CoReCG

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
26137091	2015	Cell line : - Source : Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology (Warsaw, Poland) Sample Type : CRC tumor and normal tissue No. of Sample : 27 cancer patients, with 15 samples of corresponding normal colonic (NC) mucosa sections, and 42 colorectal adenoma samples Stage : -	Assessment of gene expression levels	Up-regulation	>2.5 fold	-

Gene Details

NC_000001.10 (43991708..44089343)
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Gene Type	protein coding
Gene Family	Protein tyrosine phosphatases / Class I Cys-based PTPs : Transmembrane receptor-like, "Immunoglobulin superfamily / I-set domain containing", "Fibronectin type III domain containing"
Description	The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig like domains similar to that of neural-cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherents junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]
Chromosome	1
Location	1p34
Start	43991708
End	44089343
Strand	+
Gene Sequence	Download Select all
Length	97636
OMIM ID	179590
HGNC ID	HGNC:9670
Unigene ID	Hs.272062
Ensembl ID	ENSG00000142949
PharmGKB ID	PA34015

mRNA Information

mRNA ID	?NM_002840.3
Exon	join(1..63,6420..6519,15961..16040,22794..22929, 31255..31400,31563..31704,47353..47541,56573..56683, 60845..60856,66494..66763,68735..69316,69575..69711, 70220..70364,75511..75816,76483..76676,79834..79860, 81179..81296,81374..81952,82666..82763,82953..83206, 83292..83385,84003..84221,84577..84731,87146..87261, 90531..90563,91381..91478,95208..95331,95499..95674, 96393..96512,96811..96965,97051..97336,97443..97621, 97858..97984,98217..98342,98601..98755,98860..98995, 99698..101432)
mRNA Sequence	Download Select all
Length	7723

CDS Information

Location	289..6057
CDS Sequence	Download Select all
CCDS ID	CCDS489.2

Protein Information

Protein ID	NP_002831.2
Protein Name	protein tyrosine phosphatase, receptor type, F
Molecular Wt. (Da)	161873
Protein Sequence	Download Select all
Length	1907
Uniprot ID	Q9H3D4
Ensembl Protein ID	ENSP00000264731

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
Y	Phosphorylation	1861
Y	Phosphorylation	1852
S	Glycosylation	200
N	Glycosylation	966
N	Glycosylation	957
N	Glycosylation	959
N	Glycosylation	950
Y	Phosphorylation	205
T	Phosphorylation	215
Y	Phosphorylation	217
Y	Phosphorylation	224
Y	Phosphorylation	205
T	Phosphorylation	215
Y	Phosphorylation	217
Y	Phosphorylation	224

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING) View

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
1499	CTNNB1	286	NP_001895.1	in vitro;in vivo	12 095 414 924 579 500 000 000
3643	INSR	975	NP_000199.2	in vitro;in vivo	11 158 333 155 889 800 000 000
3667	IRS1	943	NP_005535.1	in vitro	10 660 596 873 268 800 000 000
3728	JUP	1414	NP_002221.1	in vitro	9245795
3932	LCK	1080	NP_005347.3	in vitro;in vivo	12496362
5786	PTPRA	1476	NP_002827.1	in vivo;yeast 2-hybrid	10777529
6498	SKIL	1319	NP_005405.2	yeast 2-hybrid	15231748
8660	IRS2	2878	NP_003740.2	in vitro	873 268 815 588 985
55660	PRPF40A	10995	NP_060362.3	yeast 2-hybrid	15231748

Pathway Information

Pathway Name	Pathway ID
Adherens junction	hsa04520
Cell adhesion molecules (CAMs)	hsa04514
Insulin resistance	hsa04931
Insulin signaling pathway	hsa04910

