID | Hs.84136 |
| Ensembl ID | ENSG00000069011 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_002653.4 |
|---|---|
| Exon | join(1..562,2767..2999,4954..6541) | mRNA Sequence | Download Select all |
| Length | 2383 |
CDS Information
| Location | join(394..562,2767..2999,4954..5496) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS4182.1 |
Protein Information
| Protein ID | NP_002644.4 |
|---|---|
| Protein Name | Paired-like homeodomain 1 |
| Molecular Wt. (Da) | 33997 |
| Protein Sequence | Download Select all |
| Length | 314 |
| Uniprot ID | P05997 |
| Ensembl Protein ID | ENSP00000364000 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 51;- |
| T | Phosphorylation | 53;- |
| S | Phosphorylation | 46;- |
| S | Phosphorylation | 48;- |
| S | Phosphorylation | 50;- |
| S | Phosphorylation | 314 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1958 | EGR1 | 549 | NP_001955.1 | in vitro | 10082522 |
| 2516 | NR5A1 | 1702 | NP_004950.2 | in vitro | 10369682 |
| 4760 | NEUROD1 | 3428 | NP_002491.2 | in vitro | 9343431 |
| 5449 | POU1F1 | 1409 | NP_001116229.1 | in vitro;yeast 2-hybrid | 8755540 |
| 11030 | RBPMS | 11870 | NP_001008712.1 | yeast 2-hybrid | 16189514 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00086 | 90-148 | homeodomain |
| cl00084 | 90-148 | homeodomain superfamily |
| pfam00046 | 90-146 | Homeobox |
| smart00389 | 89-145 | HOX |
| pfam03826 | 275-293 | OAR |
| cl08404 | 275-293 | OAR superfamily |
| pfam08430 | 203-274 | Fork_head_N |
| cl22540 | 203-274 | Fork_head_N superfamily |
| COG5576 | 36-146 | COG5576 |
Ontology Information
| HPRD ID | 284 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Acyltransferase activity (GO:0008415) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091) |
Drug Information
No matching records could be found.