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General Information
- Evidence
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- Enzyme
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- Domain
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20156969 | 2010 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 320 Stage : - | Western blotting,immunostaining ,tissue immunostaining | Up-regulation | - | The overexpression of PTHR1 receptors may provide a molecular basis for efficient targeting of human tumours with radiolabelled PTH analogues. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | GPCR / Class B : Parathyroid hormone receptors |
| Description | The protein encoded by this gene is a member of the G-protein coupled receptor family 2. This protein is a receptor for parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Defects in this receptor are known to be the cause of Jansen's metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), as well as enchodromatosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010] | Chromosome | 3 |
| Location | 3p22-p21.1 |
| Start | 46919236 |
| End | 46945289 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 26054 |
| OMIM ID | 168468 |
| HGNC ID | HGNC:9608 |
| Unigene ID | Hs.1019 |
| Ensembl ID | ENSG00000160801 |
| PharmGKB ID | PA33953 |
mRNA Information
| mRNA ID | ?NM_000316.2 |
|---|---|
| Exon | join(1..127,3346..3402,5796..5918,16191..16293, 17980..18153,20139..20249,20358..20476,20662..20756, 20946..21141,21587..21740,23309..23369,23698..23764, 24050..24144,24810..24951,25033..25074,25554..26083) | mRNA Sequence | Download Select all |
| Length | 2196 |
Protein Information
| Protein ID | NP_000307.1 |
|---|---|
| Protein Name | parathyroid hormone 1 receptor |
| Molecular Wt. (Da) | 119102 |
| Protein Sequence | Download Select all |
| Length | 593 |
| Uniprot ID | O75925 |
| Ensembl Protein ID | ENSP00000249636 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 408 | ARRB1 | 146 | NP_004032.2 | in vitro;in vivo;yeast 2-hybrid | 12220636 |
| 2782 | GNB1 | 766 | NP_002065.1 | in vitro | 16099817 |
| 5741 | PTH | 1345 | NP_000306.1 | in vivo | 9108031 |
| 7533 | YWHAH | 215 | NP_003396.1 | in vitro;in vivo | 12595070 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Endocrine and other factor-regulated calcium reabsorption | hsa04961 |
| Neuroactive ligand-receptor interaction | hsa04080 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00002 | 184-455 | 7tm_2 |
| cl21587 | 184-455 | 7tm_2 superfamily |
| pfam02793 | 105-173 | HRM |
| cl02422 | 105-173 | HRM superfamily |
| smart00008 | 105-179 | HormR |
Ontology Information
| HPRD ID | 4571 |
|---|---|
| Molecular Class | G protein coupled receptor |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| Q03431 | DB05829 | Preotact | BiotechDrug |
| Q03431 | DB06285 | Teriparatide | BiotechDrug |