Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| POT1 | 25913 | protection of telomeres 1 | 7 | hPot1, DKFZp586D211 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25194444 | 2014 | Cell line : - Source : Gu�lhane Millitary Medical Academy (GATA) in Turkey. Sample Type : CRC tumor and adjacent normal tissues No. of Sample : 20 Stage : TNM Stage I-IV | TRAP silver staining assay,real time RT-PCR | Unknown | 3.4 fold | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene is a member of the telombin family and encodes a nuclear protein involved in telomere maintenance. Specifically, this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation. Increased transcriptional expression of this gene is associated with stomach carcinogenesis and its progression. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008] | Chromosome | 7 |
| Location | 7q31.33 |
| Start | 124462440 |
| End | 124570037 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 107598 |
| OMIM ID | 606478 |
| HGNC ID | HGNC:17284 |
| Unigene ID | Hs.31968 |
| Ensembl ID | ENSG00000128513 |
| PharmGKB ID | PA134934904 |
Protein Information
| Protein ID | NP_001036059.1 |
|---|---|
| Protein Name | protection of telomeres 1 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 634 |
| Uniprot ID | Q6BDS2 |
| Ensembl Protein ID | ENSP00000192788 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 7013 | TERF1 | 2975 | NP_059523.2 | in vitro;in vivo | 12768206 |
| 8658 | TNKS | 4490 | NP_003738.2 | in vitro;in vivo | 12768206 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd04498 | 161-278 | hPOT1_OB2 |
| cl09930 | 161-278 | RPA_2b-aaRSs_OBF_like superfamily |
| cd04497 | 9-141 | hPOT1_OB1_like |
| cl09930 | 9-141 | RPA_2b-aaRSs_OBF_like superfamily |
| smart00976 | 11-141 | Telo_bind |
| pfam02765 | 9-141 | POT1 |
| cd03524 | 24-99 | RPA2_OBF_family |
Ontology Information
| HPRD ID | 7901 |
|---|---|
| Molecular Class | DNA binding protein |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Biological_process unknown (GO:0000004) |
Drug Information
No matching records could be found.