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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
PPARG 5468 Peroxisome proliferator-activated receptor gamma  3GLM1; CIMT1; NR1C3; PPARG1; PPARG2; PPARgamma 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
22991505   2012Cell line : -

Source : -

Sample Type : -

No. of Sample : -

Stage : -

-Down-regulation--


Gene Details



Chromosome: 3; NC_000003.11 (12329349..12475855)

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Gene Type protein coding
Gene Family Nuclear hormone receptors
Description This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008]  
Chromosome 3
Location 3p25
Start 12287850  
End 12471013  
Strand +  
Gene Sequence

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Length 183164  
OMIM ID 601487   
HGNC ID HGNC:9236   
Unigene ID Hs.162646    
Ensembl ID ENSG00000132170   
PharmGKB ID PA281   

mRNA Information


mRNA ID NM_138712.3
Exon join(1..171,24531..24604,91855..92082,93473..93642, 104765..104903,118033..118232,128855..129305, 146049..146507)  
mRNA Sequence

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Length 1892  



CDS Information


   
Location join(63744..63825,91855..92082,93473..93642, 104765..104903,118033..118232,128855..129305, 182972..183039)
CDS Sequence

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CCDS ID -



Protein Information


      
Protein IDNP_005028.4
Protein NamePeroxisome proliferator-activated receptor gamma
Molecular Wt. (Da)54550
Protein Sequence

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Length 477  
Uniprot IDO95471
Ensembl Protein ID ENSP00000353475  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation112
SPhosphorylation84
SPhosphorylation84
SPhosphorylation84
SPhosphorylation112
SPhosphorylation84
SPhosphorylation84
SPhosphorylation84
TPhosphorylation269
TPhosphorylation241
TPhosphorylation241
TPhosphorylation241

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                      
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
547KIF1A3156NP_004312.2yeast 2-hybrid15604093   
2168FABP1612NP_001434.1yeast 2-hybrid11226238   
2308FOXO1645NP_002006.2in vitro;yeast 2-hybrid12966085   
4780NFE2L22732NP_006155.2in vitro10930400   
6256RXRA1577NP_002948.1in vitro;yeast 2-hybrid783   871   510   854   698   000   000   000   000   000   000   000   000   
6258RXRG1579NP_008848.1in vivo12615696   
8648NCOA14070NP_003734.3in vitro;yeast 2-hybrid904   112   410   848   596   
10048RANBP94835NP_005484.2yeast 2-hybrid15604093   
10987COPS56888NP_006828.2yeast 2-hybrid15604093   
85441-11459NP_001032412.2in vitro;yeast 2-hybrid16239304   


Pathway Information


                                                
Pathway Name Pathway ID
AMPK signaling pathway hsa04152
Huntington's disease hsa05016
Longevity regulating pathway - mammal hsa04211
Osteoclast differentiation hsa04380
Pathways in cancer hsa05200
PPAR signaling pathway hsa03320
Thyroid cancer hsa05216
Transcriptional misregulation in cancer hsa05202


Structure Information


PDB ID1FM6
Resolution2.1
MethodX-RAY DIFFRACTION
Chains A,U  
Molecule RETINOIC ACID RECEPTOR RXR-ALPHA  
Model View



