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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23581414 | 2013 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | - | Down-regulation | - | PON1 and ARE activities were significantly lower in patients with CRC compared to controls. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Paraoxonases |
| Description | The enzyme encoded by this gene is an arylesterase that mainly hydrolyzes paroxon to produce p-nitrophenol. Paroxon is an organophosphorus anticholinesterase compound that is produced in vivo by oxidation of the insecticide parathion. Polymorphisms in this gene are a risk factor in coronary artery disease. The gene is found in a cluster of three related paraoxonase genes at 7q21.3. [provided by RefSeq, Oct 2008] | Chromosome | 7 |
| Location | 7q21.3 |
| Start | 94927669 |
| End | 94953884 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 26216 |
| OMIM ID | 168820 |
| HGNC ID | HGNC:9204 |
| Unigene ID | Hs.370995 |
| Ensembl ID | ENSG00000005421 |
| PharmGKB ID | PA33529 |
mRNA Information
| mRNA ID | ?NM_000446.5 |
|---|---|
| Exon | complement(9247..>9282) | mRNA Sequence | Download Select all |
| Length | 5444 |
Protein Information
| Protein ID | NP_000437.3 |
|---|---|
| Protein Name | paraoxonase 1 |
| Molecular Wt. (Da) | 49773 |
| Protein Sequence | Download Select all |
| Length | 355 |
| Uniprot ID | Q9Y2T1 |
| Ensembl Protein ID | ENSP00000302625 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| N | Glycosylation | 253 |
| N | Glycosylation | 324 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 213 | ALB | 62 | NP_000468.1 | in vitro | 6324579 |
| 335 | APOA1 | 2517 | NP_000030.1 | in vitro | 16128586 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Metabolic pathways | hsa01100 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam01731 | 168-253 | Arylesterase |
| cl22863 | 168-253 | Str_synth superfamily |
| pfam03088 | 169-248 | Str_synth |
| cd14962 | 205-250 | NHL_like_6 |
| cl18310 | 205-250 | NHL superfamily |
| COG3386 | 92-295 | YvrE |
| pfam08450 | 205-307 | SGL |
Ontology Information
| HPRD ID | 10345 |
|---|---|
| Molecular Class | Enzyme: Esterase |
| Molecular Function | Protein serine/threonine kinase activity (GO:0004674) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P27169 | DB01327 | Cefazolin | SmallMoleculeDrug |