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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| PKD2 | 5311 | polycystic kidney disease 2 (autosomal dominant) | 4 | PKD4, PC2, Pc-2, TRPP2 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24634417 | 2014 | Cell line : CCD 841 CoN, FHC, RKO Source : ATCC Sample Type : - No. of Sample : - Stage : - | Clonogenic assay,siRNA transfection,Western blotting ,real time RT-PCR, Flow cytometry | Up-regulation | - | PKD2 was the dominant isoform expressed in human colon cancer cells. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Voltage-gated ion channels / Transient receptor potential cation channels, "EF-hand domain containing" |
| Description | This gene encodes a member of the polycystin protein family. The encoded protein is a multi-pass membrane protein that functions as a calcium permeable cation channel, and is involved in calcium transport and calcium signaling in renal epithelial cells. This protein interacts with polycystin 1, and they may be partners in a common signaling cascade involved in tubular morphogenesis. Mutations in this gene are associated with autosomal dominant polycystic kidney disease type 2. [provided by RefSeq, Mar 2011] | Chromosome | 4 |
| Location | 4q22.1 |
| Start | 88928799 |
| End | 88998931 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 70133 |
| OMIM ID | 173910 |
| HGNC ID | HGNC:9009 |
| Unigene ID | Hs.181272 |
| Ensembl ID | ENSG00000118762 |
| PharmGKB ID | PA33343 |
mRNA Information
| mRNA ID | ?NM_000297.3 |
|---|---|
| Exon | join(7..690,11820..11933,28582..28715,30613..30863, 39004..39232,44353..44520,48448..48629,50345..50465, 54268..54366,57736..57857,58124..58241,60260..60423, 67174..67321,67820..70141) | mRNA Sequence | Download Select all |
| Length | 4856 |
Protein Information
| Protein ID | NP_000288.1 |
|---|---|
| Protein Name | polycystic kidney disease 2 (autosomal dominant) |
| Molecular Wt. (Da) | 423232 |
| Protein Sequence | Download Select all |
| Length | 968 |
| Uniprot ID | Q16204 |
| Ensembl Protein ID | ENSP00000263102 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 166;- |
| S | Phosphorylation | 254 |
| T | Phosphorylation | 260 |
| S | Phosphorylation | 263 |
| S | Phosphorylation | 852 |
| S | Phosphorylation | 949 |
| S | Phosphorylation | 812 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 88 | ACTN2 | 19 | NP_001094.1 | in vitro;in vivo;yeast 2-hybrid | 15843396 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00051 | 732-778 | EFh |
| cl08302 | 732-778 | EFh superfamily |
| pfam08016 | 267-687 | PKD_channel |
| PLN03223 | 388-769 | PLN03223 |
| pfam00520 | 478-680 | Ion_trans |
| TIGR00870 | 597-690 | trp |
Ontology Information
| HPRD ID | 2892 |
|---|---|
| Molecular Class | Membrane transport protein |
| Molecular Function | RNA binding (GO:0003723) |
| Biological Process | Regulation of translation (GO:0006445) |
Drug Information
No matching records could be found.