Domain Information




ID Location Description
cd06932237-504  NR_LBD_PPAR
cl11397237-504  NR_LBD superfamily
cd06965138-221  NR_DBD_Ppar
cl02596138-221  NR_DBD_like superfamily
cd06929309-481  NR_LBD_F1
cd07158139-209  NR_DBD_Ppar_like
cd06916139-209  NR_DBD_like
cd07166134-220  NR_DBD_REV_ERB
pfam00105137-205  zf-C4
cd07165139-218  NR_DBD_DmE78_like
pfam1257731-108  PPARgamma_N
cl1395231-108  PPARgamma_N superfamily
smart00399139-203  ZnF_C4
cd06941319-501  NR_LBD_DmE78_like
cd06157311-473  NR_LBD
cd06968137-225  NR_DBD_ROR
cd06961138-221  NR_DBD_TR
cd06940320-485  NR_LBD_REV_ERB
cd06960139-212  NR_DBD_HNF4A
cd07169139-214  NR_DBD_GCNF_like
cd06964139-212  NR_DBD_RAR
cd07168139-214  NR_DBD_DHR4_like
cd07167139-213  NR_DBD_Lrh-1_like
cd06969139-209  NR_DBD_NGFI-B
cd06967139-214  NR_DBD_TR2_like
cd06956139-209  NR_DBD_RXR
cd07179139-211  2DBD_NR_DBD2
cd06954293-501  NR_LBD_LXR
cd06939299-505  NR_LBD_ROR_like
cd07164139-214  NR_DBD_PNR_like_1
cd07154139-209  NR_DBD_PNR_like
cd06970139-215  NR_DBD_PNR
cd06958139-209  NR_DBD_COUP_TF
cd07156139-203  NR_DBD_VDR_like
cd06935320-500  NR_LBD_TR
cd07163131-215  NR_DBD_TLX
cd06937317-500  NR_LBD_RAR
pfam00104326-485  Hormone_recep
cd07155139-212  NR_DBD_ER_like
cd07171139-212  NR_DBD_ER
cd06957139-218  NR_DBD_PNR_like_2
cd07170139-213  NR_DBD_ERR
cd06959139-203  NR_DBD_EcR_like
cd07161139-203  NR_DBD_EcR
smart00430324-473  HOLI
cd06933320-503  NR_LBD_VDR
cd07162139-225  NR_DBD_PXR
cd06955139-228  NR_DBD_VDR
cd07157139-212  2DBD_NR_DBD1
cd07160139-203  NR_DBD_LXR
cd06936317-499  NR_LBD_Fxr
cd06962139-203  NR_DBD_FXR
cd06966139-203  NR_DBD_CAR
cd06938293-501  NR_LBD_EcR
cd06943323-473  NR_LBD_RXR_like
cd06942320-496  NR_LBD_Sex_1_like
cd06930328-473  NR_LBD_F2
cd06934321-500  NR_LBD_PXR_like
cd07172139-203  NR_DBD_GR_PR
cd07173139-204  NR_DBD_AR
cd06963139-210  NR_DBD_GR_like
cd07348279-503  NR_LBD_NGFI-B
cd06931326-500  NR_LBD_HNF4_like
cd06948326-473  NR_LBD_COUP-TF
cd07068327-500  NR_LBD_ER_like
cd07071324-485  NR_LBD_Nurr1
cd06945321-504  NR_LBD_Nurr1_like
cd07072314-484  NR_LBD_DHR38_like
cd06952327-471  NR_LBD_TR2_like
cd07069324-473  NR_LBD_Lrh-1
cd06946319-500  NR_LBD_ERR
cd06953319-483  NR_LBD_DHR4_like
cd06944324-473  NR_LBD_Ftz-F1_like
cd06949327-500  NR_LBD_ER
cd06947324-348  NR_LBD_GR_Like
cd07074324-348  NR_LBD_PR
cd07076326-348  NR_LBD_GR
cd06951301-478  NR_LBD_Dax1_like


Ontology Information


   
HPRD ID1267
Molecular ClassNuclear receptor
Molecular FunctionReceptor signaling complex scaffold activity (GO:0030159)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
P37231DB00159IcosapentSmallMoleculeDrug
P37231DB00244MesalazineSmallMoleculeDrug
P37231DB00328IndomethacinSmallMoleculeDrug
P37231DB00412RosiglitazoneSmallMoleculeDrug
P37231DB00731NateglinideSmallMoleculeDrug
P37231DB00795SulfasalazineSmallMoleculeDrug
P37231DB00912RepaglinideSmallMoleculeDrug
P37231DB00966TelmisartanSmallMoleculeDrug
P37231DB01014BalsalazideSmallMoleculeDrug
P37231DB01050IbuprofenSmallMoleculeDrug
P37231DB01067GlipizideSmallMoleculeDrug
P37231DB01132PioglitazoneSmallMoleculeDrug
P37231DB01252MitiglinideSmallMoleculeDrug
P37231DB01393BezafibrateSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO