Search results:
General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23807160 | 2013 | Cell line : DLD 1,COLO 205 Source : Japanese Cancer Research Bank (Tokyo, Japan), Kyushu University Beppu Hospital. Sample Type : CRC tumor and adjacent normal tissue No. of Sample : 173 Stage : - | real time RT-PCR,Immunoblotting,cell invasion assays,Soft agar and sphere formation assay | Down-regulation | - | PRRX1 is an indicator of metastasis and poor prognosis in CRC cases. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Homeoboxes / PRD class |
| Description | The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription co-activator, enhancing the DNA-binding activity of serum response factor, a protein required for the induction of genes by growth and differentiation factors. The protein regulates muscle creatine kinase, indicating a role in the establishment of diverse mesodermal muscle types. Alternative splicing yields two isoforms that differ in abundance and expression patterns. [provided by RefSeq, Jul 2008] | Chromosome | 1 |
| Location | 1q24.3 |
| Start | 170633313 |
| End | 170708541 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 75229 |
| OMIM ID | 167420 |
| HGNC ID | HGNC:9142 |
| Unigene ID | Hs.283416 |
| Ensembl ID | ENSG00000116132 |
| PharmGKB ID | PA33466 |
mRNA Information
| mRNA ID | ?NM_006902.4 |
|---|---|
| Exon | join(1..197,1579..1732,56999..57174,63493..63674, 73321..76692) | mRNA Sequence | Download Select all |
| Length | 4081 |
Protein Information
| Protein ID | NP_008833.1 |
|---|---|
| Protein Name | paired related homeobox 1 |
| Molecular Wt. (Da) | 38047 |
| Protein Sequence | Download Select all |
| Length | 245 |
| Uniprot ID | Q14683 |
| Ensembl Protein ID | ENSP00000323421 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00086 | 99-153 | homeodomain |
| cl00084 | 99-153 | homeodomain superfamily |
| pfam00046 | 99-151 | Homeobox |
| smart00389 | 99-150 | HOX |
| pfam03826 | 219-236 | OAR |
| cl08404 | 219-236 | OAR superfamily |
| COG5576 | 105-185 | COG5576 |
Ontology Information
| HPRD ID | 4319 |
|---|---|
| Molecular Class | Transcription regulatory protein |
| Molecular Function | RNA binding (GO:0003723) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.