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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| PTGER4 | 5734 | prostaglandin E receptor 4 (subtype EP4) | 5 | EP4 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 17290397 | 2007 | Cell line : - Source : Uppsala Falun region of Sweden Sample Type : CRC Tumor and adjecent normal tissue. No. of Sample : 100 Stage : Dukes stage A-D | real time RT-PCR,immunohistochemistry | Down-regulation | - | EP(1) and EP(2) subtype receptor protein was highly present in tumor cells, EP(3) occurred occasionally and EP(4) was not visible |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | GPCR / Class A : Prostanoid receptors |
| Description | The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses. [provided by RefSeq, Jul 2008] | Chromosome | 5 |
| Location | 5p13.1 |
| Start | 40680032 |
| End | 40696962 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 16931 |
| OMIM ID | 601586 |
| HGNC ID | HGNC:9596 |
| Unigene ID | Hs.199248 |
| Ensembl ID | ENSG00000171522 |
| PharmGKB ID | PA289 |
mRNA Information
| mRNA ID | ?NM_000958.2 |
|---|---|
| Exon | join(1..981,1454..2363,17155..17266,60987..62267) | mRNA Sequence | Download Select all |
| Length | 3284 |
Protein Information
| Protein ID | NP_000949.1 |
|---|---|
| Protein Name | prostaglandin E receptor 4 (subtype EP4) |
| Molecular Wt. (Da) | 54473 |
| Protein Sequence | Download Select all |
| Length | 488 |
| Uniprot ID | O75363 |
| Ensembl Protein ID | ENSP00000379290 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Inflammatory mediator regulation of TRP channels | hsa04750 |
| Neuroactive ligand-receptor interaction | hsa04080 |
| Pathways in cancer | hsa05200 |
| Renin secretion | hsa04924 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam10328 | 29-216 | 7TM_GPCR_Srx |
| cl21561 | 29-216 | 7tm_4 superfamily |
| pfam00001 | 40-329 | 7tm_1 |
| PHA03087 | 21-127 | PHA03087 |
| PHA02638 | 26-154 | PHA02638 |
Ontology Information
| HPRD ID | 5979 |
|---|---|
| Molecular Class | G protein coupled receptor |
| Molecular Function | G-protein coupled receptor activity (GO:0004930) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P35408 | DB00917 | Dinoprostone | SmallMoleculeDrug |
| P35408 | DB00929 | Misoprostol | SmallMoleculeDrug |