Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| PTGIS | 5740 | prostaglandin I2 (prostacyclin) synthase | 20 | PGIS, CYP8A1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22109564 | 2012 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 117 CRC cases with liver metastasis (M1) and 104 cases of CRC without liver metastasis Stage : TNM Stage II,III,IV | Immunohistochemistry,tissue microarray | Up-regulation | - | PTGIS combined with lymph node involvement may be used as accurate predictors of liver metastasis in colorectal cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Cytochrome P450s |
| Description | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis. [provided by RefSeq, Jul 2008] | Chromosome | 20 |
| Location | 20q13 |
| Start | 48120411 |
| End | 48184707 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 64297 |
| OMIM ID | 601699 |
| HGNC ID | HGNC:9603 |
| Unigene ID | Hs.302085 |
| Ensembl ID | ENSG00000124212 |
| PharmGKB ID | PA292 |
mRNA Information
| mRNA ID | ?NM_000961.3 |
|---|---|
| Exon | join(1..128,17982..18105,20152..20330,23723..23866, 28450..28601,43932..44113,53776..53944,54910..55091, 56992..57143,60107..64297) | mRNA Sequence | Download Select all |
| Length | 5603 |
Protein Information
| Protein ID | NP_000952.1 |
|---|---|
| Protein Name | prostaglandin I2 (prostacyclin) synthase |
| Molecular Wt. (Da) | 20063 |
| Protein Sequence | Download Select all |
| Length | 500 |
| Uniprot ID | O00625 |
| Ensembl Protein ID | ENSP00000369785 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Nitration | 430 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Arachidonic acid metabolism | hsa00590 |
| Metabolic pathways | hsa01100 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00067 | 27-494 | p450 |
| cl12078 | 27-494 | p450 superfamily |
| PLN02196 | 232-461 | PLN02196 |
| COG2124 | 30-497 | CypX |
| TIGR04538 | 316-451 | P450_cycloAA_1 |
| PLN02302 | 294-473 | PLN02302 |
| PTZ00404 | 337-451 | PTZ00404 |
| PLN02687 | 271-475 | PLN02687 |
| PLN02936 | 294-467 | PLN02936 |
| PTZ00404 | 37-80 | PTZ00404 |
Ontology Information
| HPRD ID | 16029 |
|---|---|
| Molecular Class | Enzyme: Ligase |
| Molecular Function | Transcription regulator activity (GO:0030528) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| Q16647 | DB00812 | Phenylbutazone | SmallMoleculeDrug |
| Q16647 | DB01240 | Epoprostenol | SmallMoleculeDrug |