Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| PTPN21 | 11099 | protein tyrosine phosphatase, non-receptor type 21 | 14 | PTPD1, PTPRL10 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19000305 | 2008 | Cell line : Colo94H, Colo205, HCT8, SW1116, SW403, T84 Source : Cell Line Services (CLS), Heidelberg, Germany Sample Type : - No. of Sample : - Stage : - | Candidate cMNR Sequences in PTP Genes,cMNR Instability Analysis | Frameshift Mutation | - | Frameshift mutations were identified only in 6 PTP genes, of which PTPN21 show the highest mutation frequency at all in MSI-H tumors (17%). |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Protein tyrosine phosphatases / Class I Cys-based PTPs : Non-receptor |
| Description | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain, similar to cytoskeletal- associated proteins including band 4.1, ezrin, merlin, and radixin. This PTP was shown to specially interact with BMX/ETK, a member of Tec tyrosine kinase family characterized by a multimodular structures including PH, SH3, and SH2 domains. The interaction of this PTP with BMX kinase was found to increase the activation of STAT3, but not STAT2 kinase. Studies of the similar gene in mice suggested the possible roles of this PTP in liver regeneration and spermatogenesis. [provided by RefSeq, Jul 2008] | Chromosome | 14 |
| Location | 14q31 |
| Start | 88932122 |
| End | 89021123 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 89002 |
| OMIM ID | 603271 |
| HGNC ID | HGNC:9651 |
| Unigene ID | Hs.437040 |
| Ensembl ID | - |
| PharmGKB ID | PA33994 |
Protein Information
| Protein ID | NP_008970.2 |
|---|---|
| Protein Name | protein tyrosine phosphatase, non-receptor type 21 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 1174 |
| Uniprot ID | Q9NPI1 |
| Ensembl Protein ID | ENSP00000378180 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 492 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 660 | BMX | 2111 | NP_975010.1 | in vitro;in vivo;yeast 2-hybrid | 11013262 |
| 6714 | SRC | 1819 | NP_005408.1 | in vivo | 751 978 015 143 158 |
| 7006 | TEC | 2786 | NP_003206.2 | in vivo | 11013262 |
| 8165 | AKAP1 | 3905 | NP_003479.1 | in vitro;in vivo;yeast 2-hybrid | 15143158 |
| 10749 | KIF1C | 4342 | NP_006603.2 | in vitro;in vivo;yeast 2-hybrid | 9685376 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00047 | 923-1166 | PTPc |
| cl21483 | 923-1166 | PTPc superfamily |
| cd13188 | 217-307 | FERM_C_PTPN14_PTPN21 |
| cl17171 | 217-307 | PH-like superfamily |
| cd14473 | 116-214 | FERM_B-lobe |
| cl09511 | 116-214 | FERM_B-lobe superfamily |
| smart00404 | 1056-1166 | PTPc_motif |
| smart00012 | 1056-1166 | PTPc_DSPc |
| pfam00373 | 111-220 | FERM_M |
| pfam09380 | 226-309 | FERM_C |
| pfam09379 | 27-105 | FERM_N |
| cl09630 | 27-105 | FERM_N superfamily |
| cd00836 | 218-305 | FERM_C-lobe |
| cd13184 | 217-306 | FERM_C_4_1_family |
| cd13192 | 203-305 | FERM_C_FRMD3_FRMD5 |
| cd13189 | 217-306 | FERM_C_PTPN4_PTPN3_like |
| cd13187 | 222-303 | FERM_C_PTPH13 |
| cd13194 | 217-304 | FERM_C_ERM |
| cd13186 | 218-305 | FERM_C_NBL4_NBL5 |
| cd13193 | 211-308 | FERM_C_FARP1-like |
| cd13195 | 217-305 | FERM_C_MYLIP_IDOL |
| smart00194 | 896-1166 | PTPc |
| smart00295 | 24-222 | B41 |
| pfam00102 | 921-1166 | Y_phosphatase |
| PHA02738 | 899-1171 | PHA02738 |
| COG5599 | 919-1170 | COG5599 |
| PHA02742 | 880-1169 | PHA02742 |
| PHA02747 | 894-1168 | PHA02747 |
| PHA02746 | 909-1164 | PHA02746 |
| PHA02740 | 964-1169 | PHA02740 |
| COG2453 | 1065-1170 | CDC14 |
Ontology Information
| HPRD ID | 5655 |
|---|---|
| Molecular Class | Tyrosine phosphatase |
| Molecular Function | Receptor binding (GO:0005102) |
| Biological Process | Immune response (GO:0006955) |
Drug Information
No matching records could be found.