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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
PML 5371 promyelocytic leukemia  15MYL, TRIM19, RNF71 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
9748578   1998Cell line : -

Source : -

Sample Type : -

No. of Sample : -

Stage : Duke Stage D

Northern blotting,DDRT-PCR Down-regulation-Northern blot analysis showed that a 2.5 kb TIMP-3 transcript was expressed at a much higher level in normal tissue than the colorectal tumor.


Gene Details



NC_000015.9 (74287014..74340160)

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Gene Type protein coding
Gene Family Tripartite motif containing / Tripartite motif containing, "RING-type (C3HC4) zinc fingers"
Description The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]  
Chromosome 15
Location 15q24.1
Start 74287014  
End 74340160  
Strand +  
Gene Sequence

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Length 53147  
OMIM ID 102578   
HGNC ID HGNC:9113   
Unigene ID Hs.526464   
Ensembl ID ENSG00000140464   
PharmGKB ID PA33439   

mRNA Information


mRNA ID ?NM_002675.3
Exon join(1..269,3332..3804,28156..28736,30185..30255, 37900..38043,38484..38742,39806..39858,48317..48467, 49549..53147)  
mRNA Sequence

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Length 5600  



CDS Information


   
Location141..2789
CDS Sequence

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CCDS ID CCDS10255.1



Protein Information


      
Protein IDNP_002666.1
Protein Namepromyelocytic leukemia
Molecular Wt. (Da)84567
Protein Sequence

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Length 882  
Uniprot IDQ01650
Ensembl Protein ID ENSP00000261622  



Post-translational Modification Information (Source : HPRD)


Residue Type site
KSumoylation160
KSumoylation442
KSumoylation65
KSumoylation160
KSumoylation442
KSumoylation65
KSumoylation160
KSumoylation490
KSumoylation65
KSumoylation160
KSumoylation490
KSumoylation65
KSumoylation160
KSumoylation490
KSumoylation65
KSumoylation160
KSumoylation490
KSumoylation65
KSumoylation160
KSumoylation65
KSumoylation160
KSumoylation65
KSumoylation226
KSumoylation490
KSumoylation616
KSumoylation226
KSumoylation226
KSumoylation226
KSumoylation616
KSumoylation226
KSumoylation226
KSumoylation568
KSumoylation490
KSumoylation226
KSumoylation226
SPhosphorylation578;-
SPhosphorylation579;-
SPhosphorylation582;-
SPhosphorylation583;-
SPhosphorylation530;-
SPhosphorylation531;-
SPhosphorylation534;-
SPhosphorylation535;-
SPhosphorylation578;-
SPhosphorylation579;-
SPhosphorylation582;-
SPhosphorylation583;-
SPhosphorylation580;-
SPhosphorylation532;-
SPhosphorylation580;-
SPhosphorylation560;-
SPhosphorylation561;-
SPhosphorylation562;-
SPhosphorylation565;-
SPhosphorylation512;-
SPhosphorylation513;-
SPhosphorylation514;-
SPhosphorylation517;-
SPhosphorylation560;-
SPhosphorylation561;-
SPhosphorylation562;-
SPhosphorylation565;-
SPhosphorylation518;-
SPhosphorylation527;-
SPhosphorylation470;-
SPhosphorylation479;-
SPhosphorylation470;-
SPhosphorylation479;-
SPhosphorylation518;-
SPhosphorylation527;-
SPhosphorylation518;-
SPhosphorylation527;-
SPhosphorylation518;-
SPhosphorylation527;-
SPhosphorylation518;-
SPhosphorylation527;-
SPhosphorylation518;-
SPhosphorylation527;-
SPhosphorylation518;-
SPhosphorylation527;-
SPhosphorylation530;-
SPhosphorylation535;-
SPhosphorylation505;-
SPhosphorylation457;-
SPhosphorylation457;-
SPhosphorylation505;-
SPhosphorylation505;-
SPhosphorylation505;-
SPhosphorylation505;-
SPhosphorylation505;-
SPhosphorylation505;-
TPhosphorylation513;-
TPhosphorylation465;-
TPhosphorylation465;-
TPhosphorylation513;-
TPhosphorylation513;-
TPhosphorylation513;-
TPhosphorylation513;-
TPhosphorylation513;-
TPhosphorylation513;-
SPhosphorylation530;-
SPhosphorylation518;-
SPhosphorylation527;-
SPhosphorylation482;-
SPhosphorylation470;-
SPhosphorylation479;-
SPhosphorylation482;-
SPhosphorylation470;-
SPhosphorylation479;-
SPhosphorylation530;-
SPhosphorylation518;-
SPhosphorylation527;-
SPhosphorylation530;-
SPhosphorylation518;-
SPhosphorylation527;-
SPhosphorylation530;-
SPhosphorylation518;-
SPhosphorylation527;-
SPhosphorylation530;-
SPhosphorylation518;-
SPhosphorylation527;-
SPhosphorylation530;-
SPhosphorylation518;-
SPhosphorylation527;-
SPhosphorylation403;-
SPhosphorylation403;-
SPhosphorylation403;-
SPhosphorylation403;-
SPhosphorylation403;-
TPhosphorylation409
TPhosphorylation409
TPhosphorylation409
TPhosphorylation409
TPhosphorylation409
SPhosphorylation535
SPhosphorylation487
SPhosphorylation487
SPhosphorylation535
SPhosphorylation535
SPhosphorylation535
SPhosphorylation535
SPhosphorylation535
SPhosphorylation512
SPhosphorylation464
SPhosphorylation464
SPhosphorylation512
SPhosphorylation512
SPhosphorylation512
SPhosphorylation512
SPhosphorylation512
SPhosphorylation512
SPhosphorylation403
SPhosphorylation403
SPhosphorylation403
SPhosphorylation403
SPhosphorylation403
SPhosphorylation403
SPhosphorylation504
SPhosphorylation456
SPhosphorylation456
SPhosphorylation504
SPhosphorylation504
SPhosphorylation504
SPhosphorylation504
SPhosphorylation504
SPhosphorylation504
SPhosphorylation36
SPhosphorylation36
SPhosphorylation36
SPhosphorylation36
SPhosphorylation36
SPhosphorylation36
SPhosphorylation36
SPhosphorylation36
SPhosphorylation36
SPhosphorylation36
SPhosphorylation36
SPhosphorylation38
SPhosphorylation38
SPhosphorylation38
SPhosphorylation38
SPhosphorylation38
SPhosphorylation38
SPhosphorylation38
SPhosphorylation38
SPhosphorylation38
SPhosphorylation38
SPhosphorylation38
SPhosphorylation40
SPhosphorylation40
SPhosphorylation40
SPhosphorylation40
SPhosphorylation40
SPhosphorylation40
SPhosphorylation40
SPhosphorylation40
SPhosphorylation40
SPhosphorylation40
SPhosphorylation40
SPhosphorylation560
SPhosphorylation561
SPhosphorylation562
SPhosphorylation565
SPhosphorylation560
SPhosphorylation561
SPhosphorylation562
SPhosphorylation565
SPhosphorylation117
SPhosphorylation117
SPhosphorylation117
SPhosphorylation117
SPhosphorylation117
SPhosphorylation117
SPhosphorylation117
SPhosphorylation117
SPhosphorylation117
SPhosphorylation117
SPhosphorylation117
SPhosphorylation625

