Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| PPP3CA | 5530 | Protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform | 4 | CALN; CCN1; CNA1; CALNA; PPP2B; CALNA1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 17848589 | 2007 | Cell line : - Source : Tumor Bank Network established at the Centro Nacional de Investigaciones Oncologicas (CNIO). Sample Type : CRC tumor and normal tissue No. of Sample : 15 Stage : Duke stage A-C | Antibody Microarrays,Protein Labeling and Microarray Assay,Tissue Microarray Design and Immunohistochemistry | Up-regulation | 1.66 | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Serine/threonine phosphatases / Protein phosphatase, catalytic subunits |
| Description | - | Chromosome | 4 |
| Location | 4q24 |
| Start | 101023430 |
| End | 101347471 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 324042 |
| OMIM ID | 114105 |
| HGNC ID | HGNC:9314 |
| Unigene ID | Hs.435512 |
| Ensembl ID | ENSG00000138814 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_001130692.1 |
|---|---|
| Exon | join(1..733,151356..151556,238394..238518,247750..247861, 248960..249105,253557..253696,264209..264286, 266846..266940,286311..286385,306906..306990, 315108..315205,321411..324042) | mRNA Sequence | Download Select all |
| Length | 4520 |
CDS Information
| Location | join(676..733,151356..151556,238394..238518, 247750..247861,248960..249105,253557..253696, 264209..264286,266846..266940,286311..286385, 306906..306990,315108..315205,321411..321607) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS47113.1 |
Protein Information
| Protein ID | NP_000935.1 |
|---|---|
| Protein Name | Protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform |
| Molecular Wt. (Da) | 58557 |
| Protein Sequence | Download Select all |
| Length | 521 |
| Uniprot ID | P46108 |
| Ensembl Protein ID | ENSP00000300574 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
| EC | 3.1.3.16 |
|---|---|
| Name | phosphoprotein phosphatase protein phosphatase-1 protein phosphatase-2A protein phosphatase-2B protein phosphatase-2C protein D phosphatase phosphospectrin phosphatase casein phosphatase Aspergillus awamori acid protein phosphatase calcineurin phosphatase 2A phosphatase 2B phosphatase II phosphatase IB phosphatase C-II polycation modulated (PCM-) phosphatase phosphopyruvate dehydrogenase phosphatase phosphatase SP branched-chain alpha-keto acid dehydrogenase phosphatase BCKDH phosphatase 3-hydroxy 3-methylglutaryl coenzymeA reductase phosphatase HMG-CoA reductase phosphatase phosphatase H-II phosphatase III phosphatase I protein phosphatase phosphatase IV |
| Class | Hydrolases; Acting on ester bonds; Phosphoric-monoester hydrolases |
| Sysname | phosphoprotein phosphohydrolase |
| Substrate | phosphoprotein [CPD:C00562]; H2O |
| Product | protein [CPD:C00017]; phosphate |
| Reaction (IUBMB) |  |
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 572 | BAD | 4409 | NP_004313.1 | in vitro | 10195903 |
| 1827 | RCAN1 | 4226 | NP_004405.3 | in vitro;in vivo | 1 086 129 512 063 240 |
| 404550 | C16orf74 | 14460 | NP_996850.1 | yeast 2-hybrid | 16189514 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Alzheimer's disease | hsa05010 |
| Amphetamine addiction | hsa05031 |
| Amyotrophic lateral sclerosis (ALS) | hsa05014 |
| Apoptosis | hsa04210 |
| Axon guidance | hsa04360 |
| B cell receptor signaling pathway | hsa04662 |
| Calcium signaling pathway | hsa04020 |
| cGMP-PKG signaling pathway | hsa04022 |
| Dopaminergic synapse | hsa04728 |
| Glucagon signaling pathway | hsa04922 |
| Glutamatergic synapse | hsa04724 |
| HTLV-I infection | hsa05166 |
| Long-term potentiation | hsa04720 |
| MAPK signaling pathway | hsa04010 |
| Natural killer cell mediated cytotoxicity | hsa04650 |
| Oocyte meiosis | hsa04114 |
| Osteoclast differentiation | hsa04380 |
| Oxytocin signaling pathway | hsa04921 |
| Renin secretion | hsa04924 |
| T cell receptor signaling pathway | hsa04660 |
| Tuberculosis | hsa05152 |
| VEGF signaling pathway | hsa04370 |
| Wnt signaling pathway | hsa04310 |
Structure Information
| PDB ID | 1AUI |
|---|---|
| Resolution | 2.1 |
| Method | X-RAY DIFFRACTION |
| Chains | A |
| Molecule | SERINE/THREONINE PHOSPHATASE 2B |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd07416 | 41-345 | MPP_PP2B |
| cl13995 | 41-345 | MPP_superfamily superfamily |
| cd07415 | 56-338 | MPP_PP2A_PP4_PP6 |
| cd00144 | 86-324 | MPP_PPP_family |
| cd07417 | 43-340 | MPP_PP5_C |
| cd07414 | 52-329 | MPP_PP1_PPKL |
| cd07419 | 62-327 | MPP_Bsu1_C |
| cd07418 | 56-340 | MPP_PP7 |
| cd07420 | 40-329 | MPP_RdgC |
| pfam00149 | 84-217 | Metallophos |
| COG0639 | 154-312 | ApaH |
| cd07424 | 87-152 | MPP_PrpA_PrpB |
| cd00838 | 87-152 | MPP_superfamily |
| cd07422 | 89-205 | MPP_ApaH |
| cd07423 | 89-156 | MPP_Prp_like |
| PRK11439 | 85-152 | pphA |
| cd07425 | 89-204 | MPP_Shelphs |
| cd07421 | 85-152 | MPP_Rhilphs |
| smart00156 | 58-329 | PP2Ac |
| PTZ00239 | 51-338 | PTZ00239 |
| PTZ00480 | 52-329 | PTZ00480 |
| PTZ00244 | 64-328 | PTZ00244 |
| TIGR00668 | 89-205 | apaH |
| PHA02239 | 85-152 | PHA02239 |
| TIGR04075 | 67-152 | bacter_Pnkp |
| PRK00166 | 89-204 | apaH |
| PRK13625 | 87-160 | PRK13625 |
Ontology Information
| HPRD ID | 9050 |
|---|---|
| Molecular Class | Serine/threonine phosphatase |
| Molecular Function | Translation regulator activity (GO:0045182) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.