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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| PSME3 | 10197 | proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) | 17 | Ki, PA28-gamma, REG-GAMMA, PA28G |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24113729 | 2013 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : - Stage : - | Western blotting, tissue microarray | Up-regulation | - | PA28 was involved in the early events of CRC. It contributes to the carcinogenesis and progression of CRC and may be a biomarker for the early diagnosis of CRC. The Western blotting results revealed that the PA28 ? expression was higher in the CRC tissue than in the healthy colorectum. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Proteasome (prosome, macropain) subunits |
| Description | The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the gamma subunit of the 11S regulator. Six gamma subunits combine to form a homohexameric ring. Alternate splicing results in multiple transcript variants. | Chromosome | 17 |
| Location | 17q12-q21 |
| Start | 42833142 |
| End | 42843760 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 10619 |
| OMIM ID | 605129 |
| HGNC ID | HGNC:9570 |
| Unigene ID | Hs.152978 |
| Ensembl ID | ENSG00000131467 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_001267045.1 |
|---|---|
| Exon | join(1..532,635..798,953..1115,1203..1235,1374..1436, 1631..1735,4508..4556,4952..5064,5590..5658,5804..5871, 5971..6025,6153..6239,8357..10619) | mRNA Sequence | Download Select all |
| Length | 3782 |
CDS Information
| Location | join(491..532,1203..1235,1374..1436,1631..1735,4508..4556, 4952..5064,5551..5658,5804..5871,5971..6025,6153..6239, 8357..8437) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS11442.1 |
Protein Information
| Protein ID | NP_001253974.1 |
|---|---|
| Protein Name | proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) |
| Molecular Wt. (Da) | 30759 |
| Protein Sequence | Download Select all |
| Length | 265 |
| Uniprot ID | Q15306 |
| Ensembl Protein ID | ENSP00000370343 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| D | Proteolytic Cleavage | 80 |
| D | Proteolytic Cleavage | 80 |
| D | Proteolytic Cleavage | 80 |
| D | Proteolytic Cleavage | 80 |
| D | Proteolytic Cleavage | 80 |
| D | Proteolytic Cleavage | 80 |
| S | Phosphorylation | 24 |
| S | Phosphorylation | 24 |
| K | Acetylation | 195 |
| K | Acetylation | 208 |
| T | Phosphorylation | 23 |
| T | Phosphorylation | 23 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 583 | BBS2 | 5855 | NP_114091.3 | yeast 2-hybrid | 16189514 |
| 4193 | MDM2 | 1272 | NP_002383.2 | in vitro | 18309296 |
| 7157 | TP53 | 1859 | NP_000537.3 | in vitro | 18309296 |
| 9513 | FXR2 | 5629 | NP_004851.2 | yeast 2-hybrid | 16189514 |
| 11033 | ADAP1 | 9733 | NP_006860.1 | yeast 2-hybrid | 16169070 |
| 54819 | ZCCHC10 | 15699 | NP_060135.1 | yeast 2-hybrid | 16189514 |
| 79446 | WDR25 | 14649 | NP_078791.3 | yeast 2-hybrid | 16189514 |
| 79873 | NUDT18 | 7992 | NP_079091.3 | yeast 2-hybrid | 16189514 |
| 284058 | KIAA1267 | 11254 | NP_056258.1 | yeast 2-hybrid | 16189514 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Antigen processing and presentation | hsa04612 |
| Hepatitis C | hsa05160 |
| Proteasome | hsa03050 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam02252 | 105-254 | PA28_beta |
| cl03502 | 105-254 | PA28_beta superfamily |
| pfam02251 | Jul-70 | PA28_alpha |
| cl03501 | Jul-70 | PA28_alpha superfamily |
Ontology Information
| HPRD ID | 1892 |
|---|---|
| Molecular Class | Ubiquitin proteasome system protein |
| Molecular Function | Receptor activity (GO:0004872) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.