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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| POLR2L | 5441 | polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa | 11 | RPB10beta, RBP10, RPABC5, RPB7.6, hRPB7.6, hsRPB10b |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19368728 | 2009 | Cell line : HCT116, BxPC-3, A427, SKBr3 and LS174T Source : ATCC Sample Type : - No. of Sample : 56 Stage : - | real-time RT-PCR | Unknown | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | RNA polymerase subunits |
| Description | This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains four conserved cysteines characteristic of an atypical zinc-binding domain. Like its counterpart in yeast, this subunit may be shared by the other two DNA-directed RNA polymerases. [provided by RefSeq, Jul 2008] | Chromosome | 11 |
| Location | 11p15 |
| Start | 839721 |
| End | 842529 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 2809 |
| OMIM ID | 601189 |
| HGNC ID | HGNC:9199 |
| Unigene ID | Hs.441072 |
| Ensembl ID | ENSG00000177700 |
| PharmGKB ID | PA33519 |
mRNA Information
| mRNA ID | ?NM_021128.4 |
|---|---|
| Exon | join(1..116,2050..2809) | mRNA Sequence | Download Select all |
| Length | 925 |
Protein Information
| Protein ID | NP_066951.1 |
|---|---|
| Protein Name | polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa |
| Molecular Wt. (Da) | 198252 |
| Protein Sequence | Download Select all |
| Length | 67 |
| Uniprot ID | O15169 |
| Ensembl Protein ID | ENSP00000262320 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 4793 | NFKBIB | 7260 | NP_002494.2 | in vitro | 14743216 |
| 11007 | CCDC85B | 16101 | NP_006839.2 | yeast 2-hybrid | 16189514 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cytosolic DNA-sensing pathway | hsa04623 |
| Epstein-Barr virus infection | hsa05169 |
| Huntington's disease | hsa05016 |
| Metabolic pathways | hsa01100 |
| Purine metabolism | hsa00230 |
| Pyrimidine metabolism | hsa00240 |
| RNA polymerase | hsa03020 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| PLN00032 | Jan-67 | PLN00032 |
| cl00712 | Jan-67 | RNA_pol_N superfamily |
| pfam01194 | Jan-60 | RNA_pol_N |
| COG1644 | Jan-62 | RPB10 |
| PRK04016 | Jan-62 | PRK04016 |
Ontology Information
| HPRD ID | 4366 |
|---|---|
| Molecular Class | RNA polymerase |
| Molecular Function | Ubiquitin-specific protease activity (GO:0004843) |
| Biological Process | Protein metabolism (GO:0019538) |
Drug Information
No matching records could be found.