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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| PTGER3 | 5733 | prostaglandin E receptor 3 (subtype EP3) | 1 | EP3 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 17290397 | 2007 | Cell line : - Source : Uppsala Falun region of Sweden Sample Type : CRC Tumor and adjecent normal tissue. No. of Sample : 99 Stage : Dukes stage A-D | real time RT-PCR,immunohistochemistry | Down-regulation | - | EP(1) and EP(2) subtype receptor protein was highly present in tumor cells, EP(3) occurred occasionally and EP(4) was not visible |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | GPCR / Class A : Prostanoid receptors |
| Description | The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor may have many biological functions, which involve digestion, nervous system, kidney reabsorption, and uterine contraction activities. Studies of the mouse counterpart suggest that this receptor may also mediate adrenocorticotropic hormone response as well as fever generation in response to exogenous and endogenous stimuli. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009] | Chromosome | 1 |
| Location | 1p31.2 |
| Start | 71318036 |
| End | 71513497 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 195462 |
| OMIM ID | 176806 |
| HGNC ID | HGNC:9595 |
| Unigene ID | Hs.445000 |
| Ensembl ID | ENSG00000050628 |
| PharmGKB ID | PA288 |
mRNA Information
| mRNA ID | ?NM_001126044.1 |
|---|---|
| Exon | join(7..1134,35331..35510,194956..195462) | mRNA Sequence | Download Select all |
| Length | 1817 |
Protein Information
| Protein ID | NP_001119516.1 |
|---|---|
| Protein Name | prostaglandin E receptor 3 (subtype EP3) |
| Molecular Wt. (Da) | 34117 |
| Protein Sequence | Download Select all |
| Length | 390 |
| Uniprot ID | O60861 |
| Ensembl Protein ID | ENSP00000322608 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 5731 | PTGER1 | 8903 | NP_000946.2 | in vitro | 11235015 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Calcium signaling pathway | hsa04020 |
| cAMP signaling pathway | hsa04024 |
| Neuroactive ligand-receptor interaction | hsa04080 |
| Pathways in cancer | hsa05200 |
| Regulation of lipolysis in adipocytes | hsa04923 |
Structure Information
No matching records could be found.
Ontology Information
| HPRD ID | 4510 |
|---|---|
| Molecular Class | G protein coupled receptor |
| Molecular Function | Transcription cofactor activity (GO:0003712) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P43115 | DB00905 | Bimatoprost | SmallMoleculeDrug |
| P43115 | DB00917 | Dinoprostone | SmallMoleculeDrug |
| P43115 | DB00929 | Misoprostol | SmallMoleculeDrug |