Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| PPP1R3C | 5507 | protein phosphatase 1, regulatory subunit 3C | 10 | PTG |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24861485 | 2014 | Cell line : - Source : Department of Digestive Surgery, Graduate School of Medicine, Nihon University.� Sample Type : Peripheral blood No. of Sample : 120 patients undergoing surgical operations for CRC (CRC group).Corresponding primary CRC tissue samples were also collected from 24 CRC patients. Stage : TNM Stage I-IV. | Methylation-specific PCR,Pyrosequencing analysis. | Methylation | - | PPP1R3C methylation or its combined use of EFHD1 methylation was highly positive in CRC plasma samples, and they might be useful in detection of CRC, especially for early-stage CRCs. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits |
| Description | This gene encodes a regulatory subunit of protein phosphatase-1 (PP1). PP1 catalyzes reversible protein phosphorylation, which is important in a wide range of cellular activities: neuronal, muscular, RNA splicing, protein synthesis, cell death, and glycogen metabolism, to name just a few. By interacting with different regulatory subunits, PP1 is directed to different parts of the cell, to different substrates, or to respond to extracellular signals. [provided by RefSeq, Oct 2011] | Chromosome | 10 |
| Location | 10q23-q24 |
| Start | 93388197 |
| End | 93392858 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 4662 |
| OMIM ID | 602999 |
| HGNC ID | HGNC:9293 |
| Unigene ID | Hs.303090 |
| Ensembl ID | ENSG00000119938 |
| PharmGKB ID | PA33653 |
mRNA Information
| mRNA ID | ?NM_005398.5 |
|---|---|
| Exon | join(1..146,2236..4662) | mRNA Sequence | Download Select all |
| Length | 2576 |
Protein Information
| Protein ID | NP_005389.1 |
|---|---|
| Protein Name | protein phosphatase 1, regulatory subunit 3C |
| Molecular Wt. (Da) | 103785 |
| Protein Sequence | Download Select all |
| Length | 317 |
| Uniprot ID | O00311 |
| Ensembl Protein ID | ENSP00000234626 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Insulin resistance | hsa04931 |
| Insulin signaling pathway | hsa04910 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam03370 | 153-256 | CBM_21 |
| cl08388 | 153-256 | CBM_21 superfamily |
| pfam03423 | 172-256 | CBM_25 |
| cl04060 | 172-256 | CBM_25 superfamily |
Ontology Information
| HPRD ID | 5203 |
|---|---|
| Molecular Class | Regulatory/other subunit |
| Molecular Function | G-protein coupled receptor activity (GO:0004930) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.