Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| PRDX2 | 7001 | peroxiredoxin 2 | 19 | PRP, NKEFB, TSA, PRXII, PRX2, MGC4104 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24234423 | 2014 | Cell line : LoVo Source : Shanghai cell bank at chinese academy of Science Shanghai china. And Tissue sample fromDepartment of Gasterointestinal surgery at the 1st affiliated hopital at the Chongqing medical University. Sample Type : - No. of Sample : 55 Stage : - | Western blotting,real time RT-PCR | Up-regulation | - | Prdx2 has an essential role in regulating oxidation-induced apoptosis in CRC cells. Prdx2 may have potential as a therapeutic target in CRC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein plays an antioxidant protective role in cells, and it may contribute to the antiviral activity of CD8(+) T-cells. The crystal structure of this protein has been resolved to 2.7 angstroms. This protein prevents hemolytic anemia from oxidative stress by stabilizing hemoglobin, thus making this gene a therapeutic target for patients with hemolytic anemia. This protein may have a proliferative effect and play a role in cancer development or progression. Related pseudogenes have been identified on chromosomes 5, 6, 10 and 13. [provided by RefSeq, Mar 2013] | Chromosome | 19 |
| Location | 19p13.2 |
| Start | 12907634 |
| End | 12912724 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 5091 |
| OMIM ID | 600538 |
| HGNC ID | HGNC:9353 |
| Unigene ID | Hs.432121 |
| Ensembl ID | ENSG00000167815 |
| PharmGKB ID | PA33723 |
mRNA Information
| mRNA ID | ?NM_005809.5 |
|---|---|
| Exon | join(1..171,641..752,842..995,1612..1734,1922..2052, 4745..5091) | mRNA Sequence | Download Select all |
| Length | 1052 |
Protein Information
| Protein ID | NP_005800.3 |
|---|---|
| Protein Name | peroxiredoxin 2 |
| Molecular Wt. (Da) | 47815 |
| Protein Sequence | Download Select all |
| Length | 198 |
| Uniprot ID | O95715 |
| Ensembl Protein ID | ENSP00000337065 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd03015 | 8-179 | PRX_Typ2cys |
| cl00388 | 8-179 | Thioredoxin_like superfamily |
| cd02971 | 11-156 | PRX_family |
| pfam00578 | 8-141 | AhpC-TSA |
| cd03016 | 8-197 | PRX_1cys |
| COG1225 | 7-163 | Bcp |
| cd03018 | 7-157 | PRX_AhpE_like |
| cd03017 | 10-157 | PRX_BCP |
| pfam08534 | 7-156 | Redoxin |
| cd03014 | 8-139 | PRX_Atyp2cys |
| PRK09437 | 9-141 | bcp |
| pfam10417 | 161-196 | 1-cysPrx_C |
| cl22976 | 161-196 | 1-cysPrx_C superfamily |
| COG2077 | 8-145 | Tpx |
| PRK00522 | 8-139 | tpx |
| cd02966 | 19-141 | TlpA_like_family |
| PRK03147 | 6-141 | PRK03147 |
| cd02969 | 9-161 | PRX_like1 |
| cd02970 | 30-139 | PRX_like2 |
| cd02968 | Nov-80 | SCO |
| COG0678 | 7-127 | AHP1 |
| COG0450 | 7-197 | AhpC |
| PTZ00253 | 1-195 | PTZ00253 |
| PTZ00137 | 8-196 | PTZ00137 |
| TIGR03137 | 8-188 | AhpC |
| PRK15000 | 8-197 | PRK15000 |
| PRK13189 | 7-192 | PRK13189 |
| PRK10382 | 1-188 | PRK10382 |
| PRK13190 | 7-185 | PRK13190 |
| PRK13191 | 8-187 | PRK13191 |
| PRK13599 | 32-187 | PRK13599 |
Ontology Information
| HPRD ID | 9880 |
|---|---|
| Molecular Class | Enzyme: Peroxidase |
| Molecular Function | DNA binding (GO:0003677) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.