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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
PLCE1 51196 phospholipase C, epsilon 1  10KIAA1516, PLCE, NPHS3 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
26320491   2015Cell line : -

Source : University hospitals in Lithuania (Department of Gastroenterology and Department of Surgery; Lithuanian University of Health Sciences, Kaunas) and Latvia (Riga East University Hospital and Digestive Diseases Centre GASTRO, Riga).

Sample Type : CRC tumor and normal tissue

No. of Sample : -

Stage : TNM Stage I-IV

Genotyped by RT-PCRPolymorhpism-Gene polymorphisms of PSCA, PLCE1 and MUC1 genes are not associated with the presence of CRC in European subjects.


Gene Details



NC_000010.10 (95753746..96088149)

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Gene Type protein coding
Gene Family -
Description This gene encodes a phospholipase enzyme that catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate to generate two second messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). These second messengers subsequently regulate various processes affecting cell growth, differentiation, and gene expression. This enzyme is regulated by small monomeric GTPases of the Ras and Rho families and by heterotrimeric G proteins. In addition to its phospholipase C catalytic activity, this enzyme has an N-terminal domain with guanine nucleotide exchange (GEF) activity. Mutations in this gene cause early-onset nephrotic syndrome; characterized by proteinuria, edema, and diffuse mesangial sclerosis or focal and segmental glomerulosclerosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Sep 2009]  
Chromosome 10
Location 10q23
Start 95753746  
End 96088149  
Strand +  
Gene Sequence

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Length 334404  
OMIM ID 608414   
HGNC ID HGNC:17175   
Unigene ID Hs.655033   
Ensembl ID ENSG00000138193   
PharmGKB ID PA33391   

mRNA Information


mRNA ID ?NM_001165979.2
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS41552.1



Protein Information


      
Protein IDNP_001159451.1
Protein Namephospholipase C, epsilon 1
Molecular Wt. (Da)0
Protein Sequence

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Length 2302  
Uniprot IDQ9NR00
Ensembl Protein ID ENSP00000319914  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation490

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


                                                            
Pathway Name Pathway ID
AGE-RAGE signaling pathway in diabetic complications hsa04933
Calcium signaling pathway hsa04020
cAMP signaling pathway hsa04024
Inositol phosphate metabolism hsa00562
Metabolic pathways hsa01100
Phosphatidylinositol signaling system hsa04070
Proteoglycans in cancer hsa05205
Rap1 signaling pathway hsa04015
Ras signaling pathway hsa04014
Thyroid hormone signaling pathway hsa04919


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd085961391-1833  PI-PLCc_epsilon
cl146151391-1833  PI-PLCc_GDPD_SF superfamily
cd002751872-1984  C2_PLC_like
cl146031872-1984  C2 superfamily
cd085581396-1833  PI-PLCc_eukaryota
cd085931397-1833  PI-PLCc_delta
cd085911392-1833  PI-PLCc_beta
pfam003881394-1530  PI-PLC-X
cd085981394-1833  PI-PLC1c_yeast
cd085971397-1833  PI-PLCc_PRIP_metazoa
cd085921393-1833  PI-PLCc_gamma
smart001481397-1530  PLCXc
cd086301392-1833  PI-PLCc_delta3
cd086261392-1833  PI-PLCc_beta4
cd086271392-1530  PI-PLCc_gamma1
cd086331392-1833  PI-PLCc_eta2
cd086281391-1833  PI-PLCc_gamma2
cd086311392-1833  PI-PLCc_delta4
cd085941397-1576  PI-PLCc_eta
cd086321392-1833  PI-PLCc_eta1
cd086291392-1833  PI-PLCc_delta1
cd085951392-1833  PI-PLCc_zeta
cd086241392-1833  PI-PLCc_beta2
cd086251391-1833  PI-PLCc_beta3
pfam003871664-1845  PI-PLC-Y
cl147811664-1845  PI-PLC-Y superfamily
smart001491754-1845  PLCYc
cd086231392-1833  PI-PLCc_beta1
cd017802137-2236  PLC_epsilon_RA
cl001552137-2236  UBQ superfamily
cd085991397-1530  PI-PLCc_plant
cd001371397-1530  PI-PLCc
pfam00617532-713  RasGEF
cl02485532-713  RasGEF superfamily
smart00147531-824  RasGEF
cd085551405-1515  PI-PLCc_GDPD_SF
cd085941748-1833  PI-PLCc_eta
cd00155532-713  RasGEF
smart002391873-1968  C2
pfam007882138-2238  RA
pfam001681872-1945  C2
pfam092791328-1379  EF-hand_like
cl085381328-1379  EF-hand_like superfamily
cd017682138-2236  RA
cd000301872-1940  C2
smart003142136-2225  RA
cd085571395-1525  PI-PLCc_bacteria_like
cd040221875-1942  C2A_MCTP_PRT_plant
cd040391906-1941  C2_PSD
cd083851906-1940  C2A_Synaptotagmin-1-5-6-9-10
cd040191906-1961  C2C_MCTP_PRT_plant
cd084051907-1933  C2B_Synaptotagmin-7
cd040331901-1938  C2_NEDD4_NEDD4L
cd040261874-1942  C2_PKC_alpha_gamma
cd040431870-1946  C2_Munc13_fungal
cd040271869-1929  C2B_Munc13
PLN029521318-1983  PLN02952
PLN022281332-1983  PLN02228
PLN022221329-1970  PLN02222
PLN022301365-1970  PLN02230
PLN022231772-1968  PLN02223


Ontology Information


   
HPRD ID16507
Molecular ClassGuanine nucleotide exchange factor
Molecular FunctionTranscription factor activity (GO:0003700)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO