Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| PRDM16 | 63976 | PR domain containing 16 | 1 | MEL1, PFM13, KIAA1675, MGC166915 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24367615 | 2013 | Cell line : - Source : Sheffield Royal Hallamshire and the Sheffield Northern General hospitals and Sheffield Royal Hallamshire Hospital tissue bank (HTA License 12182). Sample Type : CRC tumor No. of Sample : 53 Stage : Duke Stage A-D | MSI Analysis,Sequencing and mutation analysis,aCGH profiling | Mutation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Zinc fingers, C2H2-type |
| Description | The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal PR domain. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] | Chromosome | 1 |
| Location | 1p36.23-p3 |
| Start | 2985565 |
| End | 3355185 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 369621 |
| OMIM ID | 605557 |
| HGNC ID | HGNC:14000 |
| Unigene ID | Hs.99500 |
| Ensembl ID | ENSG00000142611 |
| PharmGKB ID | PA33714 |
Protein Information
| Protein ID | NP_071397.3 |
|---|---|
| Protein Name | PR domain containing 16 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 1276 |
| Uniprot ID | Q9H0Y0 |
| Ensembl Protein ID | ENSP00000282185 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 10207 | INADL | 4434 | NP_733750.2 | in vitro | 16637659 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| smart00317 | 84-209 | SET |
| cl02566 | 84-209 | SET superfamily |
| pfam13465 | 965-989 | zf-H2C2_2 |
| cl22375 | 965-989 | zf-H2C2_2 superfamily |
| pfam00856 | 95-209 | SET |
| pfam13465 | 295-319 | zf-H2C2_2 |
| cl22375 | 295-319 | zf-H2C2_2 superfamily |
| pfam00096 | 951-973 | zf-C2H2 |
| cl23491 | 951-973 | zf-C2H2 superfamily |
| pfam00096 | 309-331 | zf-C2H2 |
| cl23491 | 309-331 | zf-C2H2 superfamily |
| pfam02892 | 943-972 | zf-BED |
| cl02703 | 943-972 | zf-BED superfamily |
| pfam13465 | 993-1017 | zf-H2C2_2 |
| cl22375 | 993-1017 | zf-H2C2_2 superfamily |
| pfam00096 | 394-416 | zf-C2H2 |
| cl23491 | 394-416 | zf-C2H2 superfamily |
| smart00355 | 951-973 | ZnF_C2H2 |
| cl18194 | 951-973 | ZnF_C2H2 superfamily |
| pfam13465 | 351-377 | zf-H2C2_2 |
| cl22375 | 351-377 | zf-H2C2_2 superfamily |
| COG5048 | 931-1083 | COG5048 |
| COG5048 | 335-492 | COG5048 |
| COG5189 | 320-413 | SFP1 |
Ontology Information
| HPRD ID | 5797 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Helicase activity (GO:0004386) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.