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
cd00047	1377-1606	PTPc
cl21483	1377-1606	PTPc superfamily
cd00047	1667-1897	PTPc
cl21483	1667-1897	PTPc superfamily
cd05738	152-226	Ig2_RPTP_IIa_LAR_like
cl11960	152-226	Ig superfamily
cd05739	246-314	Ig3_RPTP_IIa_LAR_like
cl11960	246-314	Ig superfamily
cd00063	319-408	FN3
cl21522	319-408	FN3 superfamily
cd00063	415-507	FN3
cl21522	415-507	FN3 superfamily
cd00063	919-1007	FN3
cl21522	919-1007	FN3 superfamily
cd00063	609-703	FN3
cl21522	609-703	FN3 superfamily
cd00063	821-910	FN3
cl21522	821-910	FN3 superfamily
cd00063	710-816	FN3
cl21522	710-816	FN3 superfamily
cd00063	512-601	FN3
cl21522	512-601	FN3 superfamily
cd00096	50-121	Ig
cl11960	50-121	Ig superfamily
cd00063	1016-1075	FN3
cl21522	1016-1075	FN3 superfamily
smart00012	1794-1897	PTPc_DSPc
smart00404	1794-1897	PTPc_motif
smart00404	1505-1606	PTPc_motif
smart00012	1505-1606	PTPc_DSPc
pfam00041	919-1000	fn3
pfam00041	321-401	fn3
smart00060	919-997	FN3
cd05724	141-225	Ig2_Robo
pfam00041	609-696	fn3
smart00060	319-398	FN3
smart00060	415-497	FN3
pfam00041	514-594	fn3
pfam00041	415-500	fn3
pfam00041	710-809	fn3
smart00060	609-693	FN3
smart00060	512-591	FN3
cd00096	152-215	Ig
smart00060	710-806	FN3
cd07693	135-225	Ig1_Robo
pfam00041	834-903	fn3
cd04978	151-228	Ig4_L1-NrCAM_like
cd07693	33-120	Ig1_Robo
cd04978	47-125	Ig4_L1-NrCAM_like
smart00060	821-901	FN3
cd05729	246-315	Ig2_FGFR_like
cd05731	156-228	Ig3_L1-CAM_like
cd05724	39-124	Ig2_Robo
cd05857	142-215	Ig2_FGFR
cd05728	156-225	Ig4_Contactin-2-like
cd05728	35-124	Ig4_Contactin-2-like
cd05746	156-214	Ig4_Peroxidasin
cd05745	47-124	Ig3_Peroxidasin
cd04969	47-124	Ig5_Contactin_like
cd04968	148-225	Ig3_Contactin_like
cd05745	148-216	Ig3_Peroxidasin
cd05733	156-218	Ig6_L1-CAM_like
pfam13895	135-225	Ig_2
cd05722	35-124	Ig1_Neogenin
cd05723	52-124	Ig4_Neogenin
cd05729	142-215	Ig2_FGFR_like
cd05763	50-125	Ig_1
cd05746	54-123	Ig4_Peroxidasin
cd05726	150-215	Ig4_Robo
cd05725	50-124	Ig3_Robo
cd05725	152-225	Ig3_Robo
cd00096	249-312	Ig
cd05773	44-122	Ig8_hNephrin_like
pfam13895	233-315	Ig_2
cd05749	234-314	Ig2_Tyro3_like
cd05748	160-227	Ig_Titin_like
cd05728	238-315	Ig4_Contactin-2-like
cd04968	33-124	Ig3_Contactin_like
cd05764	150-214	Ig_2
pfam13927	231-300	Ig_3
cd05763	152-225	Ig_1
cd05747	31-115	Ig5_Titin_like
cd04972	237-315	Ig_TrkABC_d4
cd05729	52-124	Ig2_FGFR_like
cd05730	53-124	Ig3_NCAM-1_like
cd05737	141-214	Ig_Myomesin_like_C
cd05743	151-220	Ig_Perlecan_D2_like
cd05867	151-227	Ig4_L1-CAM_like
cd05765	47-124	Ig_3
cd05722	156-225	Ig1_Neogenin
cd05868	47-125	Ig4_NrCAM
cd05736	50-114	Ig2_Follistatin_like
cd05730	151-214	Ig3_NCAM-1_like
cd05856	156-214	Ig2_FGFRL1-like
cd05736	152-214	Ig2_Follistatin_like
cd05732	32-124	Ig5_NCAM-1_like
cd05725	249-315	Ig3_Robo
cd05848	33-116	Ig1_Contactin-5
cd05851	148-214	Ig3_Contactin-1
pfam13927	135-211	Ig_3
cd05852	47-124	Ig5_Contactin-1
cd04969	156-215	Ig5_Contactin_like
cd05876	153-215	Ig3_L1-CAM
cd05732	152-214	Ig5_NCAM-1_like
cd05875	156-218	Ig6_hNeurofascin_like
cd05857	243-315	Ig2_FGFR
cd05733	54-114	Ig6_L1-CAM_like
cd05891	141-214	Ig_M-protein_C
cd05739	47-123	Ig3_RPTP_IIa_LAR_like
cd05726	47-124	Ig4_Robo
cd05848	154-223	Ig1_Contactin-5
cd05856	54-124	Ig2_FGFRL1-like
cd05856	246-315	Ig2_FGFRL1-like
cd05731	54-116	Ig3_L1-CAM_like
cd04977	52-115	Ig1_NCAM-1_like
cd04967	153-222	Ig1_Contactin
cd05868	153-227	Ig4_NrCAM
cd05894	160-227	Ig_C5_MyBP-C
pfam13927	32-111	Ig_3
pfam14566	1515-1565	PTPlike_phytase
cd04978	246-315	Ig4_L1-NrCAM_like
cd05750	54-122	Ig_Pro_neuregulin
cd05851	33-124	Ig3_Contactin-1
cd05743	246-310	Ig_Perlecan_D2_like
cd04969	246-315	Ig5_Contactin_like
cd05734	153-215	Ig7_DSCAM
cd05758	42-115	Ig5_KIRREL3-like
cd05893	54-124	Ig_Palladin_C
pfam00047	246-300	ig
cd04967	33-116	Ig1_Contactin
cd05866	52-126	Ig1_NCAM-2
cd05731	251-316	Ig3_L1-CAM_like
cd05743	47-116	Ig_Perlecan_D2_like
cd05870	32-114	Ig5_NCAM-2
cd05857	46-124	Ig2_FGFR
cd05723	156-219	Ig4_Neogenin
cd05849	153-223	Ig1_Contactin-1
cd05764	47-124	Ig_2
cd00127	1791-1875	DSPc
cd05870	152-214	Ig5_NCAM-2
cd05747	141-214	Ig5_Titin_like
cd05765	151-214	Ig_3
cd05869	135-214	Ig5_NCAM-1
cd05750	157-214	Ig_Pro_neuregulin
cd05858	47-125	Ig3_FGFR-2
cd05867	47-125	Ig4_L1-CAM_like
cd04976	162-213	Ig2_VEGFR
smart00060	1016-1075	FN3
pfam00041	1017-1075	fn3
cd05869	40-124	Ig5_NCAM-1
pfam00047	47-109	ig
pfam00047	151-209	ig
cd05732	241-305	Ig5_NCAM-1_like
cd00098	34-110	IgC
smart00194	1351-1606	PTPc
smart00194	1642-1897	PTPc
pfam07679	33-124	I-set
smart00408	150-214	IGc2
smart00410	238-315	IG_like
pfam00102	1375-1606	Y_phosphatase
pfam00102	1664-1897	Y_phosphatase
COG5599	1635-1906	COG5599
COG5599	1331-1606	COG5599
PHA02738	1375-1604	PHA02738
PHA02747	1662-1888	PHA02747
PHA02742	1664-1898	PHA02742
PHA02738	1664-1903	PHA02738
PHA02746	1375-1604	PHA02746
PHA02747	1366-1601	PHA02747
PHA02742	1375-1608	PHA02742
PHA02746	1662-1894	PHA02746
PHA02740	1659-1899	PHA02740
PHA02740	1343-1604	PHA02740
smart00410	39-124	IG_like
smart00409	39-124	IG
smart00409	238-315	IG
pfam07679	232-315	I-set
pfam07679	135-225	I-set
smart00410	141-225	IG_like
smart00409	141-225	IG
COG2453	1477-1605	CDC14
smart00408	46-114	IGc2
smart00408	245-305	IGc2
PHA02785	30-328	PHA02785
COG2453	1815-1905	CDC14

Ontology Information

HPRD ID	4911
Molecular Class	Receptor tyrosine phosphatase
Molecular Function	Catalytic activity (GO:0003824)
Biological Process	Metabolism (GO:0008152); Energy pathways (GO:0006091)

SNP Information

View SNP Geneview Report