Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| PTGER2 | 5732 | prostaglandin E receptor 2 (subtype EP2), 53kDa | 14 | EP2 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 17290397 | 2007 | Cell line : - Source : Uppsala Falun region of Sweden Sample Type : CRC Tumor and adjecent normal tissue. No. of Sample : 99 Stage : Dukes stage A-D | real time RT-PCR,immunohistochemistry | Up-regulation | - | EP(1) and EP(2) subtype receptor protein was highly present in tumor cells, EP(3) occurred occasionally and EP(4) was not visible |
| 18648368 | 2008 | Cell line : HT29,SW480, Caco 2 Source : - Sample Type : - No. of Sample : - Stage : - | RNA interference,Western blotting,real time RT-PCR,Immunofluorescent, immunohistochemistry | Up-regulation | - | - |
| 19055708 | 2008 | Cell line : Caco 2 Source : - Sample Type : - No. of Sample : - Stage : - | PGE2 and EP2 agonist treatments,Transepithelial Electrical Resistance (TER), Immunofluorescence Microscopy,Transmission electron microscopy. | Up-regulation | - | Central role of Prostaglandin E2-EP1 and EP2 receptor signaling to mediate AJC disassembly through a mechanism that involves PKC and claudin-1 as important target for the TJ-related effects in human colorectal cancer cells (Caco-2). |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | GPCR / Class A : Prostanoid receptors |
| Description | This gene encodes a receptor for prostaglandin E2, a metabolite of arachidonic acid which has different biologic activities in a wide range of tissues. Mutations in this gene are associated with aspirin-induced susceptibility to asthma. [provided by RefSeq, Oct 2009 | Chromosome | 14 |
| Location | 14q22 |
| Start | 52781016 |
| End | 52795324 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 14309 |
| OMIM ID | 176804 |
| HGNC ID | HGNC:9594 |
| Unigene ID | Hs.2090 |
| Ensembl ID | ENSG00000125384 |
| PharmGKB ID | PA287 |
mRNA Information
| mRNA ID | ?NM_000956.3 |
|---|---|
| Exon | join(1..1094,12924..14309) | mRNA Sequence | Download Select all |
| Length | 2494 |
Protein Information
| Protein ID | NP_000947.2 |
|---|---|
| Protein Name | prostaglandin E receptor 2 (subtype EP2), 53kDa |
| Molecular Wt. (Da) | 40371 |
| Protein Sequence | Download Select all |
| Length | 358 |
| Uniprot ID | P13164 |
| Ensembl Protein ID | ENSP00000330825 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 5730 | PTGDS | 8904 | NP_000945.3 | in vivo | 8163486 |
| 9536 | PTGES | 5528 | NP_004869.1 | in vivo | 8163486 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| cAMP signaling pathway | hsa04024 |
| Inflammatory mediator regulation of TRP channels | hsa04750 |
| Neuroactive ligand-receptor interaction | hsa04080 |
| Pathways in cancer | hsa05200 |
| Renin secretion | hsa04924 |
Structure Information
No matching records could be found.
Ontology Information
| HPRD ID | 4273 |
|---|---|
| Molecular Class | G protein coupled receptor |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P43116 | DB00770 | Alprostadil | SmallMoleculeDrug |
| P43116 | DB00917 | Dinoprostone | SmallMoleculeDrug |
| P43116 | DB00929 | Misoprostol | SmallMoleculeDrug |