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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 18221502 | 2008 | Cell line : SW480 Source : ATCC Sample Type : - No. of Sample : - Stage : - | cDNA arrays and analysis,Q-PCR,Western blotting,Proliferation assay,Cell cycle analysis,Immunofluorescence microscopy | Up-regulation | - | PSAT1 is overexpressed in colon tumors. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a member of the class-V pyridoxal-phosphate-dependent aminotransferase family. The encoded protein is a phosphoserine aminotransferase and decreased expression may be associated with schizophrenia. Mutations in this gene are also associated with phosphoserine aminotransferase deficiency. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 1, 3, and 8. [provided by RefSeq, Jul 2013] | Chromosome | 9 |
| Location | 9q21.2 |
| Start | 80911991 |
| End | 80945009 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 33019 |
| OMIM ID | 610936 |
| HGNC ID | HGNC:19129 |
| Unigene ID | Hs.494261 |
| Ensembl ID | ENSG00000135069 |
| PharmGKB ID | PA128395782 |
Protein Information
| Protein ID | NP_066977.1 |
|---|---|
| Protein Name | phosphoserine aminotransferase 1 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 370 |
| Uniprot ID | Q9NRE1 |
| Ensembl Protein ID | ENSP00000300762 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 346;- |
| Y | Phosphorylation | 300;- |
| K | Acetylation | 51 |
| K | Acetylation | 51 |
| K | Acetylation | 269 |
| K | Acetylation | 269 |
| K | Acetylation | 333 |
| K | Acetylation | 323 |
| K | Acetylation | 318 |
| K | Acetylation | 127 |
| K | Acetylation | 127 |
| S | Phosphorylation | 344 |
| S | Phosphorylation | 298 |
| S | Phosphorylation | 178 |
| S | Phosphorylation | 179 |
| S | Phosphorylation | 178 |
| S | Phosphorylation | 179 |
| S | Phosphorylation | 331 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Biosynthesis of amino acids | hsa01230 |
| Carbon metabolism | hsa01200 |
| Glycine, serine and threonine metabolism | hsa00260 |
| Metabolic pathways | hsa01100 |
| Vitamin B6 metabolism | hsa00750 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00611 | 8-366 | PSAT_like |
| cl18945 | 8-366 | AAT_I superfamily |
| TIGR01364 | 15-368 | serC_1 |
| PRK05355 | 6-364 | PRK05355 |
| PLN02452 | 2-369 | PLN02452 |
| PRK12462 | 5-364 | PRK12462 |
| TIGR01366 | 10-357 | serC_3 |
| PRK03080 | 9-299 | PRK03080 |
| TIGR01365 | 9-327 | serC_2 |
| cd06451 | 10-249 | AGAT_like |
| cd01494 | 57-213 | AAT_I |
| COG1932 | 5-368 | SerC |
| pfam00266 | 7-357 | Aminotran_5 |
| COG0075 | 1-215 | PucG |
| TIGR03301 | 10-266 | PhnW-AepZ |
| COG0520 | 132-366 | CsdA |
| PRK13771 | 96-132 | PRK13771 |
Ontology Information
| HPRD ID | 16542 |
|---|---|
| Molecular Class | Enzyme: Aminotransferase |
| Molecular Function | Peptide binding (GO:0042277) |
| Biological Process | Cell growth and/or maintenance (GO:0008151); Signal transduction (GO:0007165); DNA repair (GO:0006281) |
Drug Information
No matching records could be found.