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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
PRDX1 5052 Peroxiredoxin 1  1PAG; PAGA; PAGB; PRX1; PRXI; MSP23; NKEFA; TDPX2; NKEF-A 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
20089989   2010Cell line : -

Source : Surgery departments of public hospitals in Dunedin and Auckland, New Zealand.

Sample Type : CRC tumor and normal tissue

No. of Sample : 48 primary colorectal tumours, 10 non-malignant colon tissues, 28 liver metastases and 10 nonmalignant liver tissues

Stage : TNM Stage I-IV

Biochemical isolation to nano-LC-MS/MS Unknown13,8-

17487416   2007Cell line : -

Source : Department of Pathology and Laboratory Medicine, Massachusetts General Hospital, Boston, MA.

Sample Type : CRC tumor and normal tissue

No. of Sample : 10

Stage : -

Significance analysis of microarrays.Up-regulation-real time RT-PCR confirmed that the expression of two genes associated with proliferation, CKS2 and PRDX1, were upregulated in primary tumour samples relative to normal colon, but were downregulated in metastases relative to primary tumours, indicating decreased proliferation of metastatic cells.

18549262   2008Cell line : -

Source : Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.

Sample Type : CRC tumor and normal tissue

No. of Sample : 3

Stage : TNM Stage IV

Heparin affinity fractionation enrichment (HAFE), 2-D PAGE, tandem mass spectrometric (MS/MS) identUp-regulation-PSB7, PRDX1, and SRP9 protein up-regulated in human colon adenocarcinomas.

22445993   2012Cell line : -

Source : VU University Medical Center, Amsterdam, The Netherlands.

Sample Type : CRC tumor and normal tissue

No. of Sample : -

Stage : -

Microarray, RT-PCRUp-regulation-


Gene Details



Chromosome: 1; NC_000001.10 (45976707..45988562, complement)

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Gene Type protein coding
Gene Family -
Description This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. Four transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jan 2011]  
Chromosome 1
Location 1p34.1
Start 45511035  
End 45522890  
Strand -  
Gene Sequence

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Length 11856  
OMIM ID 176763   
HGNC ID HGNC:9352   
Unigene ID Hs.180909    
Ensembl ID ENSG00000117450   
PharmGKB ID PA33722   

mRNA Information


mRNA ID NM_015506.2
Exon complement(<11824..>11856)  
mRNA Sequence

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Length 1237  



CDS Information


   
Location join(3848..3953,7084..7237,7896..8018,8254..8384, 11477..11562)
CDS Sequence

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CCDS ID CCDS522.1



Protein Information


      
Protein IDNP_001189360.1
Protein NamePeroxiredoxin 1
Molecular Wt. (Da)21979
Protein Sequence

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Length 199  
Uniprot IDQ92887
Ensembl Protein ID ENSP00000359478  



Post-translational Modification Information (Source : HPRD)


Residue Type site
YPhosphorylation194;-
YPhosphorylation194;-
YPhosphorylation194;-
TPhosphorylation183
TPhosphorylation183
TPhosphorylation183
KAcetylation27
KAcetylation27
KAcetylation27
KAcetylation7
KAcetylation7
KAcetylation7
KAcetylation35
KAcetylation35
KAcetylation35
KAcetylation16
KAcetylation16
KAcetylation16
KAcetylation197
KAcetylation197
KAcetylation197
CS-Nitrosylation173
CS-Nitrosylation173
CS-Nitrosylation173

Enzyme Information


   
EC1.11.1.15
Nameperoxiredoxin
thioredoxin peroxidase
tryparedoxin peroxidase
alkyl hydroperoxide reductase C22
AhpC
TrxPx
TXNPx
Prx
PRDX
ClassOxidoreductases; Acting on a peroxide as acceptor; Peroxidases
Sysnamethiol-containing-reductant:hydroperoxide oxidoreductase  
SubstrateR'-SH [CPD:C16736]; ROOH  
ProductR'-S-S-R' [CPD:C15496]; H2O [CPD:C00001]; ROH  
Reaction (IUBMB)



PPi Information


(Click to view network : Source STRING)      View   

                                                            
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
3661IRF34769NP_001562.1yeast 2-hybrid16189514   
4609MYC1818NP_002458.2in vitro;in vivo;yeast 2-hybrid12196529   
27244SESN17310NP_055269.1in vivo15105503   
83667SESN26378NP_113647.1in vivo15105503   


Pathway Information


      
Pathway Name Pathway ID
Peroxisome hsa04146


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd030158-180  PRX_Typ2cys
cl003888-180  Thioredoxin_like superfamily
cd0297111-157  PRX_family
cd030168-186  PRX_1cys
pfam005788-142  AhpC-TSA
COG12257-164  Bcp
cd030187-158  PRX_AhpE_like
cd0301711-158  PRX_BCP
pfam085347-152  Redoxin
PRK094377-142  bcp
cd030147-140  PRX_Atyp2cys
pfam10417162-197  1-cysPrx_C
cl22976162-197  1-cysPrx_C superfamily
COG20777-146  Tpx
cd0296621-142  TlpA_like_family
PRK005227-134  tpx
PRK031476-142  PRK03147
cd0297029-121  PRX_like2
PTZ002531-196  PTZ00253
COG04508-197  AhpC
PTZ001378-198  PTZ00137
PRK1500012-197  PRK15000
TIGR031378-186  AhpC
PRK131898-188  PRK13189
PRK103821-188  PRK10382
PRK131907-186  PRK13190
PRK1319133-177  PRK13191
PRK1359933-188  PRK13599


Ontology Information


   
HPRD ID448
Molecular ClassEnzyme: Peroxidase
Molecular FunctionPhosphoric diester hydrolase activity (GO:0008081)
Biological ProcessMetabolism (GO:0008152); Energy pathways (GO:0006091)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO