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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
PSMA3 5684 Proteasome (prosome, macropain) subunit, alpha type, 3  14HC8; PSC3 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
20812987   2010Cell line : -

Source : Nanfang Hospital tumour tissue bank.

Sample Type : -

No. of Sample : 150 CRC patients

Stage : -

2-D Gel electrophoresis, and mass spectrometry,Western blotting analysis, ImmunohistochemistryUp-regulation-This gene differentially expressed in between normal colorectal tissue and colorectal cancer tissue experiment done by 2-D Gel eclectrophotesis.


Gene Details



Chromosome: 14; NC_000014.8 (58711523..58738727)

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Gene Type protein coding
Gene Family Proteasome (prosome, macropain) subunits
Description The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Two alternative transcripts encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]  
Chromosome 14
Location 14q23.2
Start 58244805  
End 58272009  
Strand +  
Gene Sequence

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Length 27205  
OMIM ID 176843   
HGNC ID HGNC:9532   
Unigene ID Hs.558799    
Ensembl ID ENSG00000100567   
PharmGKB ID -   

mRNA Information


mRNA ID NM_002788.3
Exon join(1..137,2946..3028,7315..7438,12941..13042, 13121..13194,16144..16216,18901..18966,22670..22716, 25614..25681,26130..26194,27047..27205)  
mRNA Sequence

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Length 1014  



CDS Information


   
Location join(117..137,2946..3028,7315..7438,12941..13042, 13121..13194,16144..16216,18901..18966,22670..22716, 25614..25681,26130..26194,27047..27091)
CDS Sequence

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CCDS ID CCDS9731.1



Protein Information


      
Protein IDNP_002779.1
Protein NameProteasome (prosome, macropain) subunit, alpha type, 3
Molecular Wt. (Da)28302
Protein Sequence

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Length 255  
Uniprot IDQ16539
Ensembl Protein ID ENSP00000229794  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation243
SPhosphorylation250
SPhosphorylation236
SPhosphorylation243
SPhosphorylation243
SAcetylation2
SAcetylation2
YPhosphorylation161;-
YPhosphorylation154;-
SPhosphorylation250;-
SPhosphorylation243;-
YPhosphorylation8
YPhosphorylation8
KAcetylation57
KAcetylation57
KAcetylation230
KAcetylation223
KAcetylation110
KAcetylation110
KAcetylation238
KAcetylation231
KAcetylation206
KAcetylation199
SPhosphorylation16
SPhosphorylation16

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                    
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
1026CDKN1A298NP_510867.1in vitro;in vivo11350925   
1410CRYAB428NP_001876.1in vitro;in vivo;yeast 2-hybrid11341940   
1958EGR1549NP_001955.1in vivo;yeast 2-hybrid12379479   
5683PSMA28907NP_002778.1yeast 2-hybrid14733938   
5685PSMA410168NP_002780.1in vitro1   522   563   614   733   930   
5688PSMA75967NP_002783.1in vitro;yeast 2-hybrid15225636   
6628SNRPB1655NP_937859.1yeast 2-hybrid16169070   
6636SNRPF4645NP_003086.1yeast 2-hybrid16169070   
7916BAT2807NP_542417.2yeast 2-hybrid14667819   
8328GFI1B5088NP_004179.3yeast 2-hybrid16713569   
8676STX119231NP_003755.2yeast 2-hybrid16169070   
9212AURKB5397NP_004208.2in vitro;yeast 2-hybrid14674694   


Pathway Information


      
Pathway Name Pathway ID
Proteasome hsa03050


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd037515-217  proteasome_alpha_type_3
cl004675-217  Ntn_hydrolase superfamily
cd019118-217  proteasome_alpha
pfam0022731-217  Proteasome
cd0190635-217  proteasome_protease_HslV
cd037567-199  proteasome_alpha_archeal
cd037528-217  proteasome_alpha_type_4
cd037558-196  proteasome_alpha_type_7
cd037547-184  proteasome_alpha_type_6
cd037538-204  proteasome_alpha_type_5
cd037508-179  proteasome_alpha_type_2
cd037498-179  proteasome_alpha_type_1
cd0190135-200  Ntn_hydrolase
cd0376436-156  proteasome_beta_archeal
TIGR0363436-156  arc_protsome_B
cd0191236-159  proteasome_beta
pfam1058430-Aug  Proteasome_A_N
cl1534930-Aug  Proteasome_A_N superfamily
smart0094830-Aug  Proteasome_A_N
COG06386-242  PRE1
PRK039966-245  PRK03996
TIGR036336-204  arc_protsome_A
PTZ002468-251  PTZ00246


Ontology Information


   
HPRD ID734
Molecular ClassUbiquitin proteasome system protein
Molecular FunctionCytokine activity (GO:0005125)
Biological ProcessImmune response (GO:0006955)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
P25788DB00188BortezomibSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO