Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| PPP2R2A | 5520 | protein phosphatase 2, regulatory subunit B, alpha | 8 | PR52A, PR55A, B55A |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 26054685 | 2015 | Cell line : SW620, COLO205, COLO320DM, SW480, KM202L, HT-29, SW403, FHC Source : National Rodent Laboratory Animal Resource (Shanghai, People�s Republic of China). Guangzhou First People�s Hospital, Guangzhou Medical University (Guangzhou, People�s Republic of China). Sample Type : CRC tumor and normal tissue No. of Sample : 8 Stage : - | luciferase reporter assays,real-time quantitative PCR,Western blotting,transfection. | Down-regulation | - | Overexpression of miR-892a may provide a selective growth promotion for CRC cells by direct suppression of PPP2R2A expression. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Serine/threonine phosphatases / Protein phosphatase 2, regulatory subunits, "WD repeat domain containing" |
| Description | The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010] | Chromosome | 8 |
| Location | 8p21.2 |
| Start | 26149007 |
| End | 26230196 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 81190 |
| OMIM ID | 604941 |
| HGNC ID | HGNC:9304 |
| Unigene ID | Hs.146339 |
| Ensembl ID | ENSG00000221914 |
| PharmGKB ID | PA33668 |
mRNA Information
| mRNA ID | ?NM_001177591.1 |
|---|---|
| Exon | join(1..336,2176..2250,47400..47497,62978..63143, 68679..68791,69484..69661,71194..71358,72231..72400, 74825..74916,78644..81190) | mRNA Sequence | Download Select all |
| Length | 3945 |
Protein Information
| Protein ID | NP_001171062.1 |
|---|---|
| Protein Name | protein phosphatase 2, regulatory subunit B, alpha |
| Molecular Wt. (Da) | 62189 |
| Protein Sequence | Download Select all |
| Length | 447 |
| Uniprot ID | Q9ULV1 |
| Ensembl Protein ID | ENSP00000434034 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 167 |
| T | Phosphorylation | 378 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2906 | GRIN2D | 4095 | NP_000827.2 | in vivo | 10862698 |
| 5515 | PPP2CA | 8912 | NP_002706.1 | in vitro | 1328247 |
| 5519 | PPP2R1B | 4384 | NP_859050.1 | in vitro;in vivo | 132 824 717 540 176 |
| 7046 | TGFBR1 | 1822 | NP_004603.1 | in vitro;in vivo | 9774674 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Adrenergic signaling in cardiomyocytes | hsa04261 |
| AMPK signaling pathway | hsa04152 |
| Chagas disease (American trypanosomiasis) | hsa05142 |
| Dopaminergic synapse | hsa04728 |
| Hepatitis C | hsa05160 |
| Hippo signaling pathway | hsa04390 |
| mRNA surveillance pathway | hsa03015 |
| PI3K-Akt signaling pathway | hsa04151 |
| Sphingolipid signaling pathway | hsa04071 |
| Tight junction | hsa04530 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00200 | 29-370 | WD40 |
| cl02567 | 29-370 | WD40 superfamily |
| cd00200 | 226-378 | WD40 |
| COG5170 | 7-442 | CDC55 |
| COG2319 | 29-377 | WD40 |
| COG2319 | 170-442 | WD40 |
| COG2319 | 29-438 | WD40 |
Ontology Information
| HPRD ID | 4560 |
|---|---|
| Molecular Class | Serine/threonine phosphatase |
| Molecular Function | G-protein coupled receptor activity (GO:0004930) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.