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                      
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
1457CSNK2A1277NP_001886.1in vitro16873060   
3066HDAC25521NP_001518.2in vitro11259576   
4088SMAD34380NP_005893.1in vivo15356634   
6612SUMO33754NP_008867.2in vitro15576338   
6790AURKA4066NP_003591.2in vivo15749021   
6839SUV39H12221NP_003164.1in vivo16449642   
8841HDAC38950NP_003874.2in vitro11259576   
9372ZFYVE94782NP_004790.2in vivo15356634   
22976PAXIP18491NP_031375.3in vitro;yeast 2-hybrid11940591   
140691TRIM6911518AAH47945.1in vitro;in vivo12837286   


Pathway Information


                                          
Pathway Name Pathway ID
Acute myeloid leukemia hsa05221
Endocytosis hsa04144
Herpes simplex infection hsa05168
Influenza A hsa05164
Pathways in cancer hsa05200
Transcriptional misregulation in cancer hsa05202
Ubiquitin mediated proteolysis hsa04120


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0016257-95  RING
cl1723857-95  RING superfamily
pfam0009757-91  zf-C3HC4
smart00479610-758  EXOIII
cl10012610-758  DnaQ_like_exo superfamily
smart00336124-166  BBOX
cl00034124-166  BBOX superfamily
smart0018457-91  RING
pfam00643126-166  zf-B_box
pfam1463456-93  zf-RING_5
pfam1392057-94  zf-C3HC4_3
pfam12126240-571  DUF3583
TIGR0059953-125  rad18
TIGR02169228-450  SMC_prok_A
pfam06008230-391  Laminin_I
COG543236-128  RAD18
COG4372233-332  COG4372
TIGR02168229-327  SMC_prok_B
PHA03307391-572  PHA03307
TIGR02169218-329  SMC_prok_A


Ontology Information


   
HPRD ID2077
Molecular ClassTranscription regulatory protein
Molecular FunctionChromatin binding (GO:0003682)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO