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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
PLA2G4A 5321 phospholipase A2, group IVA (cytosolic, calcium-dependent)  1cPLA2-alpha 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
25365190   2014Cell line : DLD 1, HT 29

Source : ATCC

Sample Type : -

No. of Sample : -

Stage : -

Ectopic expression and genetic silence of cPLA2?,Arachidonic acid release assay,MTS assay,Cell cycle analysis,BrdU incorporation,Immunoblotting,Immunohistochemistry.Down-regulation-cPLA2? is required for sustaining AKT phosphorylation at Ser473 and cell proliferation in CRC cells with PI3K mutation, and may serve as a potential therapeutic target for treatment of CRC resistant to anti-EGFR therapy.


Gene Details



NC_000001.10 (186798032..186958113)

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Gene Type protein coding
Gene Family -
Description This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]  
Chromosome 1
Location 1q25
Start 186798032  
End 186958113  
Strand +  
Gene Sequence

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Length 160082  
OMIM ID 600522   
HGNC ID HGNC:9035   
Unigene ID Hs.497200   
Ensembl ID ENSG00000116711   
PharmGKB ID PA271   

mRNA Information


mRNA ID ?NM_001311193.1
Exon join(1..136,25387..25488,41536..41617,64112..64260, 65199..65312,78066..78103,82349..82490,103864..104000, 110109..110331,111081..111195,117738..117875, 117970..118062,121758..121829,127203..127445, 136510..136694,148694..148889,150416..150573, 159478..160082)  
mRNA Sequence

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Length 2940  



CDS Information


   
Location206..2455
CDS Sequence

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CCDS ID CCDS1372.1



Protein Information


      
Protein IDNP_001298122.1
Protein Namephospholipase A2, group IVA (cytosolic, calcium-dependent)
Molecular Wt. (Da)0
Protein Sequence

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Length 749  
Uniprot IDP51114
Ensembl Protein ID ENSP00000307633  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation437
SPhosphorylation454
SPhosphorylation729
SPhosphorylation727
SPhosphorylation727
SPhosphorylation727
SPhosphorylation505
SPhosphorylation505
SPhosphorylation729;-
SPhosphorylation437;-
TPhosphorylation268;-
YPhosphorylation535;-
SPhosphorylation434;-
SPhosphorylation435;-
SPhosphorylation441;-
TPhosphorylation512;-
SPhosphorylation515;-
SPhosphorylation724
TPhosphorylation21
SPhosphorylation178
SPhosphorylation431
SPhosphorylation508

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                              
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
5322PLA2G53117NP_000920.1in vitro12124392   
7431VIM1899NP_003371.2in vitro10625659   


Pathway Information


                                                                                                                                    
Pathway Name Pathway ID
alpha-Linolenic acid metabolism hsa00592
Arachidonic acid metabolism hsa00590
Choline metabolism in cancer hsa05231
Ether lipid metabolism hsa00565
Fc epsilon RI signaling pathway hsa04664
Fc gamma R-mediated phagocytosis hsa04666
Glutamatergic synapse hsa04724
Glycerophospholipid metabolism hsa00564
GnRH signaling pathway hsa04912
Inflammatory mediator regulation of TRP channels hsa04750
Linoleic acid metabolism hsa00591
Long-term depression hsa04730
MAPK signaling pathway hsa04010
Metabolic pathways hsa01100
Ovarian steroidogenesis hsa04913
Oxytocin signaling pathway hsa04921
Phospholipase D signaling pathway hsa04072
Platelet activation hsa04611
Ras signaling pathway hsa04014
Serotonergic synapse hsa04726
Vascular smooth muscle contraction hsa04270
VEGF signaling pathway hsa04370


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd07200144-730  cPLA2_Grp-IVA
cl11396144-730  Patatin_and_cPLA2 superfamily
cd0403620-138  C2_cPLA2
cl1460320-138  C2 superfamily
pfam01735190-674  PLA2_B
cd00147144-714  cPLA2_like
cd07201143-721  cPLA2_Grp-IVB-IVD-IVE-IVF
cd07202142-645  cPLA2_Grp-IVC
cd01819192-417  Patatin_and_cPLA2
cd07203140-585  cPLA2_Fungal_PLB
smart0023919-120  C2
pfam0016821-106  C2
cd0003020-119  C2
cd0027535-115  C2_PLC_like
cd0027619-103  C2B_Synaptotagmin
cd0837843-121  C2B_MCTP_PRT_plant
cd0404422-111  C2A_Tricalbin-like
cd0403015-91  C2C_KIAA1228
cd0839141-111  C2A_C2C_Synaptotagmin_like
cd0403114-93  C2A_RIM1alpha
cd0837323-106  C2A_Ferlin
cd0402440-121  C2A_Synaptotagmin-like
cd0403822-107  C2_ArfGAP
cd0404043-120  C2D_Tricalbin-like
cd0405135-126  C2_SRC2_like
cd0404318-137  C2_Munc13_fungal
cd0869120-93  C2_NEDL1-like
cd0403537-118  C2A_Rabphilin_Doc2
cd0840521-93  C2B_Synaptotagmin-7
cd0402237-90  C2A_MCTP_PRT_plant
cd0403221-77  C2_Perforin
cd0405237-110  C2B_Tricalbin-like
cd0404120-118  C2A_fungal
cd0402117-112  C2_E3_ubiquitin_ligase
cd0402737-77  C2B_Munc13
cd0840219-93  C2B_Synaptotagmin-1
cd0402643-85  C2_PKC_alpha_gamma
cd0838537-77  C2A_Synaptotagmin-1-5-6-9-10
cd0404543-126  C2C_Tricalbin-like
cd0840417-93  C2B_Synaptotagmin-4
cd0838443-93  C2B_Rabphilin_Doc2
cd0852134-79  C2A_SLP
cd0402040-93  C2B_SLP_1-2-3-4
cd0403322-95  C2_NEDD4_NEDD4L
cd0838841-120  C2A_Synaptotagmin-4-11
cd0838616-77  C2A_Synaptotagmin-7
cd0838237-94  C2_Smurf-like
cd0401829-104  C2C_Ferlin
cd0837720-118  C2C_MCTP_PRT
cd0837642-111  C2B_MCTP_PRT
cd0404937-106  C2_putative_Elicitor-responsive_gene
cd0868840-112  C2_KIAA0528-like
cd0837543-118  C2_Intersectin
cd0840319-103  C2B_Synaptotagmin-3-5-6-9-10
cd0404241-120  C2A_MCTP_PRT
smart00022117-669  PLAc
COG503843-115  COG5038
COG503841-107  COG5038


Ontology Information


   
HPRD ID2827
Molecular ClassEnzyme: Phospholipase
Molecular FunctionTranscription factor activity (GO:0003700)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
P47712DB00041AldesleukinBiotechDrug
P47712DB00086StreptokinaseBiotechDrug
P47712DB00411CarbacholSmallMoleculeDrug
P47712DB00445EpirubicinSmallMoleculeDrug
P47712DB00578CarbenicillinSmallMoleculeDrug
P47712DB00591Fluocinolone AcetonideSmallMoleculeDrug
P47712DB01083OrlistatSmallMoleculeDrug
P47712DB04786SuraminSmallMoleculeDrug
P47712DB00588Fluticasone PropionateSmallMoleculeDrug
P47712DB01103QuinacrineSmallMoleculeDrug
P47712DB04552Niflumic AcidSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO