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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20089989 | 2010 | Cell line : - Source : VU University Medical Center, Amsterdam, The Netherlands. Sample Type : CRC tumor and normal tissue No. of Sample : - Stage : - | Biochemical isolation to nano-LC-MS/MS analysis | Up-regulation | - | This genes are differenitially expressed between colorectal adenoma and Colorectal cancer tissue. CRC tissue was collected at the VU University Medical Center, Amsterdam, The Netherlands. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene is a secreted blood zymogen that is activated by proteolysis and converted to plasmin and angiostatin. Plasmin dissolves fibrin in blood clots and is an important protease in many other cellular processes while angiostatin inhibits angiogenesis. Defects in this gene are likely a cause of thrombophilia and ligneous conjunctivitis. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Dec 2009] | Chromosome | 6 |
| Location | 6q26 |
| Start | 160702193 |
| End | 160754054 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 51862 |
| OMIM ID | 173350 |
| HGNC ID | HGNC:9071 |
| Unigene ID | Hs.143436 |
| Ensembl ID | ENSG00000122194 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_000301.3 |
|---|---|
| Exon | join(1..161,4215..4350,5508..5614,8885..8999,10794..10933, 12602..12722,14453..14571,16102..16264,16501..16646, 20216..20375,28859..29040,29553..29701,31803..31896, 34695..34815,36346..36420,36876..37016,39119..39225, 49923..50068,50708..51862) | mRNA Sequence | Download Select all |
| Length | 3538 |
CDS Information
| Location | join(113..161,4215..4350,5508..5614,8885..8999, 10794..10933,12602..12722,14453..14571,16102..16264, 16501..16646,20216..20375,28859..29040,29553..29701, 31803..31896,34695..34815,36346..36420,36876..37016, 39119..39225,49923..50068,50708..50869) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS5279.1 |
Protein Information
| Protein ID | NP_000292.1 |
|---|---|
| Protein Name | Plasminogen |
| Molecular Wt. (Da) | 88433 |
| Protein Sequence | Download Select all |
| Length | 810 |
| Uniprot ID | Q99612 |
| Ensembl Protein ID | ENSP00000419079 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Glycosylation | 268 |
| N | Glycosylation | 308 |
| T | Glycosylation | 365 |
| R | Proteolytic Cleavage | 549 |
| S | Phosphorylation | 597 |
| K | Proteolytic Cleavage | 634 |
| K | Proteolytic Cleavage | 670 |
| K | Proteolytic Cleavage | 680 |
| K | Proteolytic Cleavage | 717 |
| K | Proteolytic Cleavage | 727 |
| R | Proteolytic Cleavage | 580 |
| E | Proteolytic Cleavage | 458 |
| P | Proteolytic Cleavage | 466 |
| P | Proteolytic Cleavage | 466 |
| P | Proteolytic Cleavage | 563 |
| E | Proteolytic Cleavage | 78 |
| R | Proteolytic Cleavage | 580 |
| C | Disulfide Bridge | 188;316 |
| C | Disulfide Bridge | 481;560 |
| C | Disulfide Bridge | 502;543 |
| C | Disulfide Bridge | 531;555 |
| C | Disulfide Bridge | 585;577 |
| C | Disulfide Bridge | 685;567 |
| P | Proteolytic Cleavage | 465 |
| K | Proteolytic Cleavage | 96 |
| K | Proteolytic Cleavage | 96 |
| K | Proteolytic Cleavage | 96 |
| G | Proteolytic Cleavage | 19 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 302 | ANXA2 | 1061 | NP_001002858.1 | in vitro | 10077593 |
| 350 | APOH | 728 | NP_000033.2 | in vitro;in vivo | 95 966 648 460 120 |
| 462 | SERPINC1 | 122 | NP_000479.1 | in vitro | 10974350 |
| 506 | ATP5B | 44 | NP_001677.2 | in vitro | 10077593 |
| 1356 | CP | 317 | NP_000087.1 | in vitro;in vivo | 1 461 976 582 496 |
| 2023 | ENO1 | 1400 | NP_001419.1 | in vitro;in vivo | 11169399 |
| 2149 | F2R | 1763 | NP_001983.2 | in vitro | 10978167 |
| 2150 | F2RL1 | 2960 | NP_005233.3 | in vitro;in vivo | 12 604 689 109 781 600 000 000 |
| 2152 | F3 | 603 | NP_001984.1 | in vitro | 9490681 |
| 2920 | CXCL2 | 741 | NP_002080.1 | in vivo | 10928473 |
| 3146 | HMGB1 | 1228 | NP_002119.1 | in vitro | 1909331 |
| 3273 | HRG | 812 | NP_000403.1 | in vivo | 8478593 |
| 4224 | MEP1A | 2666 | NP_005579.2 | in vitro | 12189145 |
| 4314 | MMP3 | 1703 | NP_002413.1 | in vitro | 9548733 |
| 5118 | PCOLCE | 2603 | NP_002584.2 | in vitro | 10625689 |
| 5269 | SERPINB6 | 1413 | NP_004559.4 | in vitro | 7548163 |
| 6281 | S100A10 | 232 | NP_002957.1 | in vitro | 11939791 |
| 284217 | LAMA1 | 1033 | NP_005550.2 | in vitro | 8360181 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Complement and coagulation cascades | hsa04610 |
| Influenza A | hsa05164 |
| Neuroactive ligand-receptor interaction | hsa04080 |
| Staphylococcus aureus infection | hsa05150 |
Structure Information
| PDB ID | 1B2I |
|---|---|
| Resolution | - |
| Method | SOLUTION NMR |
| Chains | A |
| Molecule | PROTEIN (PLASMINOGEN) |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00190 | 581-804 | Tryp_SPc |
| cl21584 | 581-804 | Tryp_SPc superfamily |
| cd00108 | 102-182 | KR |
| cl00100 | 102-182 | KR superfamily |
| cd00108 | 272-353 | KR |
| cl00100 | 272-353 | KR superfamily |
| cd00108 | 182-262 | KR |
| cl00100 | 182-262 | KR superfamily |
| cd00108 | 478-561 | KR |
| cl00100 | 478-561 | KR superfamily |
| cd00108 | 375-455 | KR |
| cl00100 | 375-455 | KR superfamily |
| cd01099 | 38-97 | PAN_AP_HGF |
| cl00112 | 38-97 | PAN_APPLE superfamily |
| smart00130 | 101-183 | KR |
| smart00130 | 183-263 | KR |
| smart00130 | 273-354 | KR |
| pfam00051 | 275-352 | Kringle |
| smart00130 | 479-560 | KR |
| pfam00051 | 185-262 | Kringle |
| pfam00051 | 481-560 | Kringle |
| smart00130 | 375-456 | KR |
| pfam00051 | 103-181 | Kringle |
| pfam00051 | 377-454 | Kringle |
| smart00473 | 23-97 | PAN_AP |
| pfam00024 | 24-96 | PAN_1 |
| COG3591 | 586-629 | eMpr |
| smart00020 | 580-803 | Tryp_SPc |
| pfam00089 | 581-803 | Trypsin |
| COG5640 | 580-807 | COG5640 |
| pfam09342 | 592-703 | DUF1986 |
Ontology Information
| HPRD ID | 4218 |
|---|---|
| Molecular Class | Protease |
| Molecular Function | Cell adhesion molecule activity (GO:0005194) |
| Biological Process | Cell growth and/or maintenance (GO:0008151) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P00747 | DB00009 | Alteplase | BiotechDrug |
| P00747 | DB00013 | Urokinase | BiotechDrug |
| P00747 | DB00015 | Reteplase | BiotechDrug |
| P00747 | DB00029 | Anistreplase | BiotechDrug |
| P00747 | DB00031 | Tenecteplase | BiotechDrug |
| P00747 | DB00086 | Streptokinase | BiotechDrug |
| P00747 | DB00302 | Tranexamic Acid | SmallMoleculeDrug |
| P00747 | DB00513 | Aminocaproic Acid | SmallMoleculeDrug |
| P00747 | DB06692 | Aprotinin | BiotechDrug |